
Sleep is an essential part of staying healthy, and a lack of sleep can cause a range of problems beyond fatigue. While good sleep habits, over-the-counter remedies, and prescription medication can help with sleep, it's important to be aware of the potential side effects and risks associated with different options. Prescription sleeping pills, for example, can cause constipation, muscle weakness, and digestive problems, and there is a risk of dependence and addiction. With that in mind, what is the safest prescription sleeping pill?
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What You'll Learn

Prescription sleeping pills vs. over-the-counter (OTC) sleep aids
Sleeping pills can be purchased over the counter (OTC) or with a prescription. OTC sleep aids are easily accessible, and no prescription is required. However, it is recommended that you consult a healthcare provider before taking them. Prescription sleeping pills, on the other hand, are stronger than OTC sleep aids and require a prescription from a healthcare provider. Providers generally do not recommend using prescription sleeping pills long-term due to the risk of dependence and addiction.
OTC sleep aids
OTC sleep aids are readily available at drugstores and retail locations. They often contain antihistamines, which treat allergies but can also cause drowsiness. Common ingredients in antihistamine sleep aids include diphenhydramine and doxylamine. It is important to note that antihistamine medications can cause side effects such as blurred vision, confusion, constipation, and trouble urinating. Additionally, older adults should exercise caution when taking diphenhydramine due to an increased risk of serious side effects, including a higher risk of falls.
Other OTC sleep aids include natural supplements such as melatonin and valerian. Melatonin is a hormone naturally produced by the body to regulate the sleep-wake cycle, while valerian is an herb that is believed to aid relaxation and sleep. It is important to note that supplements are not regulated as strictly as other medications, so there may be uncertainty about the accuracy of the label information.
Prescription sleeping pills
Prescription sleeping pills are typically recommended for short-term relief and are not intended as a long-term solution for insomnia. They work in different ways, such as stimulating the GABA chemical in the brain, leading to sedation, muscle relaxation, and reduced anxiety. Examples of prescription sleeping pills include benzodiazepines (benzos) and Z-drugs like zolpidem (Ambien) and eszopiclone (Lunesta). However, benzodiazepines can be addictive, so healthcare providers usually prescribe Z-drugs instead for short-term use.
Both OTC sleep aids and prescription sleeping pills have their advantages and considerations. OTC sleep aids are easily accessible and can provide short-term relief, but it is important to consult a healthcare provider before taking them, especially when considering long-term use. Prescription sleeping pills, on the other hand, are stronger and may be recommended for short-term relief, but they carry a risk of dependence and addiction. It is always advisable to discuss your specific situation with a healthcare professional to determine the most suitable option for you.
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Side effects of prescription sleeping pills
While sleeping pills can be effective in treating insomnia, they can also have several side effects. These side effects can vary depending on the type of pill and the individual's body. It is always advisable to consult a healthcare provider before taking any medication, including over-the-counter sleep aids.
Over-the-counter and prescription sleeping pills can cause constipation, diarrhoea, muscle weakness, and digestive problems such as gas, heartburn, and nausea. They may also worsen snoring and sleep apnea, and long-term use can lead to rebound insomnia, where the insomnia returns worse than before. Additionally, there is a risk of dependence and addiction, especially with prescription sleeping pills, and it may take months to safely stop taking them.
Sleeping pills can cause daytime drowsiness, muddled thinking, and dizziness, impacting the ability to drive or perform daily tasks. They may also cause balance problems, especially in older adults, increasing the risk of falls and hip fractures.
In rare cases, sleeping pills can lead to parasomnia, a disruptive sleep disorder where individuals may sleepwalk, eat, or even drive without being fully awake, posing significant risks. Long-term use of sleeping pills has been associated with adverse effects on brain function, structural changes in sleep, and an increased risk of depression, particularly in patients with liver and kidney disease.
While overdose is rare, it can be deadly, and mixing sleep aids with other sedatives or alcohol increases this risk. Therefore, it is crucial to exercise caution and follow the advice of a healthcare professional when taking sleeping pills.
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Safety concerns and risks of prescription sleeping pills
While prescription sleeping pills can be effective in treating insomnia and sleep disturbances, they are associated with several safety concerns and risks. Firstly, prescription sleeping pills are typically recommended for short-term relief and are not intended for long-term use. Prolonged use can lead to dependence and addiction, and abruptly stopping the medication can result in rebound insomnia, making it challenging to fall or stay asleep without the pills. Additionally, mixing prescription sleeping pills with other medications, especially those affecting the central nervous system, can have dangerous consequences. The risk of interaction is particularly high with opioids, other sedatives, and alcohol, increasing the possibility of depressed breathing and even overdose.
Prescription sleeping pills have also been associated with a range of side effects, including constipation, muscle weakness, digestive problems, and daytime drowsiness, which can negatively impact daily functioning. In some cases, they may cause more serious side effects, such as burning or tingling sensations in the extremities, and they can worsen snoring and sleep apnea, a potentially life-threatening condition. For individuals with certain health conditions, such as asthma or other chronic lung problems, sleeping pills can interfere with normal breathing, posing a significant risk.
