
ZzzQuil and Benadryl are over-the-counter sleep aids that can help with short-term sleep problems. They have the same active ingredient, diphenhydramine, which is an antihistamine that treats allergy symptoms such as itchiness, watery eyes, and sneezing. However, one of the side effects of diphenhydramine is sleepiness, making it a popular ingredient in sleep aids. While both ZzzQuil and Benadryl can help with occasional sleeplessness, it's important to carefully follow the package instructions and recommended doses to avoid potential side effects like next-day drowsiness and grogginess.
| Characteristics | Values |
|---|---|
| Active ingredient | ZzzQuil: Diphenhydramine |
| Benadryl: Diphenhydramine | |
| Side effects | ZzzQuil: Next-day sleepiness |
| Benadryl: Next-day sleepiness, altered mental state, urinary retention, dry mouth | |
| Use | ZzzQuil: Short-term relief of occasional sleeplessness |
| Benadryl: Short-term treatment for insomnia | |
| Dosage | ZzzQuil: 50 mg, taken 30 minutes before bedtime |
| Benadryl: 50 mg, taken 30 minutes before bedtime | |
| Warnings | ZzzQuil: Stop use and consult a doctor if sleeplessness persists after two weeks |
| Benadryl: No warning on the packaging |
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What You'll Learn

ZzzQuil and Benadryl have the same active ingredient
Diphenhydramine is commonly sold under the brand name Benadryl. You can also find it in nighttime pain relief medications, such as Advil PM or Tylenol PM, and it's the main ingredient in ZzzQuil products. Diphenhydramine comes in several forms, including tablets, capsules, powders, and liquids. While it's generally safe to use, diphenhydramine can have serious side effects if taken in larger-than-recommended doses. It is important to note that diphenhydramine can be used for short-term sleep problems for up to 2 weeks. However, it is not recommended for long-term use as a sleep aid.
ZzzQuil is a brand name for diphenhydramine that is specifically marketed as a sleep aid. The manufacturers of ZzzQuil recommend that you only take it if you know you'll have enough time to get a full night's rest. They also advise consumers to stop use and consult a doctor if they're still having trouble sleeping after two weeks. On the other hand, Benadryl is marketed as an antihistamine for allergy relief, with “marked drowsiness" listed as a potential side effect.
Although ZzzQuil and Benadryl have the same active ingredient and similar side effects, individual preferences may vary due to the presence of different inactive ingredients in the two products. Inactive ingredients can affect the taste, color, ease of active ingredient delivery, and other factors of a drug, leading some people to prefer one product over the other. It is important to carefully read the package instructions for both ZzzQuil and Benadryl, as the directions for use may differ.
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ZzzQuil is marketed as a sleep aid, Benadryl is not
ZzzQuil and Benadryl both contain the same active ingredient, diphenhydramine, a type of antihistamine. Antihistamines are commonly used in allergy medications as they can help to alleviate symptoms such as itchiness, watery eyes, and sneezing. However, one of the side effects of antihistamines is drowsiness, which is why they are often used as short-term sleep aids. While Benadryl is marketed as an antihistamine to treat allergies, ZzzQuil is specifically marketed as a sleep aid for "the relief of occasional sleeplessness".
The fact that ZzzQuil and Benadryl contain the same active ingredient means that they essentially work in the same way. However, ZzzQuil is indicated for sleep and comes with specific instructions and warnings related to its use as a sleep aid. For example, ZzzQuil's warning label advises consumers to stop use and consult a doctor if they are still having trouble sleeping after two weeks. On the other hand, Benadryl does not contain any such warnings, even though experts agree that it is not suitable for long-term use.
The marketing of ZzzQuil as a sleep aid, rather than an antihistamine, is due to the way over-the-counter drugs are regulated by the FDA. The FDA reviews OTC drugs through drug monographs, which outline the acceptable ingredients, dosage, and usage of a drug. In the case of diphenhydramine, there are two monographs: one stating that it can be taken at 25mg or 50mg for allergies, and another stating that it can be taken at 50mg as a sleep aid. This allows ZzzQuil to be marketed specifically as a sleep aid, while Benadryl is marketed for the treatment of allergies.
It is important to note that while antihistamines like Benadryl and ZzzQuil can be effective in inducing sleep, they may also cause next-day drowsiness and other side effects such as an altered mental state, urinary retention, and dry mouth. These side effects are generally mild and well-tolerated in young, healthy individuals but can pose a risk, especially for the elderly. Additionally, many people develop a tolerance to antihistamines quickly, and they may not be effective for long-term use. Therefore, it is recommended that individuals experiencing long-term insomnia consult a physician or sleep specialist to address the underlying causes of their sleep issues.
