
Lexapro (escitalopram) is an antidepressant medication used to treat depression and anxiety. While it can help some people sleep better, insomnia is a common side effect, affecting 9-12% of patients. This may be due to individual factors like age, dosage, and overall health. If you're experiencing insomnia while taking Lexapro, there are some sleep aids that are generally considered safe to take with it. However, it's important to consult your doctor or pharmacist before combining Lexapro with any other medication, including over-the-counter sleep aids, to avoid potential drug interactions and side effects.
| Characteristics | Values |
|---|---|
| Safe Sleeping Pills with Lexapro | Diphenhydramine, Doxylamine, Melatonin, Valerian Root, Zolpidem (Ambien), Eszopiclone (Lunesta), Trazodone |
| Side Effects | Dizziness, drowsiness, confusion, difficulty concentrating, impaired thinking, impaired judgment, impaired motor coordination |
| Precautions | Avoid/limit alcohol, avoid activities requiring alertness (e.g. driving), consult a doctor, avoid caffeine, exercise regularly, maintain a sleep schedule |
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What You'll Learn

Melatonin supplements
Lexapro (escitalopram) is an antidepressant that can sometimes cause insomnia as an adverse effect. This is more common in patients taking Lexapro for generalized anxiety disorder (GAD) than for major depressive disorder (MDD). Patients usually have trouble sleeping during the first week of treatment, and sleep issues can last from a few days to a few weeks.
Melatonin is a hormone that is naturally produced in the body to help regulate the sleep-wake cycle. It is available in supplement form and is often used to help people fall asleep faster and stay asleep longer. Melatonin supplements may be a good option for people taking Lexapro who are experiencing insomnia. Melatonin supplements are also generally considered safe for use with antidepressants. However, melatonin supplements are not suitable for pregnant or breastfeeding women or those with autoimmune disorders, seizure disorders, or depression. Melatonin can also raise blood sugar and blood pressure levels in people taking certain medications for hypertension. It is important to consult a doctor before taking melatonin supplements to ensure they are safe for you. The recommended dose of melatonin is 1 to 3 milligrams, or up to 5 milligrams depending on the source, taken 30 minutes to two hours before bedtime.
In addition to melatonin supplements, there are other sleep aids that can be taken with Lexapro. Some over-the-counter options include diphenhydramine, doxylamine, and valerian root. It is important to note that doxylamine can increase the side effects of Lexapro, such as dizziness, drowsiness, confusion, and difficulty concentrating. Alcohol can also increase these side effects, so it is recommended to avoid or limit alcohol consumption when taking Lexapro and doxylamine. Prescription sleep aids like zolpidem (Ambien), eszopiclone (Lunesta), and trazodone can also be used if deemed appropriate by a healthcare professional.
To improve sleep quality while taking Lexapro, it is recommended to establish a consistent sleep routine, avoid caffeine and alcohol, and limit exposure to bright lights and technology before bedtime. Regular exercise and a healthy diet can also promote better sleep.
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Valerian root supplements
Valerian root is an herb that is available in supplement form and has been used for centuries to help people relax and sleep better. Valerian root is a sedative that acts on the brain and nervous system. It is often used for sleep disorders, especially insomnia, and can be taken in the form of tea, tinctures, or dietary supplements. The recommended dosage of valerian root is 400-900 milligrams, taken 30 minutes to two hours before bedtime. It is important to consult with a doctor or healthcare provider before taking any new sleep aid, including valerian root, to ensure that it is safe and appropriate for your individual needs.
When considering the use of valerian root supplements, it is important to be aware of potential side effects and interactions. While valerian root is generally considered safe, some people may experience side effects such as drowsiness, dizziness, or impaired thinking and judgment. These side effects may be similar to those of Lexapro, so it is important to be cautious when combining the two. Additionally, valerian root can interact with other medications or supplements, so it is crucial to inform your doctor about all substances you are taking to ensure safe and effective treatment.
Overall, valerian root supplements can be a safe and effective option for improving sleep quality, especially when combined with Lexapro. However, individual results may vary, and it is always recommended to consult with a healthcare professional before taking any new supplement to ensure it is safe and appropriate for your specific needs and medical history.
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Prescription sleep aids
Lexapro (escitalopram) is an antidepressant medication used to treat depression and anxiety. A common side effect of this medication is insomnia, which is experienced by 9% of patients with major depressive disorder and 12% of those with generalized anxiety disorder. This side effect is more likely to occur during the first week of treatment and may last from a few days to a few weeks.
To mitigate insomnia while taking Lexapro, it is recommended to take the medication in the morning to give the body time to break down the drug before bedtime. Other general recommendations include avoiding caffeine and alcohol, exercising regularly, and maintaining a consistent sleep schedule.
If these measures do not help, there are some over-the-counter and prescription sleep aids that can be considered, preferably after consultation with a doctor. Over-the-counter options include diphenhydramine (found in Benadryl and Tylenol PM), doxylamine, melatonin, and valerian root. It is important to note that doxylamine can increase side effects such as dizziness and drowsiness when taken with Lexapro, so caution is advised.
