
Sleep is an essential part of our lives, and sleep disorders are common. Medication can help people fall asleep, stay asleep, or both. However, sleep medication often comes with risks, side effects, and the potential for misuse and dependency. Before taking any sleep medication, it is important to consult a doctor. Some common sleep medications include Lunesta, Ambien, and Sonata, which are non-benzodiazepine medications (z-drugs). Other medications include doxepin (Silenor), Ramelteon (Rozerem), and Temazepam. Natural sleep aids such as melatonin are also available over the counter.
| Characteristics | Values |
|---|---|
| Brand Name | Silenor, Rozerem, Lunesta, Ambien, Sonata |
| Drug Name | Doxepin, Ramelteon, Estazolam, Zolpidem, Eszopiclone, Zaleplon |
| Availability | Over-the-counter, prescription |
| Dosage | 3mg, 6mg, 8mg, 150mg, 25mg-100mg, 400mg |
| Side Effects | CNS depression, dizziness, nausea, drowsiness, grogginess, dry mouth, edema, increased thoughts of suicide, rebound insomnia |
| Risk Factors | Alcohol consumption, history of substance abuse, depression, other mood problems, pregnancy, glaucoma, urinary retention |
| Treatment Length | Short-term, long-term |
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What You'll Learn

Prescription vs over-the-counter sleep aids
Sleeping pills are available over the counter (OTC), as natural supplements, or by prescription. Prescription sleeping pills are generally stronger than over-the-counter ones, and they require a prescription from a healthcare provider. Providers do not typically recommend using prescription sleeping pills long-term because they are not a cure for insomnia and there is a risk of dependence and addiction. They may help in some cases, but providers will usually only prescribe them for short-term relief.
Over-the-counter sleep aids are best for short-term use, such as overcoming a brief bout of sleeplessness or coping with jet lag. They are not recommended for long-term chronic insomnia. If your sleep troubles last for more than a week, consult a doctor to check for underlying problems such as sleep apnea, stress, or anxiety. Doctors may suggest additional interventions, such as prescription sleep aids or cognitive-behavioral therapy, which can help with insomnia.
OTC sleep aids often contain antihistamines, which can cause side effects such as daytime drowsiness, dry mouth, blurry vision, constipation, and trouble urinating. Melatonin is another common ingredient in OTC sleep aids. It is a synthetic version of a hormone naturally produced by the body to regulate the sleep-wake cycle. Valerian, an herb that supposedly aids relaxation and sleep, is also available as a supplement.
Prescription sleep aids include antidepressants, barbiturates, benzodiazepines, and Z-drugs such as zolpidem (Ambien) and eszopiclone (Lunesta). Benzodiazepines can be addictive and are typically prescribed for short-term use. Doxepin (Silenor) is a tricyclic antidepressant that is FDA-approved for treating insomnia characterised by difficulty staying asleep. It is only available by prescription but is not a controlled substance. Suvorexant (Belsomra) may help a person fall asleep and maintain sleep, but it is only available as a brand-name medication. Ramelteon (Rozerem) is a melatonin antagonist that may help a person fall asleep, and doctors may prescribe it for longer-term use.
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Doxepin (Silenor) for insomnia
Doxepin, also known by its brand name Silenor, is a tricyclic antidepressant that is FDA-approved for treating insomnia characterised by difficulty staying asleep. It is available as an immediate-release tablet in 3 and 6-milligram doses. Doctors may suggest people with insomnia use Silenor for up to 3 months. It is important to note that Silenor is not meant for those taking monoamine oxidase inhibitors, a type of antidepressant, or people with glaucoma or urinary retention.
Doxepin can be taken 30 minutes before bedtime, and it may take 7 to 10 days for insomnia symptoms to improve. It is important to limit activities after taking the medication to getting ready for bed, as Doxepin can cause drowsiness and dizziness, which can lead to falls or accidents. It is also advised to avoid driving or operating heavy machinery until you know how Doxepin affects you. Additionally, Doxepin can make your skin more sensitive to light, so it is important to take precautions if you need to be in the sun.
It is crucial to consult a doctor before taking Doxepin, especially if you have a history of substance abuse, depression, or other mood problems. This medication may also cause central nervous system (CNS) depression, where brain activity slows down. It is not recommended for women who are pregnant or breastfeeding, as it can have harmful effects on infants. Furthermore, Doxepin should not be taken within 3 hours of a meal, and it is important to avoid alcohol consumption while taking this medication, as it can increase the effects of alcohol.
While less common, serious side effects of Doxepin can include severe allergic reactions and, in a small number of cases, an increased risk of suicidal thoughts or actions in children, teenagers, or young adults. It is important to weigh the risks and benefits of taking this medication and consult a healthcare professional if you experience any adverse effects.
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Ramelteon (Rozerem) for falling asleep
Ramelteon, also known by its brand name Rozerem, is a melatonin receptor agonist that helps people fall asleep. It is a prescription sleep medication that is not habit-forming and is not a controlled substance, meaning it has a low likelihood of misuse or dependency. This makes Ramelteon suitable for longer-term use, unlike other sleep medications. It is typically prescribed for adults experiencing insomnia, specifically those who have trouble falling asleep.
Ramelteon is a hypnotic sedative that works by mimicking the effects of melatonin, a natural hormone produced by the body in response to darkness, signalling that it is time to sleep. By affecting melatonin receptors, Ramelteon promotes sleep and positively affects circadian rhythms. The recommended dose is 8mg taken orally about 30 minutes before bedtime, with a glass of water. It should be taken on an empty stomach to aid absorption and help you fall asleep faster. It is important to note that Ramelteon should only be taken if you have time for a full night's sleep.
