
Sleep paralysis and wake-up strokes are two distinct conditions that can occur during sleep. Sleep paralysis is a common condition where an individual is conscious but unable to move or speak for a few seconds or minutes while falling asleep or upon waking up. It is often accompanied by hallucinations and a feeling of suffocation. On the other hand, a wake-up stroke is a stroke that occurs during sleep, with the time of onset unknown as the person wakes up with stroke symptoms. Wake-up strokes are not technically different from other strokes, but the delay in treatment due to unknown onset can make them more dangerous.
| Characteristics | Wake-Up Stroke | Sleep Paralysis |
|---|---|---|
| Definition | A stroke that occurs during sleep | A feeling of being conscious but unable to move, occurring when a person passes between stages of wakefulness and sleep |
| Symptoms | Signs include a droopy face, change in speech, loss of vision and coordination, and weakness or numbness on one side | Inability to move or speak, sensations of pressure or suffocation, hallucinations, daytime sleepiness |
| Treatment | Treated with thrombolytic medications called tPAs, which break up blood clots. However, the time of stroke onset is often unknown in wake-up strokes, which can delay treatment | No treatment available to stop an episode, but treatment is available to reduce the frequency of episodes. Cognitive behavioral therapy can help establish coping mechanisms |
| Risk Factors | High cholesterol, sleep disorders, smoking | Can run in families, more common among people with varying sleep schedules |
| Prevalence | 8-28% of strokes occur during sleep | Up to 4 out of 10 people may experience sleep paralysis |
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What You'll Learn
- Wake-up strokes occur during sleep, and symptoms are only noticed when the person wakes up
- Sleep paralysis occurs when a person passes between stages of sleep and wakefulness
- Wake-up strokes are not uncommon and account for approximately one in five acute ischemic strokes
- Sleep paralysis can be accompanied by hallucinations and a feeling of suffocation
- Wake-up strokes are more dangerous because treatment is delayed while the person is sleeping

Wake-up strokes occur during sleep, and symptoms are only noticed when the person wakes up
Wake-up strokes, also known as overnight strokes, occur when a person goes to bed feeling normal but wakes up with stroke symptoms. The time of stroke onset is unknown in these cases, which can delay emergency medical treatment and exclude survivors from typical stroke treatments. Studies show that wake-up strokes account for approximately one in five acute ischemic strokes, and they are not uncommon, with estimates of their incidence ranging from 8% in California to 39% in Ohio.
The signs and symptoms of a wake-up stroke are the same as those that occur during the day. However, these symptoms are not noticed until the person wakes up. For example, a person experiencing a wake-up stroke might find that they have vision loss when they open their eyes in the morning, or they might discover that their arm is too limp to remove the bed covers and sit up in bed. Other symptoms of a wake-up stroke include a droopy face, changes in speech, loss of coordination, and weakness or numbness on one side of the body.
The key difference between wake-up strokes and other types of strokes is the unknown time of onset, which presents a challenge for medical professionals. The treatment for acute stroke is fundamentally predicated on the time from symptom onset, and intravenous tissue plasminogen activator (tPA) is the only Food and Drug Administration (FDA)-approved nonsurgical reperfusion therapy for acute stroke. However, in the case of wake-up strokes, it is challenging to determine when the person had the stroke, and they might not be eligible for tPA treatment.
While wake-up strokes share similarities with sleep paralysis in that they both involve disruptions during sleep, they are distinct conditions. Sleep paralysis is a temporary condition where a person is conscious but unable to move or speak while falling asleep or upon waking up. It is often accompanied by hallucinations and a feeling of pressure or suffocation. Sleep paralysis is not a medical emergency and usually resolves on its own within a few seconds to a few minutes. In contrast, a wake-up stroke is a serious medical condition that requires immediate attention, and the person may experience more severe symptoms that persist upon waking.
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Sleep paralysis occurs when a person passes between stages of sleep and wakefulness
During sleep paralysis, a person is conscious but unable to move or speak. They may still be able to move their eyes and breathe, and may experience hallucinations, such as sensing a dangerous presence or feeling like their body is moving. Other symptoms include sensations of pressure or choking, and feelings of fear and anxiety. Sleep paralysis can be frightening, but it is not usually dangerous and is not a serious medical risk on its own. However, people who experience frequent or disturbing episodes may develop unhealthy sleep habits, which can lead to sleep deprivation and negative health effects.
Sleep paralysis can occur at any age, but it is more common among people with irregular sleep schedules, such as shift workers. Episodes are more frequent in a person's 20s and 30s. While the exact cause of sleep paralysis is not fully understood, it is believed to be caused by a disturbed REM cycle. It may be linked to stress and disrupted sleep schedules, and there may also be a genetic component.
Treatment for sleep paralysis depends on the underlying cause and can include medication, improving sleep hygiene, and addressing mental health issues. While there is no way to stop an episode once it starts, it may be possible to shorten it by focusing on making small body movements, such as wiggling a finger or toe.
Now, to address the initial query, a wake-up stroke is fundamentally different from sleep paralysis. A wake-up stroke is a stroke that occurs during sleep, and the person wakes up with stroke symptoms without knowing when they began. Wake-up strokes can be more dangerous than typical strokes because treatment is delayed while the person is asleep. On the other hand, sleep paralysis is a temporary condition where a person becomes paralysed while passing between sleep stages, often accompanied by hallucinations and anxiety. While it can be frightening, it is typically not harmful and does not require immediate medical attention.