Parasomnia, a disruptive sleep disorder, is another potential risk associated with prescription sleeping pills. Individuals may engage in complex sleep behaviours, such as sleepwalking, eating, or even driving, while appearing awake but with their brain still in a state of reduced alertness. Benzodiazepines, a common type of prescription sleeping pill, carry an additional risk of addiction and substance use disorder, reinforcing the importance of short-term and cautious use.
Over-the-counter (OTC) sleep aids, while more readily accessible, are not without their risks. They can interfere with other medications, and prolonged use can lead to psychological dependence, making it challenging to fall asleep without them. It is always advisable to consult a healthcare provider before taking any sleep aid, whether prescription or OTC, to ensure safe and appropriate use. While prescription sleeping pills can provide temporary relief, they are not a cure for insomnia, and addressing the underlying causes of sleep disturbances is crucial for long-term improvement.
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Natural sleep aids and remedies
While prescription sleeping pills are an option for treating insomnia and other sleep disturbances, they are not a cure for insomnia and carry a risk of dependence and addiction. Natural sleep aids and remedies can be effective in improving sleep without the same risks as prescription medications. Here are some natural options to consider:
Melatonin
Melatonin is a hormone naturally produced by the body that promotes sleep. Melatonin supplements have become a popular sleep aid, as they can reduce the time it takes to fall asleep and may increase sleep duration. Melatonin is particularly useful for individuals experiencing jet lag or sleep disorders. It is available over the counter, but it is important to note that dosages and ingredients may differ between brands.
Valerian
Valerian is an herb that is believed to aid relaxation and promote sleep. It has a calming effect on the nervous system and does not appear to be addictive. However, some people report a stimulating effect with valerian.
Magnesium
Magnesium is a mineral that has been found to possess sleep-promoting properties.
Lavender
Lavender is a popular herbal remedy known for its calming and soothing fragrance, which can aid in relaxation and sleep.
Chamomile
Chamomile is a traditional herbal sleep remedy with a long history of use. German chamomile is commonly consumed as a tea, while Roman chamomile can be taken as a tincture. Both varieties are believed to have a calming effect, helping individuals feel relaxed and prepared for sleep.
In addition to these natural supplements, there are several lifestyle adjustments you can make to improve your sleep:
- Keep your bedroom cool and well-ventilated. The ideal temperature range for optimal sleep is between 65 and 72 degrees Fahrenheit.
- Avoid exposure to bright lights before bed, especially from electronic devices like phones, laptops, or TVs. If you need to get up during the night, use a flashlight instead of turning on the lights.
- Avoid consuming alcohol, as it can disrupt sleep. Instead, try drinking warm milk, chamomile tea, or tart cherry juice before bed.
- Refrain from working out within two hours of your bedtime.
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When to consider prescription sleeping pills
Sleeping pills are available over the counter (OTC), as natural supplements, or by prescription. Prescription sleeping pills are stronger than over-the-counter ones, and you need a prescription from a healthcare provider to obtain them. Providers do not typically recommend using prescription sleeping pills long-term because they are not a cure for insomnia and carry a risk of dependence and addiction. They may help in some cases, but providers will usually only prescribe them for short-term relief.
Over-the-counter sleep aids are easily accessible and can be purchased without a prescription. However, it is important to consult with a healthcare provider before taking them as they can interfere with other medications or aggravate existing health conditions. Most OTC sleeping pills contain antihistamines, which work by blocking histamines that cause alertness. Common ingredients in antihistamines include diphenhydramine and doxylamine.
Natural sleep aids, such as melatonin and valerian supplements, are also available. Melatonin is a hormone naturally produced by the body that promotes sleep. Valerian is an herb that aids relaxation and sleep.
When considering prescription sleeping pills, it is important to weigh the potential benefits against the risks and side effects. Sleeping pills can cause a range of side effects, including constipation, muscle weakness, digestive problems, and worsened snoring and sleep apnea. Additionally, there is a risk of rebound insomnia, where insomnia may return worse than before if the medication is stopped abruptly.
Prescription sleeping pills may be considered in cases of chronic insomnia or sleep disturbances. Healthcare professionals may recommend specific medications based on an individual's needs, such as whether they have difficulty falling asleep or staying asleep. It is important to discuss the full medical history and any potential side effects with a healthcare provider before taking any sleep medication.
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Frequently asked questions
There is no one-size-fits-all answer to this question as different people may experience different side effects with the same medication. It is important to consult a doctor to discuss prescription sleeping pills and find the one that is safest for you.
Some prescription sleeping pills that your doctor may prescribe are Restoril, estazolam (Prosom), eszopiclone (Lunesta), zolpidem (Ambien), zaleplon (Sonata), and ramelteon (Rozerem).
Prescription sleeping pills can have various side effects, including constipation, muscle weakness, digestive problems, worsened snoring, and sleep apnea. Sleeping pills can also cause a hangover effect the next day, with approximately 8 out of 10 people experiencing side effects such as drowsiness or dizziness.
Yes, there are over-the-counter (OTC) sleep aids and natural sleep aids that can help improve sleep. However, it is important to consult your healthcare provider before taking any sleep aids as they can interfere with other medications or health conditions. Some natural sleep aids include melatonin and valerian supplements.








































