
Sleeping pills are depressant medications that slow down the body's functions by acting on the central nervous system. While modern sleeping pills are generally safer than their predecessors, it is still possible to overdose on them, and this can be fatal. Overdosing on sleeping pills can occur when a person takes 60 to 90 times the intended dose, and the risk is greater when a person takes more than their prescribed dose or combines sleeping pills with other substances like opioids or alcohol. In addition, long-term use of sleeping pills has been linked to a higher early mortality rate and decreased life expectancy.
| Characteristics | Values |
|---|---|
| Possibility of overdose | Yes |
| Possibility of death from overdose | Yes |
| Drugs that can cause overdose | Ambien, Lunesta, Sonata, Rozerem, Belsomra, Silenor, barbiturates, benzodiazepines, acetaminophen, aspirin, diphenhydramine, melatonin |
| Factors that can lead to overdose | Misuse, accidental ingestion, intentional self-harm, combining with other substances, dependence, tolerance, mental health issues |
| Symptoms of overdose | Similar to alcohol overdose, slowing of brain function, bluish tinge to lips, fingers and skin, drowsiness, memory loss, strange behaviour, respiratory failure |
| Treatment for overdose | Flumazenil, stomach pump, calling 911, keeping the person awake and talking, placing them in the recovery position |
| Preventative measures | Taking only as prescribed, consulting a professional healthcare provider, seeking treatment for addiction |
| Statistics | 8.4% of American adults took sleep medication for 30 days in 2020, 59% of older adults take nonprescription sleep aids, 60% of people who take benzodiazepines for longer than six months experience withdrawal symptoms, 3.70% of all deaths in New Jersey are from drug overdoses |
What You'll Learn

What factors can cause a sleeping pill overdose?
It is possible to overdose on sleeping pills, and many people die each year from doing so. Sleeping pills are central nervous system depressants, slowing down brain activity to help people rest. An overdose may occur when a person takes 60–90 times the intended dose.
There are several factors that can cause a sleeping pill overdose:
- Taking a higher dose than prescribed: Taking more than the prescribed amount increases the risk of overdose.
- Frequency of use: Taking sleeping pills more often than directed can also lead to overdose.
- Mixing with other substances: Combining sleeping pills with other substances, such as opioids, alcohol, or other depressants, can increase the risk of overdose and enhance the severity of its effects.
- Addiction: Long-term use of sleeping pills can lead to physical dependence and addiction. This may result in taking higher doses or more frequent doses, increasing the risk of overdose.
- Mental health issues: People with serious depression or untreated mental illnesses may be at a higher risk of intentionally overdosing on sleeping pills or mixing them with other substances.
- Side effects: Sleeping pills can cause side effects such as parasomnias (complex sleep behaviours) and memory loss. These side effects can be dangerous and may lead to an increased risk of overdose if they are not addressed.
- Lack of awareness: Some individuals may not be fully aware of the potential dangers and adverse effects of sleeping pills, especially when taking over-the-counter medications. This lack of knowledge can increase the risk of overdose.
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How common are sleeping pill overdoses?
Sleeping pills are central nervous system depressants that slow down brain activity to help people rest. While modern sleeping pills are safer than their predecessors, it is still possible to overdose on them. Overdoses often lead to death and can be accidental or intentional. Accidental overdoses can occur when an individual takes too much of the drug or combines it with other drugs that strengthen its depressive effects. Intentional overdoses, on the other hand, are often suicide attempts.
It is important to note that taking a higher dose than prescribed or taking pills more frequently than prescribed can increase the risk of overdose. Additionally, mixing sleeping pills with other substances, such as opioids or alcohol, can be dangerous and increase the likelihood of an overdose.
The dangerous side effects of misusing sleeping pills can occur even before an overdose happens. Sleep-induced injuries, vehicle accidents due to impaired judgment and coordination, and crimes and self-harm have all been linked to the use of sleeping medications.
While the exact incidence rate of sleeping pill overdoses is unclear, it is known that millions of individuals use sleep aids each year. Additionally, a report from the National Institute on Drug Abuse (NIDA) stated that drug overdose deaths have increased consistently since 1999, with more than 64,000 deaths reported in 2016. Furthermore, sedative drugs, including barbiturates and benzodiazepines (common sleeping pills), were noted as some of the main causes by rehab centres.
The likelihood of fatal overdoses from sleeping pills has decreased over time as researchers have made these medications safer. Additionally, newer sleep-inducing drugs are less potent and formulated to be safer and less likely to result in fatal overdoses. However, it is important to note that even these newer drugs are not 100% safe, and high doses can still be fatal.
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What are the signs of a sleeping pill overdose?
Sleeping pills are central nervous system depressants, slowing down brain activity to help people rest. While modern sleeping pills are safer than their predecessors, it is still possible to overdose. Overdoses can lead to death, especially when pills are mixed with other substances like opioids or alcohol.
Recognising the signs of a sleeping pill overdose is critical. The physical signs of a sleeping pill overdose can include extreme lethargy, confusion, shallow or difficulty breathing, decreased heart rate, and loss of coordination or clumsiness. More severe signs can include unconsciousness or coma. Some people might also experience nausea, vomiting, or abdominal pain. If you suspect an overdose, call emergency services immediately.
