
Sleep-wake disorders are conditions that affect the quality and duration of sleep and wakefulness. There are over 80 different sleep disorders, with insomnia being the most common. Sleep-wake disorders can be caused by a variety of biological factors, including medical conditions, psychiatric conditions, and physical abnormalities. For example, cardiac conditions such as ischemia and congestive heart failure can disrupt sleep, as can neurological conditions such as stroke, degenerative conditions, and dementia. Psychiatric conditions such as depression, anxiety, and post-traumatic stress disorder (PTSD) are also associated with sleep-wake disorders. Additionally, biological factors such as age, lifestyle, and health can contribute to sleep problems. Sleep-wake disorders can have significant impacts on daytime functioning, including fatigue, decreased energy, and irritability.
| Characteristics | Values |
|---|---|
| Number of sleep-wake disorders | Over 80 |
| Most common sleep-wake disorders | Insomnia, sleep apnea, parasomnias, narcolepsy, restless leg syndrome |
| Age | Sleep disorders can occur at any age but most commonly start in young adulthood |
| Prevalence | More than 50 million Americans have chronic sleep disorders |
| Circadian rhythm sleep-wake disorders | The body's internal clock is misaligned with the external light-darkness cycle |
| Prevalence of delayed sleep phase type | Estimated between 0.2% and 1.7% of adults, but may be as high as 4.6% in adolescents |
| Prevalence of advanced sleep phase type | Approximately 1% in middle-aged adults and more common in older adults |
| Causes of circadian rhythm disorders | Internal factors (body clock different from light-dark cycle), external factors (shift work, jet lag), brain damage, vision impairments, unknown reasons |
| Symptoms of sleep disorders | Difficulty falling asleep, trouble staying asleep, snoring, gasping or choking during sleep, feeling tired during the day, behavioural and mood changes |
| Diagnosis | Medical history, sleep history, physical exam, sleep study, sleep diary, clinical testing |
| Treatment | Good sleep habits, lifestyle changes, cognitive behavioural therapy, CPAP machine, medications |
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What You'll Learn

Circadian rhythm sleep-wake disorders
There are several types of circadian rhythm sleep-wake disorders. Advanced sleep-wake phase disorder (ASWPD) involves individuals finding it very difficult to stay awake in the early evening and, as a result, waking up too early in the morning. This can interfere with work, school, or social responsibilities. Delayed sleep-wake phase disorder (DSWPD) involves individuals falling asleep later than they would like and then finding it difficult to wake up on time in the morning. This can also interfere with daily life.
Another type of circadian rhythm sleep-wake disorder is non-24-hour sleep-wake rhythm disorder (N24SWD), where an individual's circadian rhythm extends slightly beyond the regular 24-hour schedule. This results in bedtimes and wake-up times shifting a little later each day. In some cases, an individual with N24SWD may appear to have a normal sleep schedule, but at other times, they may get most of their sleep during the daytime. N24SWD typically occurs when an individual's circadian rhythm is not properly regulated by external factors, such as light exposure.
Shift work disorder is another type of circadian rhythm sleep-wake disorder that affects those who work during the night or on rotating schedules. As a result of their work schedule, individuals with this disorder may not be able to get uninterrupted quality sleep when their body needs it. They may experience insomnia, extreme tiredness, and sleepiness while working at night. It is estimated that at least one-third of shift workers have this disorder, which can increase their risk of accidents.
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Insomnia
Sleep-wake disorders, or sleep disorders, involve problems with the quality, timing, and amount of sleep, which result in daytime distress and impairment in functioning. Insomnia is the most common sleep disorder, affecting around a third of adults, and is characterised by chronic dissatisfaction with sleep quantity or quality, difficulty falling asleep, and frequent nighttime awakenings.
There are several biological factors that can contribute to insomnia. One of the most significant factors is hyperarousal, which is characterised by heightened physiologic, affective, or cognitive activity that interferes with the natural "disengagement from the environment" and makes it difficult to fall asleep. Hyperarousal can be detected by increased cortisol, heart rate variability, EEG, or self-report. It is important to note that the exact threshold for categorising hyperarousal is not well defined, and studies often identify it by comparing differences between insomnia and control groups.
Genetics also play a role in insomnia. Genome-wide association analyses have identified 57 loci associated with insomnia symptoms, providing evidence of shared genetic architecture between insomnia and other traits such as cardiometabolic, behavioural, psychiatric, and reproductive traits. Additionally, genes linked to brain functioning, arousal regulation, and sleep-wake processes have been consistently found to be associated with insomnia. The complex interplay of these genes may contribute to the variation in insomnia symptoms and consequences. Further genetic studies are needed to refine our understanding of the genetic factors involved in the development and characteristics of insomnia.
Ageing is another biological factor that can contribute to insomnia. As people age, they tend to get less sleep and spend less time in the deep, restful stage of sleep. Older adults are more easily awakened and are more likely to experience sleep disruptions due to medical conditions or medications. Sleep problems can also be a side effect of certain medications or substances, and in some cases, insomnia may persist even after the underlying condition has been treated or resolved.
