
Excedrin PM is a non-prescription medication that combines two pain relievers, acetaminophen and aspirin, with a nighttime sleep aid, diphenhydramine citrate. It is marketed as a solution for fast relief from nighttime headaches and sleeplessness. While it is generally regarded as safe for adults, it is not recommended for children under 12 and can cause serious side effects or allergic reactions in some cases. As with any medication, it is important to be aware of potential interactions and side effects before use.
| Characteristics | Values |
|---|---|
| Effectiveness | Excedrin PM is effective for pain relief, particularly for night headaches, and helps people sleep through the night without causing drowsiness in the morning. |
| Dosage | Adults and children aged 12 and above should take 2 caplets at bedtime with a full glass of water. |
| Ingredients | Acetaminophen, aspirin, and diphenhydramine citrate. |
| Side effects | Excedrin PM may cause severe skin reactions and allergies. It may also cause liver damage if taken in high doses. |
| Precautions | Do not use if you are taking other products that cause drowsiness, such as opioid pain relievers, alcohol, marijuana, or sleep drugs. Consult a doctor if you are pregnant or have liver problems. |
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What You'll Learn

Excedrin PM's effectiveness in treating headaches and sleeplessness
Excedrin PM is a medication that combines two pain relievers, acetaminophen and aspirin, with a sleep aid, diphenhydramine citrate. It is designed to provide temporary relief from occasional headaches, minor aches and pains, and accompanying sleeplessness. The acetaminophen in Excedrin PM helps to reduce fever and mild to moderate pain, while the aspirin inhibits pain-causing enzymes in the peripheral nervous system. Together, they provide effective pain relief. The diphenhydramine citrate, an antihistamine, acts as a sleep aid by causing drowsiness.
Excedrin PM is available in the form of caplets and is caffeine-free, ensuring that it does not keep individuals awake. It is a non-prescription medication that can be purchased conveniently. However, it is important to note that Excedrin PM is intended for adults and children aged 12 years and above. The recommended dosage is two caplets at bedtime, taken with a full glass of water.
The effectiveness of Excedrin PM in treating headaches and sleeplessness has been supported by customer reviews. Many customers have found it to be highly effective in relieving nighttime headaches and aiding sleep. Some have noted that it works faster than other products, taking about 20 minutes to take effect. However, it is important to be aware of potential side effects and use the medication sparingly. One of the active ingredients, diphenhydramine, is an anticholinergic, which may have potential long-term consequences for brain health.
Additionally, it is crucial to follow the recommended dosage and not exceed the daily limit of acetaminophen, as excessive consumption can lead to severe liver damage. Excedrin PM may also cause an allergic reaction, with symptoms such as a rash, itching, severe dizziness, or trouble breathing. If any of these symptoms occur, immediate medical attention is necessary. Furthermore, individuals taking other medications that cause drowsiness should exercise caution and consult their doctor or pharmacist before using Excedrin PM.
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The medication's ingredients and how they work
Excedrin PM is a medication that combines two pain relievers with a nighttime sleep aid. The active ingredients in Excedrin PM are acetaminophen, aspirin, and diphenhydramine citrate. These ingredients work together to provide temporary relief from pain associated with headaches, body aches, and muscle aches, along with accompanying sleeplessness.
Acetaminophen, like aspirin, inhibits enzymes in the body that produce prostaglandins, which are involved in pain sensations. However, acetaminophen appears to focus its pain-fighting effects on the central nervous system, allowing for increased pain tolerance and providing effective pain relief. Additionally, acetaminophen helps reduce fever and mild to moderate pain caused by conditions such as headaches, backaches, muscle strains, colds, or flu. It is important to note that acetaminophen may cause severe skin reactions and allergic reactions, and excessive consumption can lead to severe liver damage.
Aspirin, an NSAID (non-steroidal anti-inflammatory drug), also contributes to pain relief by inhibiting prostaglandins in the peripheral nervous system. However, it is essential to be cautious while using aspirin during pregnancy, as it may cause problems for the unborn child or complications during delivery.
Diphenhydramine citrate, the third ingredient, serves as the nighttime sleep aid in Excedrin PM. It is an antihistamine that can cause drowsiness, making it effective for aiding sleep. Antihistamines are also commonly used to relieve allergy or cold symptoms such as watery eyes, itchy eyes/nose/throat, runny nose, and sneezing. However, it is important to note that diphenhydramine is an anticholinergic, and research suggests that anticholinergics may have potential long-term impacts on brain health, including impeding memory formation.
Overall, Excedrin PM offers a triple action formula that addresses pain relief and sleeplessness, making it a convenient option for those seeking relief from nighttime headaches and sleep difficulties. However, it is always advisable to consult a healthcare professional before taking any medication to ensure its suitability and safety for your specific needs.
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Potential side effects and allergies
Excedrin PM is a medication that combines two pain relievers, acetaminophen and aspirin, with a sleep aid, diphenhydramine citrate. While Excedrin PM can be effective for pain relief and improving sleep, it's important to be aware of potential side effects and allergies.
