
Circadian rhythm sleep disorders (CRSD) are a family of sleep disorders that affect the timing of sleep. They are caused by a dysfunction in one's biological clock system or a misalignment between one's endogenous oscillator and externally imposed cues. People with CRSD may fall asleep at unconventional times during the day or experience excessive daytime sleepiness. These disorders can be temporary, caused by changes in routine, medications, time zone changes, or travel, or they can be long-term, caused by aging, genes, or a medical condition. The most common types of CRSD include advanced or delayed sleep-wake phase disorder, irregular or non-24-hour sleep-wake rhythm disorder, shift work disorder, and jet lag disorder. To diagnose a CRSD, a doctor may ask about sleep habits and suggest a sleep study and other diagnostic tests.
| Characteristics | Values |
|---|---|
| Type of disorder | Advanced or delayed sleep-wake phase disorder, irregular or non-24-hour sleep-wake rhythm disorder, shift work or jet lag disorder |
| Symptoms | Extreme daytime sleepiness, decreased alertness, problems with memory and decision-making, insomnia, tiredness, and the tendency to fall asleep at unwanted times |
| Causes | Aging, genes, medical condition, changes in routine, medications, time zone changes, blue light exposure, shift work, jet lag |
| Diagnosis | Sleep study, other diagnostic tests, sleep history assessment, questionnaires (MEQ, MCTQ, PSQI, ISI, Tayside children's sleep questionnaire) |
| Treatment | External stimulus therapy, bright light therapy, chronotherapy |
| Prevalence | 3% of the adult population, 10% of adults diagnosed with sleep disorders, 16% of adolescents with sleep disorders |
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What You'll Learn
- Causes: genes, aging, medical conditions, travel, work, and light exposure
- Symptoms: extreme sleepiness, low alertness, poor memory, and decision-making
- Diagnosis: a doctor may ask about sleep habits, sleep studies, and other tests
- Treatment: improving sleep habits, external stimulus therapy, and chronotherapy
- Types: advanced/delayed sleep-wake phase, non-24-hour sleep-wake rhythm, shift work, and jet lag disorder

Causes: genes, aging, medical conditions, travel, work, and light exposure
Circadian rhythm sleep-wake disorders are conditions that disrupt or affect your body's natural sleep-wake cycle. These disruptions affect how well you sleep, when you sleep, and how you function while awake. While most circadian rhythm disorders are rare, affecting about 3% of people worldwide, there are two key exceptions: jet lag and shift work sleep disorder.
Genes
You can inherit certain sleep traits and characteristics from one or both parents. Research also links certain genetic mutations to a higher risk of some circadian rhythm disorders.
Aging
Age is another factor that can contribute to circadian rhythm sleep-wake disorders. Children and teens are more likely to develop delayed sleep-wake phase disorder, while older adults, especially those over 60, are more likely to have advanced sleep-wake phase disorder.
Medical conditions
Circadian rhythm sleep-wake disorders can also be caused by medical conditions such as degenerative brain diseases, head injuries, and infections that cause encephalitis. Additionally, people with dementia or other degenerative brain diseases may experience irregular sleep-wake rhythm disorder, where sleep and wake times occur at unpredictable and disorganized intervals.
Travel
Jet lag is a common circadian rhythm disorder that occurs when traveling across multiple time zones. Traveling east, which advances your sleep cycle, tends to cause more severe jet lag than traveling west.
Work
Shift work sleep disorder (SWSD) affects those who have trouble adjusting their circadian rhythm to their work schedule, particularly those working night shifts.
Light exposure
The availability of artificial light has substantially changed the light environment, especially during the evening and night hours. This may increase the risk of developing circadian rhythm sleep-wake disorders (CRSWD), which are often caused by a misalignment of endogenous circadian rhythms and external light-dark cycles. Bright light in the morning can help you wake up, while dim light in the evening can aid in winding down.
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Symptoms: extreme sleepiness, low alertness, poor memory, and decision-making
Circadian rhythm sleep-wake disorders are conditions that disrupt or affect your body's natural sleep-wake cycle. This disruption can affect your sleep quality, sleep timing, and alertness levels during the day.
If you are experiencing symptoms such as extreme sleepiness, low alertness, poor memory, and difficulties with decision-making, it is possible that you are suffering from a circadian rhythm sleep-wake disorder. These symptoms can indicate a misalignment between your body's internal clock and the external cues that regulate sleep and wakefulness.
Extreme sleepiness during the day and decreased alertness are common symptoms of circadian rhythm disorders. This may manifest as a tendency to fall asleep at inappropriate times, such as while driving or operating machinery, which can be dangerous. You may also find it challenging to stay awake during the day, impacting your ability to function optimally at work, school, or social activities.
