
Unisom and Benadryl are both over-the-counter (OTC) sleep medications that can help people struggling with sleep disorders or occasional insomnia. They are known to induce drowsiness and promote better sleep patterns. However, they differ in their active ingredients and side effects. Unisom contains doxylamine succinate, an antihistamine that blocks histamines to cause drowsiness. Benadryl, on the other hand, contains diphenhydramine, an antihistamine with broader effects on allergy symptoms. While Benadryl may cause daytime drowsiness, Unisom is known to be non-habit forming. The choice between the two sleep aids depends on individual responses to medications and specific health needs.
| Characteristics | Values |
|---|---|
| Active Ingredients | Unisom: Doxylamine succinate; Benadryl: Diphenhydramine HCl |
| Working | Unisom: Blocks histamines; Benadryl: Blocks histamines and acetylcholine |
| Effectiveness | Unisom: Works for 30 minutes; Benadryl: Works for insomnia and allergies |
| Side Effects | Unisom: Daytime drowsiness; Benadryl: Dry mouth, blurred vision, urinary retention, dizziness, headache, constipation, sleepwalking, altered mental state |
| FDA Approval | Unisom: Approved in 1948; Benadryl: Approved in 1946 |
| Addiction | Both are unlikely to be addictive when taken as directed |
| Precautions | Unisom: Not for children under 12; Benadryl: Not for children under 12 and older people |
Explore related products
What You'll Learn
- Benadryl and Unisom are antihistamines with sedative side effects
- Benadryl contains diphenhydramine HCl, Unisom contains doxylamine succinate
- Benadryl may cause daytime drowsiness, impairing ability
- Unisom is milder, with less of a 'hangover effect'
- Antihistamines can cause sleepwalking and other parasomnias

Benadryl and Unisom are antihistamines with sedative side effects
Benadryl and Unisom are over-the-counter (OTC) sleep medications with antihistamine properties and sedative side effects. They are often recommended for their accessibility and effectiveness in promoting restful sleep. However, it's important to note that they should be used responsibly due to potential side effects and the risk of developing a tolerance or dependence.
Unisom, or doxylamine succinate, is an antihistamine that works by blocking histamines, causing drowsiness and helping users fall asleep faster. It is the number one doctor-recommended OTC sleep aid brand and is particularly effective for short-term insomnia. Unisom is considered non-habit forming and generally well-tolerated, but it should not be used by children under 12 years old.
On the other hand, Benadryl, or diphenhydramine, is also an antihistamine but with a broader range of effects. In addition to blocking histamines, it inhibits acetylcholine, promoting more effective sedation. Benadryl is also useful for treating allergies and colds due to its antihistamine properties. However, it may cause daytime drowsiness, impairing activities such as driving or operating machinery. Benadryl should not be taken by older individuals or in combination with certain medications.
While both Benadryl and Unisom can aid in sleep, they may affect individuals differently due to varying responses to medications. It is always advisable to consult a healthcare provider for personalized advice based on one's specific situation and health status. Additionally, natural alternatives, such as melatonin and valerian root, can be considered, although their effectiveness may vary.
It is worth noting that the American Academy of Sleep Medicine does not recommend antihistamines for treating insomnia, and there is limited research on the effectiveness of over-the-counter sleep aids. Insomnia is a complex condition that may have underlying medical causes, and it is important to consult a physician or specialist for long-term sleep issues.
Coffee Size: The Sleep-Deprived's Guide to Caffeine
You may want to see also
Explore related products

Benadryl contains diphenhydramine HCl, Unisom contains doxylamine succinate
Benadryl and Unisom are both over-the-counter (OTC) sleep medications that can help with insomnia. However, they contain different active ingredients. Benadryl contains diphenhydramine HCl, which is an antihistamine. Antihistamines are used to treat symptoms related to hay fever, upper respiratory allergies, or cold symptoms. They work by blocking histamine from binding to H1 receptors in the body, thereby providing relief from allergy symptoms such as a runny nose, sneezing, and itchy eyes. Diphenhydramine can be taken orally or applied topically and is often combined with other active ingredients like zinc acetate to protect the skin and relieve itching. Benadryl can cause drowsiness and should not be used by older people or in combination with alcohol, sedatives, or tranquilizers. It should also be avoided during pregnancy or breastfeeding without consulting a healthcare professional first.
On the other hand, Unisom contains doxylamine succinate, which is also an antihistamine. Doxylamine succinate helps people fall asleep faster and stay asleep all night. Unisom SleepTabs® are FDA-approved and contain 25 mg of doxylamine succinate. Unlike diphenhydramine, doxylamine succinate cannot be used in children under 12. It is also important to note that both diphenhydramine and doxylamine succinate can cause side effects and should not be overused. If you find yourself needing to take either of these medications more than three times a week, it is recommended to consult a healthcare provider for alternative treatment options.
While both Benadryl and Unisom are effective sleep aids, the choice between the two depends on individual needs and preferences. It is always advisable to speak to a healthcare professional before starting any new medication to ensure it is safe and suitable for your specific circumstances.
Space Marines: Sustenance, Sleep, and Their Superhuman Needs
You may want to see also
Explore related products

