
Unisom is an over-the-counter medication that helps promote sleep in adults with insomnia. It is meant to deliver short-term relief for temporary sleep problems and is not intended to be a treatment for insomnia. Unisom contains an antihistamine called diphenhydramine, which blocks the histamine action that can cause alertness in the central nervous system. While it can help with falling asleep, it is not as useful for staying asleep. Unisom may cause side effects such as drowsiness, dizziness, dry mouth, blurred vision, and headaches. It is generally well-tolerated, but older adults have a higher risk of falls and excitation rather than sedation. It is recommended to consult a doctor if sleeplessness lasts for more than two weeks, as long-term sleeplessness may indicate a serious underlying medical condition.
| Characteristics | Values |
|---|---|
| Intended use | Short-term relief for temporary sleep problems |
| Dosage | 25-50 mg, at least 30 minutes before bed |
| Side effects | Dizziness, dry mouth, blurred vision, dry eyes, headaches, drowsiness, daytime grogginess, hallucinations, high feeling |
| Risks | May worsen or precipitate certain medical conditions, including glaucoma, hyperthyroidism, asthma, bladder obstruction, and COPD |
| Precautions | Should not be taken with alcohol or other medications that worsen drowsiness; not suitable for children under 12; avoid if pregnant or breastfeeding |
| Long-term use | May develop tolerance, requiring higher doses; underlying sleep issues may be missed |
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What You'll Learn
- Unisom is an over-the-counter medication that helps with occasional sleeplessness
- It contains an antihistamine called diphenhydramine, which blocks histamine action in the CNS
- Side effects include drowsiness, dry mouth, dizziness, blurred vision, and headaches
- It may cause excitation in the elderly and should be avoided by those with glaucoma
- Long-term use may lead to tolerance and the need for higher doses, with potential negative side effects

Unisom is an over-the-counter medication that helps with occasional sleeplessness
While Unisom is generally well-tolerated, it can cause side effects such as drowsiness, dizziness, dry mouth, blurred vision, and headaches. These side effects are typically mild and resolve on their own, but they can be more severe in older adults, and people with certain medical conditions like glaucoma. Combining Unisom with substances like alcohol, opioids, or benzodiazepines can enhance drowsiness, leading to severe sedation. Therefore, it is crucial to follow the recommended dosage and avoid taking Unisom with other medications or substances that affect the central nervous system.
Unisom is not recommended for children under 12 years of age, pregnant or breastfeeding women, and individuals with specific medical conditions, including glaucoma, hyperthyroidism, asthma, bladder obstruction, and COPD. It is always advisable to consult a healthcare provider before taking Unisom to ensure it is safe and appropriate for your individual circumstances. Additionally, if sleeplessness persists or becomes a frequent occurrence, it is important to seek medical advice as it may indicate an underlying medical condition.
Unisom can be an effective solution for occasional sleeplessness, but it should be used with caution and under the guidance of a healthcare professional to ensure safe and proper usage. While it can help with falling asleep, it may be less effective for staying asleep, and long-term use may lead to tolerance and potential side effects. Therefore, it is crucial to follow the recommended guidelines and explore alternative treatments for chronic insomnia under medical supervision.
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It contains an antihistamine called diphenhydramine, which blocks histamine action in the CNS
Unisom is an over-the-counter medication that promotes sleep in adults with insomnia or occasional sleeplessness. It contains an antihistamine called diphenhydramine, which blocks histamine action in the central nervous system (CNS). Histamine is a natural body chemical that can cause alertness, and by blocking its action, diphenhydramine helps reduce difficulty falling asleep.
Diphenhydramine is the active ingredient in Unisom, and it has been used effectively and safely in Canada for over 50 years. Each Unisom SleepGels Extra Strength capsule and Unisom Extra Strength tablet contains 50 mg of diphenhydramine hydrochloride. The recommended daily dose is 25 to 50 mg, taken by mouth at least 30 minutes before bed. The sedative effects of Unisom can last up to 6 hours, so it's important to ensure a full night's sleep after taking the medication.
While Unisom is non-habit forming, it is still important to use it as directed and only for the short-term relief of temporary sleep problems. If you take Unisom for more than two or three days consecutively, you may develop a tolerance, leading to the need for higher doses to achieve the same effect. This increases the risk of side effects, which can be dangerous and require immediate medical intervention, such as anaphylaxis and blood cell disorders.
Some common side effects of Unisom include drowsiness, dizziness, dry mouth, headaches, and blurred vision. These side effects are typically mild and can be managed at home or resolve on their own. However, older adults are at a higher risk of falls and other adverse events, so experts recommend adults over 65 avoid taking Unisom. Additionally, Unisom should not be taken with alcohol due to the risk of excessive sedation.
If you experience persistent sleep difficulties or if Unisom does not improve your sleep after a few days, consult your doctor or a sleep hygienist. They can help determine if there is an underlying cause for your sleeplessness and recommend alternative treatments if necessary.
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Side effects include drowsiness, dry mouth, dizziness, blurred vision, and headaches
Unisom is a sleep aid medication that can be bought over the counter without a prescription. It is meant to deliver short-term relief for temporary sleep problems. It is recommended that you take Unisom only for a few days at a time and consult a doctor if your sleep problems persist. Unisom contains an antihistamine called diphenhydramine, which blocks the histamine action that can cause alertness in the central nervous system (CNS). While it is non-habit forming, you can develop a tolerance to Unisom if you take it for extended periods.