Low alertness and excessive daytime sleepiness can be accompanied by other cognitive impairments, including memory problems and impaired decision-making abilities. You may find yourself becoming more forgetful or struggling to concentrate and make decisions as effectively as you normally would.
If you are concerned that you may have a circadian rhythm sleep-wake disorder, it is important to consult a healthcare professional. They can evaluate your symptoms, sleep habits, and medical history to determine the underlying cause of your sleep issues and provide appropriate treatment options.
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Diagnosis: a doctor may ask about sleep habits, sleep studies, and other tests
If you suspect you may have a circadian rhythm sleep-wake disorder, it is important to consult a healthcare provider for a diagnosis. A doctor will typically begin by asking about your symptoms, taking a medical history, and performing a physical exam. They will inquire about your sleep habits, sleep patterns, and any changes in your daily routines.
During the consultation, be prepared to discuss your symptoms in detail, including when they started and how long they have been persisting. It is important to note that for a circadian rhythm disorder diagnosis, symptoms must be present for at least three months, except in the case of jet lag disorder. Your doctor will also want to know about your personal and family history of health conditions, as well as your lifestyle habits, such as caffeine, nicotine, alcohol, or drug use, and exposure to artificial light at night.
One of the key tools in diagnosing circadian rhythm sleep-wake disorders is a sleep study. This usually involves monitoring your sleep in a specialised sleep lab. During the sleep study, healthcare providers will measure various aspects of your sleep, including your sleep-wake cycles, how well you sleep, your levels of oxygen during sleep, whether and how often you stop breathing, and how much you snore. This information helps the doctor understand your sleep patterns and identify any disruptions or abnormalities.
In addition to sleep studies, doctors may recommend other diagnostic tests. One such test is actigraphy, which involves wearing a small motion sensor for 3 to 14 days to objectively measure your sleep-wake cycles. Additionally, your doctor may suggest repeated measurements of your body temperature, melatonin levels, and cortisol levels in your blood or saliva. These biomarkers can provide valuable insights into your circadian rhythm and help determine the type of circadian rhythm disorder you may have.
Remember, if you are experiencing disruptions in your sleep-wake cycle that are interfering with your daily activities, seeking professional help is essential. Your healthcare provider will guide you through the diagnosis process and recommend appropriate treatments or lifestyle changes to improve your sleep hygiene and overall well-being.
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Treatment: improving sleep habits, external stimulus therapy, and chronotherapy
Circadian rhythm sleep-wake disorders can be challenging to manage, but there are effective treatments that can help improve your sleep patterns and overall well-being. Here are some detailed strategies to address this condition:
Improving Sleep Habits:
Maintaining a consistent sleep schedule is crucial for regulating your body's internal clock. Go to bed and wake up at the same time every day, even on weekends or during vacations. This consistency helps to reinforce a stable sleep-wake cycle. Create a relaxing bedtime routine that prepares your mind and body for sleep. Engage in calming activities such as reading, listening to soothing music, or practicing relaxation techniques like deep breathing or meditation. Avoid stimulating activities and stressful conversations before bedtime. Limit your exposure to bright light in the evenings, as it can delay the release of melatonin, a hormone that promotes sleepiness. Dim your lights, avoid electronic screens for at least an hour before bed, and consider using blue light filters or installing apps that adjust the color temperature of your devices to reduce blue light exposure.
External Stimulus Therapy:
Light therapy can be an effective way to reset your body's internal clock. Expose yourself to bright light, preferably natural sunlight, soon after waking up in the morning. Sit near a window or, even better, go for a morning walk. If natural light is limited, consider investing in a light therapy box, which emits artificial bright light. Consult a healthcare professional for advice on the appropriate intensity and duration of light therapy for your specific needs. In addition to light therapy, you can use other external stimuli to promote alertness during the day and sleepiness at night. For example, engaging in regular exercise during the day can help improve your sleep quality at night. However, avoid vigorous exercise close to bedtime, as it may make it harder to fall asleep.
Chronotherapy:
Chronotherapy involves gradually shifting your sleep-wake cycle to align with your desired schedule. This is particularly useful for those with delayed sleep phase disorder, where their sleep schedule is significantly delayed compared to the typical night-time sleep pattern. To use chronotherapy effectively, you would gradually delay your bedtime and wake-up time by a small amount each day, typically by 15 to 30 minutes. This gradual shift allows your body to adjust to the new sleep schedule without causing extreme disruptions. For example, if you normally go to bed at 3 am and want to shift to a 10 pm bedtime, you would delay your bedtime by about 30 minutes each day until you reach the desired bedtime. It's important to maintain this new schedule consistently once you've reached your goal.
