
Sleep is critical for good health, but many people struggle to get a good night's rest. There are many sleep aid products on the market, including prescription drugs, over-the-counter (OTC) medications, and dietary supplements. Two popular OTC sleep aids are Benadryl and Tylenol PM, which contain the antihistamine diphenhydramine, known for its sedative effects. While these medications can help with short-term sleep problems, they may not be the best long-term solution due to potential side effects and the risk of developing a tolerance. So, which is better for sleep, Benadryl or Tylenol PM?
| Characteristics | Values |
|---|---|
| Brand Name | Benadryl |
| Generic Name | Diphenhydramine |
| Side Effects | Drowsiness, altered mental state, urinary retention, dry mouth, sleepwalking, hyperactivity |
| Use Cases | Short-term treatment for insomnia, allergies, colds |
| Recommended Dosage | Allow 7-8 hours of sleep after taking |
| Long-term Benefits | None |
| Brand Name | Tylenol PM |
| Generic Name | Diphenhydramine |
| Side Effects | Linked to serious side effects with long-term use, increased risk of dementia |
| Use Cases | Short-term treatment for insomnia |
| Recommended Dosage | N/A |
| Long-term Benefits | N/A |
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What You'll Learn
- Benadryl and Tylenol PM are antihistamines that cause drowsiness
- Side effects of antihistamines include dry mouth, altered mental state, and urinary retention
- Long-term use of antihistamines may increase the risk of dementia
- Benadryl and Tylenol PM are not recommended for long-term insomnia treatment
- Alternatives to sleep aids include cognitive behavioural therapy and developing healthy sleep habits

Benadryl and Tylenol PM are antihistamines that cause drowsiness
Diphenhydramine is the main ingredient in many sleep aid products, including ZzzQuil and Advil PM, and it is also found in Tylenol PM. This ingredient belongs to a class of drugs called anticholinergics, which block the activity of acetylcholine, a brain chemical involved in muscle activation. By blocking this chemical, diphenhydramine slows down the nervous system, reducing breathing and heart rate, which can help people fall asleep.
While Benadryl and Tylenol PM can be effective in inducing sleep, they may not improve overall sleep quality. Additionally, regular use of these medications can lead to tolerance and dependence. Side effects of antihistamines include an altered mental state, urinary retention, and dry mouth. These side effects are usually mild but can pose risks, especially for elderly individuals.
It is important to note that the long-term use of OTC sleep aids like Benadryl and Tylenol PM has been linked to potential health risks. Studies have found that regular use of diphenhydramine, the active ingredient in these medications, may increase the risk of dementia. Therefore, while Benadryl and Tylenol PM can be helpful in the short term for falling asleep, they may not be the best long-term solution for improving sleep quality without potential side effects.
In conclusion, while Benadryl and Tylenol PM are antihistamines that can cause drowsiness and help with sleep, they should be used with caution and only as a short-term solution. It is always advisable to consult with a healthcare professional before taking any medication, including over-the-counter sleep aids, to ensure safe and appropriate use.
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Side effects of antihistamines include dry mouth, altered mental state, and urinary retention
While antihistamines like Benadryl and Tylenol PM can help people fall asleep, they also have side effects, including dry mouth, altered mental state, and urinary retention. Antihistamines are a class of drugs that treat allergies, and one of the side effects is sleepiness, so they are often used as short-term treatments for insomnia. However, they can have serious side effects if taken in larger-than-recommended doses.
Diphenhydramine, the active ingredient in Benadryl, is an antihistamine that is commonly sold under the brand name Benadryl and is also found in nighttime pain relief medications such as Advil PM or Tylenol PM. It is available in several forms, including tablets, capsules, powders, and liquids. While generally safe, diphenhydramine can cause serious side effects if taken in larger doses than recommended.
Doxylamine, another antihistamine, is sold under the brand name Unisom and is also found in combination with nighttime cold medicines like NyQuil. It also comes in liquid, capsule, and tablet form. Similar to diphenhydramine, it can cause sleepiness and is useful for short-term insomnia relief.
While antihistamines can help people fall asleep, they may not improve overall sleep quality. They can even have the opposite effect, causing hyperactivity, especially in children. Additionally, people can develop a tolerance to antihistamines very quickly, and they are not recommended for long-term use.
The side effects of antihistamines, such as dry mouth, altered mental state, and urinary retention, are generally mild and well-tolerated in young, healthy patients. However, they can pose a risk, especially for the elderly. Antihistamines can lead to sleepwalking and other parasomnias, and long-term use may increase the risk of dementia. Therefore, it is important to use these medications cautiously and only as directed.
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Long-term use of antihistamines may increase the risk of dementia
Both Benadryl and Tylenol PM are over-the-counter (OTC) sleep aids that contain the antihistamine diphenhydramine. Diphenhydramine is a first-generation antihistamine that is commonly used to treat allergies. While it is generally safe to use, it can cause serious side effects if taken in larger-than-recommended doses. One of the side effects of diphenhydramine is drowsiness, which is why it is often used as a short-term treatment for insomnia. However, it is important to note that antihistamines like Benadryl and Tylenol PM are not recommended for long-term use as sleep aids due to the risk of developing a tolerance and the potential for serious side effects.
