
Diphenhydramine is an over-the-counter antihistamine medication that is recognised by the FDA as a safe and effective sleep aid for adults and children aged 12 and older. However, it is only recommended for occasional sleeplessness and for less than two weeks at a time. While diphenhydramine can be useful for short-term insomnia, it is not recommended for long-term use due to potential side effects such as dizziness, altered mental state, and urinary retention. Additionally, it may increase the risk for dementia and Alzheimer's disease if taken long-term. Instead, experts recommend alternative sleep aids like melatonin, good sleep hygiene, and cognitive behavioural therapy for the treatment of insomnia.
| Characteristics | Values |
|---|---|
| Safety | The FDA recognizes diphenhydramine as a safe and effective OTC sleep aid for adults and children aged 12 and older. |
| Usage | Diphenhydramine should only be used occasionally and for less than 2 weeks at a time. |
| Side effects | Diphenhydramine may cause dizziness, dry mouth, altered mental state, and urinary retention. It may also increase the risk of dementia and Alzheimer's disease if taken long-term. |
| Alternatives | Natural sleep aids such as melatonin or L-theanine, cognitive behavioral therapy, and prescribed sleep aids or antidepressants are recommended as alternatives. |
| Pregnancy | The FDA has not made a recommendation regarding the nightly use of diphenhydramine as a sleep aid during pregnancy. |
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What You'll Learn
- Diphenhydramine is recognised by the FDA as a safe sleep aid for adults and children over 12
- It should only be used occasionally and short-term
- Side effects include dizziness and an increased risk of dementia and Alzheimer's if used long-term
- It is not recommended for pregnant or nursing people
- Alternative treatments include CBT, melatonin, good sleep hygiene, and prescription sleep aids

Diphenhydramine is recognised by the FDA as a safe sleep aid for adults and children over 12
While many people use over-the-counter drugs to fall asleep faster, the use of medication to induce sleep in children or adults is generally not recommended. Diphenhydramine is an antihistamine medication that is recognised by the FDA as a safe sleep aid for adults and children over 12. It is available over the counter and is considered safe for occasional sleeplessness for up to two weeks at a time. However, it is not recommended for long-term use due to potential side effects.
Diphenhydramine is a common ingredient in allergy medications such as Benadryl and ZzzQuil. It is known to cause drowsiness as a side effect, which is why it is often used as a sleep aid. The recommended dosage for sleep is 50 mg taken orally 30 minutes before bedtime.
While diphenhydramine is recognised as safe for short-term use, it is important to be aware of potential side effects. These may include dizziness, dry mouth, urinary retention, and an altered mental state. In some cases, the use of diphenhydramine can lead to sleepwalking and other parasomnias. It is important to note that side effects may be more severe in older adults.
Instead of relying on medication, experts recommend improving sleep hygiene and making lifestyle adjustments to improve sleep. This includes maintaining a consistent sleep schedule, avoiding caffeine, alcohol, and large meals in the evening, and refraining from using electronic devices at least 30 minutes before bed. If insomnia is a chronic issue, it is advisable to consult a healthcare professional for guidance and potential prescription sleep aids or alternative treatments such as cognitive behavioural therapy (CBT).
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It should only be used occasionally and short-term
While diphenhydramine is recognised by the FDA as a safe and effective OTC sleep aid for adults and children aged 12 and older, it should only be used occasionally and short-term. This is because, while it may help with sleep in the short term, long-term use can lead to dependence and other side effects. For example, you may experience drowsiness the next day, or a "hangover" effect, making it difficult to get through work, school, and other daily activities.
Diphenhydramine is an antihistamine, and antihistamines are not recommended for regular use as a sleep aid. This is because, while they can help people fall asleep, they can also have side effects such as dizziness and an altered mental state. In addition, antihistamines can increase the risk of dementia and Alzheimer's disease if taken long-term. Instead, experts recommend alternative sleep aids like melatonin, good sleep hygiene, and cognitive behavioural therapy.
The American Academy of Sleep Medicine (AASM) does not recommend taking OTC antihistamines like diphenhydramine regularly for insomnia. This is because there is a lack of evidence to support their use for sleep in adults. In addition, people can build up a tolerance to diphenhydramine, meaning that it may stop helping with sleep over time. Therefore, it is recommended that diphenhydramine only be used occasionally and for short periods of time.
If you are experiencing chronic insomnia, it is important to talk to a healthcare professional. They may be able to recommend or prescribe other medications or treatments that are more suitable for long-term use. They may also be able to help you address any underlying medical issues that could be causing your insomnia, such as obstructive sleep apnea, depression, or circadian rhythm disorders.