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Types: advanced/delayed sleep-wake phase, non-24-hour sleep-wake rhythm, shift work, and jet lag disorder
Circadian rhythm disorders, or sleep-wake cycle disorders, occur when your body's internal clock is out of sync with your environment. This internal clock, or circadian clock, cycles about every 24 hours, and your body tries to align your sleep-wake cycle with cues from the environment, such as light, meal times, and physical activity.
There are several types of circadian rhythm sleep-wake disorders, including advanced/delayed sleep-wake phase disorder, non-24-hour sleep-wake rhythm disorder, shift work sleep disorder, and jet lag disorder.
Advanced/Delayed Sleep-Wake Phase Disorder
Advanced/Delayed Sleep-Wake Phase Disorder, also known as Delayed Sleep Phase Syndrome (DSPS), is a shift in your biological clock that makes it difficult to fall asleep and wake up at normal times. People with DSPS may experience severe daytime sleepiness and changes to their mood and behaviour. Typically, they fall asleep well after midnight and have trouble waking up in time. They may describe themselves as "night owls", but unlike true night owls, they experience severe daytime dysfunction. To diagnose DSPS, a healthcare provider will ask about symptoms and may recommend a sleep diary or sleep log to be kept for several days or weeks. Treatment options include light therapy and chronotherapy, which involves gradually adjusting bedtime and wake-up times.
Non-24-Hour Sleep-Wake Rhythm Disorder
Non-24-Hour Sleep-Wake Rhythm Disorder (N24) is a condition in which an individual's biological clock fails to synchronize with a 24-hour day. Their sleep time gradually delays by minutes to hours every day, resulting in a cycle that goes all the way around the clock. N24 is common in blind people but also occurs in sighted individuals. This disorder can lead to severe and cumulative sleep deprivation as individuals struggle to adhere to a typical sleep schedule.
Shift Work Sleep Disorder
Shift Work Sleep Disorder (SWSD) affects people whose work hours overlap with their typical sleep period. It is characterized by insomnia, excessive sleepiness, or both. SWSD is often undiagnosed, but it is estimated that 10-40% of shift workers experience it. This disorder can lead to decreased bone mineral density, an increased risk of fractures, low fertility, and a higher prevalence of certain health issues such as obesity, diabetes, and mental disorders.
Jet Lag Disorder
Jet lag is a circadian rhythm disorder that occurs when an individual's internal clock is out of sync with the time zone they are in. It is commonly experienced by those who frequently travel long distances, such as pilots and flight attendants. Jet lag can cause fatigue, insomnia, irritability, and digestive problems. The circadian clock typically takes 1-1.5 days to adjust per time zone crossed, and light is the most effective environmental cue to help reset the clock.
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Frequently asked questions
Circadian rhythm sleep-wake disorders (CRSWD) are a family of sleep disorders that affect the timing of sleep. If you have a CRSWD, you may experience a persistent pattern of sleep/wake disturbances that arise from a dysfunction in your biological clock system or a misalignment between your endogenous oscillator and externally imposed cues. This could manifest as falling asleep at unconventional times or excessive daytime sleepiness. To be diagnosed with a circadian rhythm sleep disorder (CRSD), you must have a misalignment between the timing of your circadian oscillator and the surrounding environment or a failure in your clock entrainment pathway. A sleep specialist will gather your sleep and wake habits, body temperature patterns, and dim-light melatonin onset (DLMO) to assess your current schedule and the physiological phase markers of your biological clock.
The four main types of CRSD are delayed sleep phase disorder, advanced sleep phase disorder, non-24-hour sleep-wake disorder, and irregular sleep-wake rhythm disorder. The type of disorder you have depends on your pattern of sleep and wakefulness. Advanced sleep phase disorder involves evening sleepiness, early sleep onset, and waking up earlier than desired. Delayed sleep phase disorder involves falling asleep later than desired and difficulty waking up on time in the morning. Non-24-hour sleep-wake rhythm disorder occurs when your circadian rhythm extends slightly beyond the regular 24-hour schedule, causing your sleep and wake times to gradually shift later each day. Irregular sleep-wake rhythm disorder can be caused by changes in routine, medications, and time zone changes.
Treatment for circadian rhythm sleep-wake disorders aims to adjust the patient's sleep pattern so they can get the necessary sleep and function daily. This includes external stimulus therapies such as bright light therapy or chronotherapy, a behavioral technique in which bedtime is gradually adjusted to achieve the desired bedtime. Bright light therapy is designed to reset a patient's circadian rhythm to a desired pattern.



































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