Benadryl may cause daytime drowsiness, impairing ability
Benadryl is a common over-the-counter antihistamine medication used to treat allergies and the common cold. Its active ingredient, diphenhydramine, is a first-generation H1-antihistamine that blocks histamine-1 receptors in the brain, which can lead to drowsiness. This drowsy effect can help people fall asleep, but it may also cause daytime drowsiness, impairing your ability to perform certain activities.
Benadryl may cause daytime drowsiness that can last about eight hours, and may even persist into the next day if taken at night. This can affect your ability to drive, operate machinery, or perform other hazardous activities safely. It is advised that you do not engage in these activities if you experience drowsiness or dizziness while taking Benadryl. Alcohol consumption and the use of other medications that cause sleepiness can worsen these effects, so caution is advised when consuming alcohol or combining medications with Benadryl.
The drowsiness caused by Benadryl may also be accompanied by other side effects, including dry mouth, blurred vision, dizziness, difficulty concentrating, and urinary retention. These side effects can further impair your ability to perform certain tasks, especially those requiring concentration, coordination, and clear vision. It is important to be aware of these potential impairments and adjust your activities accordingly when taking Benadryl.
While Benadryl can help with falling asleep, it may not improve overall sleep quality. Research has shown that the more someone relies on Benadryl as a sleep aid, the less effective it becomes over time. Additionally, the use of Benadryl for sleep in older adults (65 years and older) is not recommended due to an increased risk of side effects, such as dry mouth, dry eyes, and confusion, as well as an increased risk of falling.
It is important to note that Benadryl is not the only option for sleep aids. Unisom, for example, is another over-the-counter sleep medication that contains doxylamine succinate as its active ingredient. Doxylamine succinate tends to have a longer-lasting effect than diphenhydramine and is not recommended for children under 12. Other alternatives include natural sleep remedies like melatonin and valerian root, although their effectiveness may vary among individuals.
Sleep and Aging: Understanding the Connection
You may want to see also
Explore related products
$9.99

Unisom is milder, with less of a 'hangover effect'
Unisom and Benadryl are both over-the-counter (OTC) sleep medications that can help people struggling with sleep disorders or occasional insomnia. However, they differ in their active ingredients and side effects. While Benadryl can be effective in treating insomnia, it may cause daytime drowsiness, which can impair your ability to drive or operate machinery safely. This side effect gives Unisom an edge over Benadryl as a milder option with less of a "hangover effect".
Unisom's active ingredient is doxylamine succinate, an antihistamine that blocks histamines to induce drowsiness and help you fall asleep faster. On the other hand, Benadryl's active ingredient is diphenhydramine, an antihistamine with a broader effect on allergy symptoms. Both medications can effectively induce drowsiness, but Benadryl's side effects can include dry mouth, blurred vision, and urinary retention.
Unisom is generally well-tolerated and is the #1 doctor-recommended OTC sleep-aid brand. It is also non-habit forming, so you don't have to worry about dependence. Unisom helps you fall asleep up to 30 minutes faster, and you wake up feeling refreshed. The effectiveness of Unisom has been recognised by experts, which is why it is the top choice for many healthcare professionals.
While Benadryl can be effective in treating insomnia, its side effects can be more pronounced, and it may not be suitable for everyone. Benadryl can cause daytime drowsiness, which can impact your daily activities and even impair your ability to drive or operate machinery. This side effect is not as prevalent with Unisom, making it a milder option.
Additionally, Benadryl should not be taken by older people or individuals taking certain medications for anxiety or depression. It is important to consult your healthcare provider before taking Benadryl to ensure it is safe for you. Unisom, on the other hand, does not have the same age-related restrictions and can be a milder alternative for older individuals.
In summary, while both Unisom and Benadryl can be effective in treating insomnia, Unisom is generally milder and has less of a "hangover effect". Unisom is well-tolerated, non-habit forming, and recommended by doctors, making it a safer and more preferred option for many individuals struggling with sleep issues.
Napping: The Power of Split Sleep
You may want to see also
Explore related products

Antihistamines can cause sleepwalking and other parasomnias
Antihistamines are commonly used as over-the-counter sleep aids, with Benadryl and Unisom being two popular options. However, while they may help you fall asleep, they can also lead to parasomnias, including sleepwalking.
Parasomnias are a category of sleep disorders characterised by abnormal and unpleasant experiences in emotions, behaviours, and movements. Somnambulism, or sleepwalking, is one such parasomnia. It involves a range of behaviours, from unwanted movements during sleep to getting out of bed and walking around. While somnambulism is more common in children, it can also occur in adults, especially with certain medications.
Antihistamines like Benadryl and Unisom have been linked to an increased risk of somnambulism and other parasomnias. In some cases, these medications can cause sleepwalking and other abnormal behaviours during sleep. This is particularly true when antihistamines are combined with alcohol or other substances. Additionally, antihistamines can sometimes have the opposite effect, causing hyperactivity, especially in children.
The use of antihistamines as sleep aids is controversial due to their potential side effects and limited effectiveness. While they may help you fall asleep, they do not necessarily improve overall sleep quality. The American Academy of Sleep Medicine does not recommend antihistamines for treating insomnia, as there are often better alternatives available.
If you are considering using Benadryl or Unisom as a sleep aid, it is important to be aware of the potential risks and side effects. These medications can cause sleepwalking and other parasomnias, and they may not provide long-term benefits. It is always advisable to consult a healthcare professional before taking any sleep medication to ensure you are making an informed decision about your health.
Valerian vs Chamomile: Which Herb Helps You Sleep Better?
You may want to see also
Frequently asked questions
Benadryl and Unisom are over-the-counter (OTC) sleep medications that have sedative properties and can help promote restful sleep.
Benadryl and Unisom have similar side effects, including dry mouth, dizziness, headache, constipation, blurred vision, and urinary retention. Benadryl may also cause daytime drowsiness, impairing your ability to drive or operate machinery.
The choice between Benadryl and Unisom depends on individual responses to medication. Unisom is recommended for occasional sleeplessness and is non-habit forming. Benadryl may be preferred for its additional benefits in treating allergies and colds. However, it may cause daytime drowsiness. It is essential to consult a healthcare provider for advice tailored to your specific situation and health status.











