- Trazodone: This medication is typically taken at a dosage of 50-100 mg at bedtime.
- Eszopiclone (Lunesta): The recommended dosage for this drug is 1-3 mg at bedtime.
- Zolpidem (Ambien): Zolpidem is usually taken at a dosage of 5-10 mg at bedtime.
These prescription sleep aids may cause side effects such as drowsiness, headaches, dizziness, and confusion. It is important to monitor these effects and report them to a healthcare professional. Additionally, combining Lexapro with prescription sleep aids may increase the risk of certain side effects, so medical advice should be sought before taking them together.
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Doxylamine and Lexapro side effects
Lexapro (escitalopram) is a prescription drug used to treat certain mental health conditions. It is not a sleep aid, but it can help individuals who struggle to sleep due to anxiety and depression. While Lexapro can improve sleep quality over time, some patients experience insomnia as a side effect, especially during the first week of treatment. This usually improves as the body adjusts to the medication, but it can take a few weeks.
Doxylamine is an antihistamine used to treat insomnia and allergy symptoms. It is available over the counter and is commonly found in sleep aids such as Unisom and ZzzQuil. The most common side effect of doxylamine is drowsiness, but it can also cause dizziness, confusion, and impaired thinking, judgment, and motor coordination, especially in the elderly. Severe allergic reactions are also possible.
When doxylamine is taken with Lexapro, these side effects may be amplified. Both drugs can cause drowsiness, dizziness, confusion, and impaired thinking, judgment, and motor coordination. Therefore, it is recommended to avoid activities requiring alertness or coordination until you know how the medications affect you. It is also advised to avoid or limit alcohol consumption while taking these medications, as it can worsen nervous system side effects.
If you are considering taking doxylamine with Lexapro, it is important to consult your doctor or pharmacist beforehand. They can advise you on potential interactions, side effects, and whether this combination is safe for you.
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Lifestyle changes to improve sleep
Lexapro (escitalopram) is a medication used to treat symptoms of major depressive disorder (MDD) and generalized anxiety disorder (GAD). However, insomnia is a common adverse effect, with 9% of patients with MDD and 12% of patients with GAD reporting sleep difficulties. The good news is that there are several lifestyle changes you can make to improve your sleep while taking Lexapro. Here are some strategies to consider:
Establish a Consistent Sleep Routine
Maintaining a regular sleep schedule is crucial for improving sleep quality. This includes going to bed and waking up at the same time each day, even on weekends. Having a set time to start winding down before bed is also essential. Finding ways to relax during this wind-down period can help signal to your body that it's time to prepare for sleep. Some relaxation techniques to consider include reading, listening to soft music or a podcast, meditation, taking a hot bath, deep breathing, or visualization.
Create a Sleep-Conductive Environment
Your sleep environment plays a significant role in the quality of your sleep. It's important to make your bedroom a quiet, cool, and comfortable space. Consider using earplugs or a white noise machine if you live in a noisy environment. Additionally, avoid electronic devices at least an hour before bed, as the blue light emitted by screens can interfere with sleep.
Exercise Regularly and Maintain a Healthy Diet
Consistent physical activity during the day can promote better sleep quality. However, avoid vigorous exercise within 90 minutes of bedtime, as it may interfere with your ability to fall asleep. In addition to exercise, a healthy diet is crucial for improving sleep. Avoid large meals close to bedtime, and limit caffeine, alcohol, and nicotine consumption, as these substances can act as stimulants and disrupt your sleep.
Manage Stress and Anxiety
Anxiety, worry, and stress can significantly impact sleep quality. Talking to someone you trust or writing about your concerns in a notebook can help manage these feelings. Making a to-do list for the next day can also help calm your mind and improve your sleep. Additionally, natural sleep aids containing melatonin or valerian root may be helpful in promoting sleep, but it's always recommended to consult your doctor before taking any new supplement or medication.
Remember, it's important to be patient when making lifestyle changes. Give yourself time to adjust to your new routines and explore different techniques to discover what works best for you.
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Frequently asked questions
Some over-the-counter sleep aids that are generally considered safe to take with Lexapro include diphenhydramine, doxylamine, melatonin, and valerian root. Common prescription sleep aids that can be taken with Lexapro include trazodone, eszopiclone, and zolpidem.
Taking doxylamine with Lexapro may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impaired thinking, judgment, and motor coordination.
Alcohol can increase the nervous system side effects of Lexapro, such as dizziness, drowsiness, and difficulty concentrating. Alcohol can also disrupt sleep, leading to fragmented sleep in the long run.
Some tips to improve sleep while taking Lexapro include taking the medication in the morning, avoiding caffeine and alcohol before bed, exercising regularly, and maintaining a consistent sleep schedule.
If you experience insomnia or other sleep issues while taking Lexapro, it is recommended to consult your healthcare provider. They can advise on adjusting your dosage, prescribe a different medication, or recommend a suitable sleep aid.










