Firstly, Excedrin PM can cause drowsiness due to its antihistamine component, diphenhydramine. This is the desired effect when taken at bedtime, but it can also cause daytime drowsiness if not tolerated well. Additionally, it may interfere with certain medical or lab tests, such as urine 5-HIAA and allergy skin tests, potentially leading to false results.
Secondly, Excedrin PM contains acetaminophen, which can cause severe skin reactions and, in rare cases, a serious allergic reaction. Symptoms of an allergic reaction include rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing. If any of these symptoms occur, immediate medical attention is required.
Furthermore, Excedrin PM contains aspirin, which may cause a severe allergic reaction in some individuals. Aspirin can also lead to severe stomach bleeding due to its non-steroidal anti-inflammatory (NSAID) properties. It is crucial not to use aspirin during pregnancy without medical advice, as it may negatively impact the unborn child or cause complications during delivery.
Excedrin PM also contains diphenhydramine, an anticholinergic, which has been associated with potential long-term consequences for brain health. Research suggests that anticholinergics may impede memory formation, and therefore, the long-term use of Excedrin PM could potentially impact brain function.
It is important to note that the effectiveness of Excedrin PM may diminish with repeated use, and cycling or sparing use may be necessary to maintain its efficacy. As with any medication, it is advisable to consult a healthcare professional before taking Excedrin PM to ensure it is safe and appropriate for your individual needs.
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Safety guidelines for adults and children
Excedrin PM is a medication that combines two pain relievers, acetaminophen and aspirin, with an antihistamine, diphenhydramine citrate, which acts as a sleep aid. This medication is intended to provide temporary relief from occasional headaches, minor aches and pains, and sleeplessness.
Adults:
- Excedrin PM is intended for adults experiencing occasional sleeplessness and is not recommended for long-term use.
- The recommended dosage for adults is two caplets at bedtime, taken with a full glass of water.
- Excedrin PM may interact with other medications or substances that cause drowsiness, including opioid pain relievers, alcohol, marijuana, sleep aids, muscle relaxants, and certain antihistamines. It is important to consult a doctor or pharmacist before taking Excedrin PM if you are currently taking any other medications or substances that may cause drowsiness.
- Excedrin PM contains acetaminophen, and adults should not exceed a total of 4000 milligrams (4 grams) of acetaminophen per day from all sources. It is important to ask your doctor or pharmacist how much acetaminophen is safe for you to take, as people with liver problems should take less.
- Excedrin PM may cause an allergic reaction in some individuals. Stop taking the medication and seek medical help immediately if you experience symptoms such as a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing.
- Excedrin PM contains aspirin, which may cause severe stomach bleeding. Do not take Excedrin PM if you are pregnant, especially after 20 weeks, unless specifically directed to do so by your doctor.
- Excedrin PM may interfere with certain medical or lab tests, such as urine 5-HIAA and allergy skin tests, potentially leading to false test results. Inform your healthcare providers if you are taking this medication.
Children:
- Excedrin PM is not recommended for children under 12 years of age.
- Children who have or are recovering from chickenpox or flu-like symptoms should not take Excedrin PM due to the risk of developing Reye's syndrome, a rare but serious illness.
- If a child is experiencing cold symptoms, do not give them Excedrin PM unless specifically directed to do so by a doctor.
- In the case of an overdose, seek immediate medical help or contact a Poison Control Center. Quick medical attention is critical for both adults and children, even if no symptoms are apparent.
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Where to buy Excedrin PM
Excedrin PM is available at several online and in-store retailers.
Amazon
Excedrin PM Headache Caplets are available on Amazon in a 24-count and a 100-count pack. Amazon offers free shipping on qualified orders.
CVS Pharmacy
CVS Pharmacy offers Excedrin PM Headache Pain Reliever/Nighttime Sleep-Aid Caplets. They offer free shipping on all eligible orders, as well as same-day delivery or free pickup.
Excedrin Website
The Excedrin website also offers Excedrin PM Headache relief medication.
It is important to note that Excedrin PM is a medication that contains acetaminophen and an antihistamine, which may cause drowsiness. This product is intended for the temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness. It is important to read the labels, warnings, and directions before using or consuming any medication, and to consult a doctor or pharmacist for more information about using the product safely.
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Frequently asked questions
Excedrin PM is a non-prescription medication that combines two pain relievers with a sleep aid. The sleep aid is a non-habit forming antihistamine, which can cause drowsiness and help with sleep. While generally safe for adults, it is important to be aware of potential side effects and interactions with other medications.
The active ingredients in Excedrin PM are acetaminophen, aspirin (NSAID), and diphenhydramine citrate. Acetaminophen may cause severe skin reactions and liver damage if overdosed. Aspirin may cause a severe allergic reaction and stomach bleeding. Diphenhydramine, an anticholinergic, may impede memory formation and negatively impact long-term brain health.
Excedrin PM is not suitable for children under 12 years old. It should also be avoided by those who are pregnant or have liver problems. If you are taking other medications that cause drowsiness, such as opioid pain relievers, sleep aids, or muscle relaxants, consult a doctor or pharmacist before using Excedrin PM.









