Sleeping pill overdose can also result in abnormal heart rhythms, low blood pressure, and potential heart failure. Excessive sedation from an overdose can cause confusion and dizziness and can lead to comas or long-term cognitive impairment. In some cases, it may be necessary to use flumazenil to counter the effects of a sleeping pill overdose, as well as removal with a stomach pump.
Sleeping pills can be addictive, and the longer an individual takes them, the more the body adjusts to their presence. This can lead to a higher tolerance and the need for increased doses to achieve the desired effects. Mixing sleeping pills with other substances is especially dangerous and increases the risk of overdose.
It is important to take sleeping pills only as directed by a healthcare provider and to be aware of the signs of overdose to get timely medical help.
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How do sleeping pills work?
Sleeping pills are central nervous system depressants that slow down brain activity to help you rest. They are designed to treat insomnia by making you feel drowsy and relaxed. They work on the GABA receptors in the brain, which help control our level of alertness or relaxation. The selective GABA medications target only a certain type of GABA receptor, one believed to be more dedicated to promoting sleep.
Sleeping pills are available over the counter (OTC), as natural supplements, or by prescription. Anyone over the age of 18 can buy OTC sleep medications at drugstores or other retail locations without a prescription. Most OTC sleeping pills contain antihistamines, which treat allergies but can also make you drowsy. Some people take natural remedies like melatonin or valerian supplements to help them sleep. Melatonin is a synthetic drug that mimics the same hormone in the brain, which stimulates sleep onset and is responsible for the sleep cycle.
Prescription sleeping pills are stronger than OTC ones and are typically recommended for short-term relief. They include benzodiazepines, tricyclic antidepressants (TCAs), and Z-drugs like zolpidem (Ambien) and eszopiclone (Lunesta). Z-drugs are fast-acting, taking effect within 30 minutes and lasting up to 8 hours. They induce sleepiness, calm anxiety, and promote sound sleep without leaving you feeling groggy in the morning.
While sleeping pills can be effective in treating insomnia, they also come with risks. Overdosing on sleeping pills can occur when a person takes 60–90 times the intended dose, and it can lead to death. Mixing sleeping pills with other substances like opioids or alcohol can further increase the risk of overdose and fatal outcomes. Additionally, there is a risk of dependence and addiction, especially with long-term use. It is important to follow the prescribed dosage and be aware of potential side effects when taking sleeping pills.
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What are the risks of taking sleeping pills?
Sleeping pills are prescription medications containing tranquilizers to treat insomnia, restless sleep, or difficulty falling asleep. While modern sleeping pills are safer than their predecessors, there are still risks associated with their use. Firstly, it is possible to overdose on sleeping pills, especially if one takes a higher dose than prescribed or takes pills more frequently than prescribed. Additionally, mixing sleeping pills with other substances such as opioids, sedatives, or alcohol can increase the risk of overdose and enhance the sedative effects of the pills. Overdosing on sleeping pills can lead to various outcomes, including death, and can be accidental or intentional in nature. Therefore, it is crucial to take sleeping pills only as prescribed and to be cautious when mixing them with other substances.
Another risk of taking sleeping pills is the potential for side effects. Sleeping pills can cause daytime sleepiness, dizziness, confusion, memory issues, and balance problems. These side effects can impact an individual's ability to drive or operate machinery safely. Additionally, there is a risk of developing a dependence on sleeping pills, which can lead to psychological dependence and difficulty sleeping without the medication. Abruptly discontinuing sleeping pills can result in rebound insomnia, and it is recommended to gradually taper off the medication under medical supervision.
Furthermore, sleeping pills can interact with other medications, particularly those that affect the central nervous system. It is important to inform your doctor about any other medications or supplements you are taking to avoid potential drug interactions. Sleeping pills may also not be suitable for everyone, especially pregnant or breastfeeding individuals, as the medication can pass to the fetus or baby. Additionally, older adults and children may be at a higher risk of adverse effects, and it is recommended to explore non-drug treatments before considering sleeping pills for these populations.
Sleeping pills have also been associated with complex sleep behaviors known as parasomnias. These behaviors include sleep eating, making phone calls, or even driving while not fully awake. Parasomnias can be dangerous and challenging to detect once the medication takes effect. Additionally, certain sleeping pills may have specific risks associated with them. For example, benzodiazepines, a powerful class of sleeping pills, can be addictive and lead to substance use disorders. Therefore, it is important to carefully consider the benefits and risks of taking sleeping pills and to follow the advice of a healthcare professional.
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Frequently asked questions
Yes, it is possible to overdose on sleeping pills. Overdoses often lead to death. An overdose occurs when someone takes more than the recommended dose of sleep medication.
Sleeping pills are central nervous system depressants that slow down the body's functions. When a person overdoses, the drug can begin to affect involuntary functions, such as breathing and heart rate, leading to respiratory failure and even death.
If you suspect that someone has overdosed on sleeping pills, call 911 immediately. Keep the person awake and talking if possible until help arrives. If the person is unconscious, place them in the recovery position and wait for help.