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Wake-up strokes are not uncommon and account for approximately one in five acute ischemic strokes
A wake-up stroke is a stroke that occurs during sleep. People who experience overnight strokes will wake up with signs such as a droopy face, change in speech, loss of vision and coordination, and weakness or numbness on one side. As the time of stroke onset is unknown in these cases, wake-up strokes are often ineligible for treatment with reperfusion therapy with tissue-plasminogen activator (tPA). tPAs are thrombolytic medications that break up blood clots that block blood flow in the brain and are typically given within 4.5 hours of having an acute stroke.
The risk factors for ischemic and hemorrhagic strokes are similar and include high blood pressure, diabetes, and high blood cholesterol. Other risk factors are specific to the type of stroke. For example, blood clots can arise from coronary heart disease, atrial fibrillation, heart valve disease, and carotid artery disease. Carotid artery disease occurs when plaque builds up in the carotid arteries in the neck that supply blood to the brain, causing a common type of ischemic stroke. Smoking increases the risk of intracerebral hemorrhage, a type of stroke during sleep.
The role of sleep disorders in causing or increasing the risk of wake-up strokes is not well understood but is an active area of research. Obstructive sleep apnea and other sleep disorders are risk factors for stroke, and one study found that those who had wake-up strokes were more likely to snore than those who had strokes while awake. Sleep paralysis is a type of parasomnia where an individual is unable to move any part of their body right before falling asleep or as they wake up. It is unclear whether sleep paralysis is related to wake-up strokes.
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Sleep paralysis can be accompanied by hallucinations and a feeling of suffocation
Sleep paralysis is a condition where an individual is briefly unable to move or speak, either right before falling asleep or upon waking up. It occurs when the body is in between sleep and wakefulness, with the individual regaining awareness during the REM sleep stage. During a sleep paralysis episode, one remains conscious and aware of their surroundings but is unable to move or speak.
The exact cause of sleep paralysis is unknown, but it is linked to sleep disorders and certain mental health conditions. It is believed to be caused by a disturbed REM cycle, as it typically occurs when individuals are falling into or coming out of REM sleep. During the REM sleep stage, the brain usually paralyzes muscles to prevent individuals from acting out their dreams. However, during sleep paralysis, the mind is awake or half-awake, resulting in the awareness of being unable to move.
Sleep paralysis episodes can be frightening and impact an individual's quality of rest and daytime functioning. They are often associated with fear and negative emotions. While sleep paralysis itself is not dangerous, recurrent episodes may indicate an underlying sleep disorder such as narcolepsy. Improving sleep quality and maintaining a consistent sleep schedule can help reduce the occurrence of sleep paralysis.
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Wake-up strokes are more dangerous because treatment is delayed while the person is sleeping
Sleep paralysis is a common condition where a person feels conscious but is unable to move or speak for a few seconds or minutes when falling asleep or waking up. It occurs when a person's mind and body are out of sync during the transition between wakefulness and sleep. During sleep paralysis, a person may experience hallucinations and a feeling of suffocation, but it is not life-threatening and usually passes within a few minutes.
On the other hand, a wake-up stroke is a stroke that occurs during sleep, and the person wakes up with stroke symptoms such as a droopy face, change in speech, loss of vision, and weakness on one side of the body. Wake-up strokes are particularly dangerous because the time of stroke onset is unknown, and strokes require immediate treatment, ideally within a window of less than four and a half hours from the start of symptoms. The delay in treatment during a wake-up stroke can lead to poorer outcomes and exclude survivors from certain treatments, such as reperfusion therapy with tissue-plasminogen activator (tPA).
The signs and symptoms of a wake-up stroke are similar to those of strokes that occur during the day, but they are not noticed until the person wakes up. This delay in identifying the symptoms can impact the eligibility for specific treatments, as the time of stroke onset is a critical factor in determining the appropriate medical response.
Studies have suggested that wake-up strokes may be more severe at onset and could be the result of circadian changes in coagulability, serum catecholamine levels, and autonomic tone. The incidence of wake-up strokes varies across different regions, ranging from 8% in California to nearly 39% in Ohio.
In summary, wake-up strokes are more dangerous than sleep paralysis because the delay in treatment during sleep can impact the effectiveness of medical interventions. While sleep paralysis can be frightening, it is generally brief and resolves on its own, whereas a wake-up stroke requires prompt medical attention to improve the chances of a positive outcome.
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Frequently asked questions
A wake-up stroke is a stroke that occurs during sleep. The person goes to bed feeling normal but wakes up with symptoms of a stroke, such as a droopy face, change in speech, loss of vision and coordination, and weakness or numbness on one side.
Sleep paralysis is when you are conscious but unable to move or speak for a few seconds or minutes when falling asleep or waking up. It happens when your body is in between stages of sleep and wakefulness, typically during the REM stage.
No, a wake-up stroke is not the same as sleep paralysis. While both conditions involve disturbances during sleep, they are distinct from each other. A wake-up stroke is a type of stroke that occurs during sleep, with physical symptoms present upon waking. On the other hand, sleep paralysis is a temporary condition where an individual is conscious but unable to move or speak, typically lasting only a few seconds or minutes.











