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Benadryl is an antihistamine meant to treat allergic reactions
Benadryl is an antihistamine, a class of drugs that treat allergies. Antihistamines work by counteracting histamine in the body. Histamine is a chemical that produces the inflammatory response behind allergy symptoms, but it also plays a key role in promoting wakefulness. When antihistamines counteract histamine in the body, they have the side effect of making you feel tired. Benadryl lists "marked drowsiness" as a potential side effect, and it is often used as a short-term treatment for insomnia. However, using Benadryl or any antihistamine for sleep has no long-term benefits, and most people develop a tolerance very quickly. In addition, antihistamines can have side effects such as an altered mental state, urinary retention, and dry mouth. While these side effects are generally mild and well tolerated in young patients without other medical problems, they can pose a risk, especially for the elderly.
Benadryl is commonly sold under the brand name Benadryl, but it can also be found in nighttime pain relief medications such as Advil PM or Tylenol PM. It comes in several forms, including tablets, capsules, powders, and liquids. While it's generally safe to use, Benadryl can have serious side effects if taken in larger-than-recommended doses. It is important to follow the package instructions carefully, as the directions for use may vary depending on whether it is being used for allergies or sleep. The typical dose of Benadryl for sleep is 50 mg, taken 30 minutes before bedtime.
ZzzQuil is a sleep aid product that contains the same active ingredient as Benadryl, diphenhydramine. ZzzQuil is marketed specifically as a sleep aid, while Benadryl is marketed as an antihistamine for allergy relief. However, both products essentially work the same way and have the same potential side effects, such as next-day sleepiness. It is important to note that ZzzQuil is indicated for "the relief of occasional sleeplessness," and consumers are advised to stop use and consult a doctor if they still have trouble sleeping after two weeks.
When deciding whether to take Benadryl or ZzzQuil as a sleep aid, it is important to consider the potential side effects and warnings associated with each product. Both products can cause next-day drowsiness, so it is important to ensure you have a full night's sleep of 7-9 hours when taking them. In addition, while sporadic use of the recommended daily dose of these drugs typically won't have serious medical repercussions for a healthy adult, it is important to seek treatment for underlying insomnia if you feel the need to take a sleep aid every night.
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Doxylamine and diphenhydramine have similar side effects
Doxylamine and diphenhydramine are both antihistamines that can be used as sleep aids for short-term sleep problems. They are considered similar in potency, despite the number of milligrams differing between the two drugs. Doxylamine is typically taken at a lower dose than diphenhydramine because its effects last longer in the body.
Both drugs may also increase the risk of liver and kidney dysfunction, drug interactions, and worsened side effects. It is important to carefully read the instructions on the package and not exceed the recommended dosage for either drug.
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Sleep aids can cause next-day drowsiness
Sleep aids like Benadryl and ZzzQuil can cause next-day drowsiness. Benadryl (diphenhydramine) is an antihistamine commonly used to treat allergies. However, one of its side effects is sleepiness, so it's often used as a short-term treatment for insomnia. ZzzQuil contains the same active ingredient as Benadryl, but it is marketed specifically as a sleep aid.
While these medications can help people fall asleep, they can also cause grogginess and a "hangover effect" the next day. This effect can impact activities like driving or working and may last several hours after waking up. The drowsiness is caused by the antihistamine blocking histamine, a chemical that promotes wakefulness in the body.
Doxylamine, another common sleep aid ingredient found in Unisom, has similar effects to diphenhydramine but stays in the system longer, potentially increasing the risk of next-day drowsiness. For this reason, it is recommended that people taking sleep aids ensure they get a full night's sleep of 7 to 9 hours and do not have important tasks or activities the next day.
While occasional use of sleep aids may not have serious medical repercussions for healthy adults, long-term use is not recommended. People who suffer from long-term insomnia are advised to consult a physician or sleep specialist to address the underlying causes of their sleep issues.
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Frequently asked questions
The active ingredient in Benadryl is diphenhydramine, an antihistamine that treats symptoms of an allergic reaction like itchiness, watery eyes, and sneezing. ZzzQuil also contains diphenhydramine, except for one product that contains melatonin.
Both drugs can cause next-day sleepiness or drowsiness. Other side effects include an altered mental state, urinary retention, and dry mouth.
The typical dose of doxylamine is 25mg, taken 30 minutes before bedtime. The typical dose of diphenhydramine is 50mg, taken 30 minutes before bedtime.
While sporadic use of the recommended daily dose of these drugs typically won't have serious medical repercussions for healthy adults, long-term use is not advised. Experts caution against using antihistamines as sleep aids, as they have no long-term benefit and can cause a "hangover effect" of grogginess the next day.









