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Side effects include dizziness and an increased risk of dementia and Alzheimer's if used long-term
Diphenhydramine is recognised by the FDA as a safe and effective OTC sleep aid for adults and children aged 12 and older. However, it is only recommended for occasional sleeplessness and for short periods of time (up to 2 weeks). Side effects of diphenhydramine include dizziness and an increased risk of dementia and Alzheimer's if used long-term.
Diphenhydramine is an antihistamine that blocks the effects of histamine in the body and can induce non-rapid eye movement sleep (NREM). Histamine levels in the brain decrease as one gets ready for sleep, and antihistamines like diphenhydramine mimic this natural function, causing drowsiness. While this can be a welcome side effect for those seeking a sleep aid, it is important to consider the potential risks associated with long-term use.
Dizziness is one of the most common side effects associated with diphenhydramine use. Additionally, long-term use of diphenhydramine and other antihistamines has been linked to an increased risk of dementia and Alzheimer's disease. This is especially true for older adults, as the side effects of antihistamines can be more dangerous in this population. Other side effects of antihistamines can include altered mental state, urinary retention, dry mouth, and parasomnias such as sleepwalking.
It is recommended that individuals suffering from long-term insomnia consult a physician or sleep specialist to address the problem, as it could be a result of underlying medical issues such as obstructive sleep apnea, depression, or circadian rhythm disorders. While diphenhydramine can be helpful for occasional sleeplessness, it is not recommended as a long-term solution due to the potential side effects and the risk of developing a tolerance. Alternative sleep aids such as melatonin, good sleep hygiene, and cognitive behavioural therapy are generally recommended as safer and more effective options for improving sleep quality.
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It is not recommended for pregnant or nursing people
While diphenhydramine is recognised by the FDA as a safe and effective OTC sleep aid for adults and children aged 12 and older, it is not recommended for pregnant or nursing people. This is because the FDA has not made a recommendation concerning the nightly use of a sleep aid in this population.
Diphenhydramine is an antihistamine, and antihistamines are known to cause drowsiness, which is often a welcome side effect for people taking them for colds or allergies. However, the use of medication to induce sleep is generally not recommended, especially for those who are pregnant or nursing.
The American Academy of Sleep Medicine (AASM) does not recommend taking OTC antihistamines like diphenhydramine regularly for insomnia. Instead, they recommend cognitive behavioural therapy (CBT) as a first-line treatment for insomnia. CBT focuses on sleep hygiene and strengthening the bed-sleep connection, helping to adjust the circadian rhythm and reduce anxiety about insomnia.
If you are experiencing insomnia, it is important to consult a healthcare professional. They may recommend prescribed sleep aids or antidepressants with a sedating effect. Chronic insomnia could be a symptom of underlying medical issues such as obstructive sleep apnea, depression, or circadian rhythm disorders.
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Alternative treatments include CBT, melatonin, good sleep hygiene, and prescription sleep aids
If you are experiencing insomnia or other sleep difficulties, there are several alternative treatments to consider other than diphenhydramine. Cognitive behavioural therapy (CBT) is one option, and this can help you address any negative thoughts or behaviours that may be impacting your sleep. Melatonin supplements are another popular choice, with around 3 million Americans using them in 2012. Melatonin is produced naturally in the body and helps to promote sleep, and supplements can be useful for those with insomnia or delayed sleep phase syndrome. However, it is important to note that melatonin supplements may not work for everyone and they should be used with caution, particularly if you have certain health conditions or are taking specific medications.
Good sleep hygiene practices can also be beneficial. This includes creating a comfortable and disruptive-free sleep environment, maintaining a consistent sleep schedule, and avoiding things like caffeine, nicotine, and evening alcohol consumption, which can interfere with sleep. Additionally, reserving an hour before bedtime for relaxing activities, such as reading or taking a warm bath, can help you wind down and prepare for sleep.
Prescription sleep aids are another alternative treatment option. These can be prescribed by a healthcare provider and may be considered if other treatments have not been effective. It is important to discuss your sleep difficulties with a healthcare professional to determine the best course of treatment for your specific needs.
Overall, while diphenhydramine may be effective for some people in the short term, there are a variety of alternative treatments for sleep difficulties that may be safer and more effective in the long term. These include CBT, melatonin supplements, good sleep hygiene practices, and prescription sleep aids.
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Frequently asked questions
Diphenhydramine is recognized by the FDA as a safe and effective OTC sleep aid for adults and children aged 12 and older. However, it should only be used occasionally and for less than 2 weeks at a time. Long-term use may increase the risk of dementia and Alzheimer's disease.
Side effects of diphenhydramine include drowsiness, dry mouth, altered mental state, and urinary retention. It can also lead to sleepwalking and other parasomnias.
Yes, there are alternative sleep aids such as melatonin, good sleep hygiene, and cognitive behavioral therapy (CBT). Rozerem (ramelteon) is also considered a safe medication to take long-term for insomnia.






















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