While Ramelteon is generally well-tolerated, it can cause side effects such as drowsiness, dizziness, and tiredness. It may affect your alertness and coordination, even the day after taking it, so it is advised to refrain from driving or engaging in activities that require alertness until you know how the medication affects you. Less commonly, Ramelteon may cause allergic reactions, changes in mood, thoughts, or behaviour, and complex sleep behaviours such as sleepwalking or sleep driving. It is important to discuss any health conditions, medications, and supplements you are taking with your doctor before starting Ramelteon.
Ramelteon may be a suitable option for those seeking a sleeping pill that is not habit-forming and can be used long-term. However, it is always recommended to consult with a healthcare professional to determine the most appropriate treatment for your individual needs and circumstances.
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Zolpidem (Ambien) for rapid sleep onset
Zolpidem, also known by its brand name Ambien, is a medication used to treat insomnia by helping individuals fall asleep faster and stay asleep throughout the night. It is a non-benzodiazepine hypnotic agent, which means it can induce sleep without the same degree of fast-wave activity associated with benzodiazepines, resulting in a sleep pattern that more closely resembles a natural sleep cycle.
Zolpidem is a fast-acting medication, typically making individuals feel sleepy within 15 to 30 minutes to an hour of taking it. It is considered a short-acting hypnotic, meaning its effects wear off fairly quickly, and while it may help with falling asleep, it may not necessarily prolong sleep duration. The standard adult dose is 10mg taken daily for up to four weeks, with the drug taken at bedtime. For the elderly, a lower dose of 5mg daily for up to four weeks is recommended.
Zolpidem-MR, marketed in the United States, is a two-layered tablet designed to help people who wake up in the night. The first layer is released immediately, providing a rapid concentration of zolpidem, followed by the second layer, which provides an extended release of the drug to maintain levels throughout the night. The starting dose of Zolpidem-MR is 12.5mg for adults and 6.25mg for the elderly.
It is important to note that zolpidem should only be used for a short period of time and under medical supervision. It may cause side effects such as drowsiness or dizziness the next day, and caution should be exercised when taking it with other medications, especially those for seizures, sleep, anxiety, muscle relaxation, or opioids. Zolpidem may also lead to unusual sleep behaviours, such as sleepwalking, sleep-driving, or other activities that individuals may not remember the next day. Therefore, individuals taking zolpidem should ensure they can stay in bed for a full night (7 to 8 hours) and refrain from activities requiring full mental alertness for at least 8 hours after taking the medication.
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Suvorexant (Belsomra) for falling and staying asleep
Suvorexant, sold under the brand name Belsomra, is a medication used to treat insomnia in adults. It is an orexin receptor antagonist, meaning it blocks the action of orexin, a chemical in the brain that promotes wakefulness. By blocking orexin from making connections in the brain, Belsomra helps to reduce the time it takes to fall asleep, improves total sleep time, and enhances sleep quality.
Belsomra is taken orally as a tablet, typically 30 minutes before bedtime. The recommended starting dose for adults is 10 mg, which can be increased to 15 mg if well tolerated but still not effective enough. The maximum dosage is 20 mg per night, and it is important to follow the prescribed amount to avoid adverse effects. Belsomra should only be taken when there is time for at least seven hours of sleep, as it can cause sleepiness and drowsiness during the day. It may also lead to complex sleep behaviours, such as sleepwalking, sleep driving, or preparing and eating food while not fully awake. These activities are usually not remembered, but they can be dangerous.
The most common side effect of Belsomra is sleepiness, which may impact the ability to drive or perform tasks requiring alertness or coordination the next day. Other possible side effects include strange dreams, headaches, dizziness, dry mouth, and impaired driving ability. Rarely, Belsomra may cause sleep paralysis, hallucinations, or suicidal thoughts or actions. It is important to consult a healthcare provider before taking Belsomra to ensure it is safe for your individual circumstances and to discuss any potential risks or interactions with other medications.
Belsomra has been approved for the treatment of insomnia by regulatory agencies in the United States, Australia, and Japan. In the United States, the Food and Drug Administration (FDA) has approved doses of 5 to 20 mg, while the Australian Therapeutic Goods Administration (TGA) and Japanese Pharmaceuticals and Medical Devices Agency (PMDA) have approved doses of 15 mg for the elderly and 20 mg for younger adults. Belsomra is a Schedule IV controlled substance in the United States, indicating a low potential for drug abuse and a low risk of dependence. However, it is not recommended for those with a history of depression, mental illness, or suicidal thoughts.
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Frequently asked questions
There is no single best pill for sleep. The choice of medication depends on individual circumstances. Some common sleeping pills for insomnia include Lunesta, Ambien, and Sonata. Other pills such as Doxepin (Silenor) and Ramelteon (Rozerem) can also help with sleep.
Sleep medication can have several side effects including memory problems, falls, and even death. They can also cause next-day drowsiness, nausea, and headaches. Some medications also carry the risk of dependence and misuse.
Sleep medication comes with significant risks and it is best to take them only for short periods. Sleep medication should not be taken with alcohol as it can increase the risk of unintended sleep behaviours.
The safest way to treat insomnia is with good sleep habits and cognitive behavioural therapy. Some natural sleep aids such as melatonin are also available over the counter.
It is important to consult a doctor or healthcare professional before starting any sleep medication. They can help you weigh the benefits and risks of each medication and determine which one is best suited to your needs.










