The mechanism behind the potential link between antihistamine use and dementia is believed to involve the blocking of a brain chemical called acetylcholine. Diphenhydramine, as an anticholinergic drug, blocks the activity of acetylcholine, which plays a crucial role in muscle activation and cognitive function. By inhibiting acetylcholine, antihistamines can interfere with important brain processes, potentially leading to an increased risk of dementia over time.
While the potential side effects of long-term antihistamine use are concerning, it is important to note that not everyone who takes these medications will develop dementia. However, the risk is real and should be considered when deciding whether to use OTC sleep aids like Benadryl and Tylenol PM. It is always advisable to consult with a healthcare professional before starting any new medication, including OTC sleep aids. A doctor can help weigh the potential benefits and risks of different treatment options and recommend the most suitable approach for managing sleep issues or allergies.
Additionally, it is worth exploring non-drug treatments for sleep problems, such as cognitive behavioral therapy for insomnia (CBT-I) or developing healthy sleep habits. These approaches can often improve sleep quality without the need for medication and the associated risks. In some cases, a combination of non-drug treatments and medication may be recommended by a healthcare professional as part of a comprehensive plan to improve sleep over the long term.
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Benadryl and Tylenol PM are not recommended for long-term insomnia treatment
While Benadryl and Tylenol PM may help you fall asleep, they are not recommended for long-term insomnia treatment. Both medications are over-the-counter (OTC) antihistamines, which are primarily used to treat allergies. Antihistamines can cause drowsiness, which is often a welcome side effect for people with allergies. However, this side effect has led to the marketing of antihistamines as sleep aids.
Benadryl and Tylenol PM contain the active ingredient diphenhydramine, which is an anticholinergic drug. Anticholinergic drugs block the activity of acetylcholine, a brain chemical that plays a role in muscle activation. While diphenhydramine can help with falling asleep, it does not improve overall sleep quality. In fact, it can sometimes have the opposite effect, causing hyperactivity, especially in children. Additionally, the regular use of diphenhydramine has been linked to some serious side effects, including an increased risk of dementia.
The "hangover effect" of sleep aids like Benadryl and Tylenol PM can cause grogginess and affect your ability to drive or work for several hours after you wake up. These medications can also lead to parasomnias, such as sleepwalking, and other side effects like an altered mental state, urinary retention, and dry mouth. While these side effects are generally mild in young, healthy individuals, they can pose a risk to the elderly or those with other medical problems.
Furthermore, the long-term use of sleep aids may lead to the development of a tolerance, rendering them ineffective over time. Instead of relying solely on sleep aids, it is recommended to address the underlying causes of insomnia. This may involve seeking help from a physician or sleep disorders specialist to identify and treat any medical issues contributing to insomnia, such as obstructive sleep apnea, depression, or circadian rhythm disorders. Non-drug treatments, such as cognitive behavioural therapy for insomnia (CBT-I) or developing healthy sleep habits, can also be effective in improving sleep quality over the long term.
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Alternatives to sleep aids include cognitive behavioural therapy and developing healthy sleep habits
While Benadryl and Tylenol PM can be used as short-term treatments for insomnia due to their sedative effects, they are not recommended for long-term use. Antihistamines like Benadryl can cause side effects such as an altered mental state, urinary retention, and dry mouth. Additionally, they may lead to sleepwalking and other parasomnias, especially in children and the elderly.
Instead of relying on sleep aids with potential side effects, it is advisable to explore alternatives such as cognitive-behavioral therapy (CBT-I) and developing healthy sleep habits.
Cognitive-behavioral therapy for insomnia (CBT-I) is a structured and evidence-based approach that focuses on restructuring the thoughts, feelings, and behaviors contributing to insomnia. It includes cognitive interventions, behavioral interventions, and psychoeducational interventions. Cognitive restructuring aims to change unhelpful thoughts about sleep, while behavioral interventions involve stimulus control, sleep restriction, and incorporating relaxation techniques. Psychoeducation provides information about the connection between thoughts, feelings, behaviors, and sleep. CBT-I is considered effective for both short-term and chronic insomnia, and it can be provided by trained professionals or through digital applications.
Developing healthy sleep habits, also known as sleep hygiene, is another essential aspect of improving sleep quality. This includes establishing a regular sleep routine with fixed bedtimes and wake-up times, even on weekends. Creating a relaxing wind-down routine before bed and ensuring a quiet, dark, and cool sleep environment can also enhance sleep. Regular exercise, stress management through relaxation techniques, and a balanced diet with proper nutrition can further contribute to better sleep. Additionally, quitting smoking and limiting nicotine use before bed can positively impact sleep habits.
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Frequently asked questions
Benadryl and Tylenol PM are over-the-counter sleep aids that are commonly used to help with falling asleep and staying asleep. They are both antihistamines, which are a class of drugs that treat allergies. Antihistamines can cause sleepiness, so they are often used as short-term treatments for insomnia.
The side effects of Benadryl and Tylenol PM can include drowsiness, an altered mental state, urinary retention, and dry mouth. While these side effects are generally mild and well-tolerated in young, healthy patients, they can pose risks, especially for elderly individuals. Additionally, long-term use of these medications has been linked to an increased risk of dementia.
It is difficult to say which is better for sleep as it depends on individual factors and preferences. Both medications contain the same active ingredient, diphenhydramine, which is an antihistamine with sedative effects. It is recommended to consult a healthcare professional to determine which sleep aid is most suitable for your specific needs and circumstances.













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