Some of the common side effects of Unisom include drowsiness, dry mouth, dizziness, blurred vision, and headaches. Drowsiness is a desired effect for most people taking Unisom. However, it can be dangerous if you operate machinery or drive while experiencing drowsiness. Combining Unisom with other medications or substances that increase drowsiness, such as alcohol, opioids, or benzodiazepines, can lead to severe drowsiness. If you experience next-day drowsiness, consider reducing your dosage or consulting your pharmacist for alternative recommendations.
Dry mouth is another common side effect of Unisom. Chewing sugarless gum or sucking on hard candy, and staying hydrated by drinking plenty of water, may help alleviate this symptom. Dizziness is also a known side effect of Unisom. It can be risky if you wake up feeling dizzy, especially when changing positions, such as going from standing to sitting. If you experience dizziness, find a safe place to sit or lie down to prevent losing your balance.
Blurred vision is another potential side effect of Unisom. If you wear contact lenses, you may experience discomfort. Using lubricating eye drops may help alleviate this issue. However, if the problem persists or becomes severe, it is advisable to consult your healthcare provider. Headaches are another mild but common side effect of Unisom. Staying hydrated by drinking water or other fluids and avoiding alcohol can help manage headaches. Additionally, incorporating exercise or increasing movement throughout your day may also provide relief.
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It may cause excitation in the elderly and should be avoided by those with glaucoma
Unisom is an over-the-counter medication that helps promote sleep in adults with insomnia. It is generally well-tolerated, and side effects are typically mild and resolve on their own. However, it is important to be aware of potential risks, especially for older adults.
One of the risks associated with Unisom is that it may cause excitation in the elderly rather than the desired sedation effect. This is because Unisom can produce different effects in older adults, and they have a greater risk of falls compared to younger adults. As a result, experts recommend that adults aged 65 and older avoid taking Unisom, and instead discuss safer alternatives with their healthcare provider.
Additionally, Unisom should be avoided by individuals with glaucoma. While people with narrow-angle glaucoma are at the highest risk, anyone with any type of glaucoma should consult their healthcare provider before taking Unisom or other OTC sleep aids. This is because Unisom can worsen or precipitate glaucoma, along with other medical conditions such as hyperthyroidism, asthma, bladder obstruction, and COPD.
The active ingredient in Unisom, diphenhydramine hydrochloride or doxylamine, is an antihistamine that blocks the action of histamine in the central nervous system, which can cause alertness. While Unisom is effective for occasional sleeplessness due to fatigue or overwork, it is not intended as a long-term solution for insomnia. If sleeplessness persists for more than two weeks, individuals should consult their doctor as it may indicate an underlying medical issue.
It is important to follow the recommended dosage and usage instructions for Unisom to minimize risks and side effects. Unisom should only be taken by adults and children above 12 years of age, and it should not be combined with alcohol or certain other medications that can worsen drowsiness.
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Long-term use may lead to tolerance and the need for higher doses, with potential negative side effects
Unisom is a non-prescription sleep aid that is meant to deliver short-term relief for temporary sleep problems. It is generally well-tolerated, and its side effects are usually mild and resolve on their own. However, long-term use of Unisom may lead to tolerance, which means that higher doses may be required to achieve the same effect. This can increase the risk of negative side effects.
Unisom is recommended for adults experiencing occasional sleeplessness due to fatigue or overwork. It is not intended to be a long-term treatment for insomnia. If sleeplessness lasts for more than two weeks, it is advised to consult a doctor, as it may indicate a serious underlying medical condition.
While Unisom is non-habit forming, taking it for extended periods can lead to tolerance. This means that over time, the body may become accustomed to the medication, resulting in reduced effectiveness. As a result, individuals may find themselves taking higher doses to achieve the desired sedative effect.
The potential negative side effects associated with higher doses of Unisom include dry mouth, dizziness, daytime grogginess, blurred vision, and headaches. Additionally, combining Unisom with certain substances, such as alcohol, opioids, or benzodiazepines, can cause severe drowsiness. Older adults are also at a higher risk of falls while taking Unisom.
It is important to consult a healthcare professional before taking Unisom, especially if it is intended for long-term use. They can advise on the appropriate dosage and help identify any potential underlying sleep issues that may require alternative treatments.
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Frequently asked questions
Unisom is a non-prescription sleep medication that helps people fall asleep. It is meant to deliver short-term relief for temporary sleep problems.
Taking Unisom but still being unable to sleep can lead to an increased dosage to feel its effects. This can result in negative side effects such as dry mouth, dizziness, daytime grogginess, blurred vision, and next-day drowsiness.
If you experience any side effects from taking Unisom, it is recommended to contact your healthcare provider or pharmacist for advice and to determine if Unisom is suitable for you.
Unisom is not recommended for children under 12 years of age and those who are pregnant or breastfeeding unless directed by a doctor. People with glaucoma should also consult a healthcare provider before taking Unisom.
Yes, alternatives to Unisom for sleep issues include prescription sleep medications like zolpidem (generic Ambien) and non-medication insomnia treatments such as using a CPAP machine for sleep apnea.



























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