To diagnose insomnia, a physician will rule out other sleep disorders, medication side effects, substance misuse, depression, and other physical and mental illnesses. A comprehensive assessment may include a patient history, a physical exam, a sleep diary, and clinical testing such as a sleep study or polysomnography. Treatment for insomnia may involve lifestyle changes, cognitive behavioural therapy, relaxation techniques, and in some cases, medication.
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Sleep apnea
The symptoms of sleep apnea can affect both night and day. During sleep, individuals with sleep apnea may experience unusual breathing patterns, such as fast breathing that gradually becomes shallower until breathing stops and then starts again. They may also snore loudly, snort, gasp, or make choking sounds. Sleep apnea can cause excessive daytime sleepiness or "microsleeps", which are brief periods of sleep that can occur during the day and are dangerous when driving or operating machinery. Other potential complications include arrhythmias, high blood pressure, heart damage, and even sudden cardiac death.
To diagnose sleep apnea, a healthcare provider will assess an individual's symptoms and medical history. They may recommend specific tests, such as a sleep study, to confirm the diagnosis. While sleep apnea can be managed, it is important to seek help from a healthcare provider to ensure proper treatment and improve sleep quality.
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Parasomnias
There are three main groups of parasomnias, classified based on the stage of sleep they affect. The first group is Non-Rapid Eye Movement (non-REM) parasomnias, which occur during the first three stages of sleep, from the moment of falling asleep to about the first half of the night. Non-REM parasomnias involve physical and verbal activity, such as sleepwalking and sleep-talking. The second group is Rapid Eye Movement (REM) parasomnias, which occur during the latter part of the night, following the three non-REM stages. REM sleep is characterised by rapid eye movements under closed eyelids, increased heart rate, breathing, and blood pressure, and vivid dreaming. The third group is "Other" parasomnias, which do not fit neatly into either the non-REM or REM sleep phases.
The exact causes of parasomnias are not always clear, but researchers have identified several potential triggers. One significant factor is sleep deprivation; when individuals do not get enough sleep, they become more susceptible to experiencing parasomnias. This may be due to the alteration of sleep stages caused by sleep deprivation. Additionally, frequent nighttime sleep disruptions can provoke parasomnias, further highlighting the importance of uninterrupted sleep.
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Restless leg syndrome
The exact cause of RLS is not fully understood, but it is believed to be related to changes in the neurotransmitter dopamine and resulting anomalies in the iron system. Specifically, impaired neuronal iron uptake affects the functions of the neuromelanin-containing and dopamine-producing cells, which may lead to abnormal dopaminergic transmissions in the brain. This can cause the basal ganglia, the part of the brain responsible for movement, to be unable to regulate movement efficiently.
RLS may also be linked to iron deficiency, either due to low total body iron status or underlying conditions such as anemia caused by internal bleeding or bone marrow issues. Other associated conditions include end-stage kidney disease, folate and magnesium deficiencies, sleep apnea, diabetes, peripheral neuropathy, Parkinson's disease, and certain autoimmune diseases such as multiple sclerosis. Additionally, RLS can be worsened by the use of alcohol, nicotine, and caffeine.
While there is no cure for RLS, treatment options are available. Lifestyle modifications, such as improving sleep hygiene, regular exercise, and stopping smoking, can help reduce the frequency of symptoms. In terms of medication, dopamine agonists, gabapentinoids, and opioids in severe cases may be prescribed. If RLS is secondary to another medical condition, treating the underlying cause can be effective. For example, managing anemia or addressing elevated estrogen levels during pregnancy can improve RLS symptoms.
RLS can affect people of all ages, although it is more common in adults over 50, and symptoms tend to worsen with age. Diagnosis of RLS is based on a person's symptoms and ruling out other potential causes through a physical exam, neurological exam, blood tests, and, in some cases, an overnight sleep study.
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Frequently asked questions
Sleep-wake cycles are governed by a complex group of biological processes that serve as internal clocks. The suprachiasmatic nucleus, located in the hypothalamus, is thought to be the body's anatomic timekeeper, responsible for the release of melatonin on a 25-hour cycle. The pineal gland secretes less melatonin when exposed to bright light, which is why daylight is a key set point. The body generally runs on a sleep-wake cycle that lasts a little over 24 hours.
There are over 80 types of sleep disorders, but some of the most common include insomnia, sleep apnea, restless leg syndrome, narcolepsy, and parasomnias.
Symptoms of sleep-wake disorders vary depending on the type of disorder, but some common signs include regularly taking more than 30 minutes to fall asleep, waking up several times a night, and feeling sleepy during the day.
Sleep-wake disorders often occur alongside other medical or mental health conditions, such as depression, anxiety, cardiac conditions, or pulmonary conditions. They can also be caused by external factors such as shift work or jet lag.
Treatment for sleep-wake disorders depends on the specific disorder but may include good sleep habits, cognitive behavioural therapy, relaxation techniques, medication, or the use of a CPAP machine.




























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