
Sleeping pills are drugs that can be used to treat insomnia, restless sleep, or difficulty falling asleep. They are available over the counter (OTC) or by prescription, with prescription pills being stronger. Sleeping pills can be short-acting or long-acting, and they can have various side effects, including constipation, muscle weakness, and drowsiness. They can also lead to dependency and addiction, so caution should be exercised when taking them. It is important to consult a doctor before starting any new sleep medication and to be aware of potential interactions with other substances.
| Characteristics | Values |
|---|---|
| Availability | Over-the-counter, natural supplements, or by prescription |
| Over-the-counter eligibility | Age 18 and older |
| Over-the-counter examples | Antihistamines, melatonin, valerian supplements |
| Prescription examples | Estazolam (Prosom), Zolpidem (Ambien), Eszopiclone (Lunesta), Zaleplon (Sonata), Doxepin (Silenor) |
| Dosage | 1-2 mg for insomnia treatment |
| Side effects | Constipation, diarrhea, muscle weakness, drowsiness, dizziness, balance problems, decreased sexual drive, weight gain, memory loss, hallucinations, mood changes |
| Long-term effects | Brain function impairment, change in sleep structure, dependency, drug tolerance |
| Withdrawal effects | Insomnia, anaphylactic reactions, CNS depression, worsening depression |
| Precautions | Check with a healthcare provider, do not take during pregnancy, do not take with other medications, alcohol, or vitamin supplements |
What You'll Learn

Prescription vs. over-the-counter sleeping pills
When considering taking sleeping pills, it is important to understand the differences between prescription and over-the-counter (OTC) medications. Prescription sleeping pills are stronger than OTC ones and require a prescription from a healthcare provider. These pills typically fall into three categories: hypnotics, barbiturates, and benzodiazepines. Hypnotics are a class of psychoactive drugs that induce sleep but come with potential side effects like headaches, nausea, and depression. Barbiturates are another type of prescription sleeping pill, but they are not commonly prescribed due to their high risk of dependence and overdose. Benzodiazepines, the third type, are effective for short-term use (less than four weeks) to treat insomnia. However, long-term use is not recommended due to the risk of serious side effects, including addiction and withdrawal symptoms.
On the other hand, OTC sleeping pills are available without a prescription and can be purchased in pharmacies and many other stores. They include antihistamine-containing sleep aids, which can be helpful if you have congestion and a cough. Melatonin supplements are also widely available OTC and can help regulate your sleep-wake cycle. While these OTC options are generally safe, they can still cause side effects such as daytime drowsiness, dry mouth, blurred vision, and constipation.
It is important to note that prescription medications are more likely to induce deep sleep but also carry a higher risk of dependence and side effects like sleepwalking. Natural remedies, such as valerian root or magnesium supplements, are not likely to be habit-forming, but their regulation as dietary supplements makes it challenging to know their exact contents.
When deciding between prescription and OTC sleeping pills, it is crucial to consult with a healthcare professional. They can recommend the best option based on your individual needs and circumstances, ensuring that you take the right medication safely and effectively.
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Short-term use only
Sleeping pills are typically a short-term solution for insomnia or sleep deprivation. They are available over the counter (OTC) or by prescription. While prescription pills are stronger, both types can cause side effects such as constipation, muscle weakness, and drowsiness the next day. Over-the-counter sleep aids often contain an antihistamine, which treats allergies but can also cause drowsiness. Prescription medications, on the other hand, include benzodiazepines, which stimulate the production of the brain chemical GABA, leading to sedation, muscle relaxation, and reduced anxiety.
Z-drugs, such as zolpidem (Ambien) and eszopiclone (Lunesta), are another type of prescription medication. They slow down brain activity, helping people fall asleep and stay asleep. However, they carry a risk of misuse and dependency, and patients may experience diminishing effects over time. Z-drugs can also cause complex sleep behaviours, such as sleepwalking or even driving while asleep.
Doctors may prescribe estazolam (Prosom) or zaleplon (Sonata) for short-term insomnia relief. Doxepin (Silenor) is another option, typically suggested for up to three months. Zolpidem is also available in a once-daily 12.5 mg extended-release form. When prescribing immediate-release zolpidem medications, doctors usually start with the lowest possible dose and gradually increase it if necessary.
Sleeping pills are generally not recommended for long-term use due to the risk of dependency and addiction. They should be used for the shortest time possible, ideally no more than one to three weeks. It is important to consult a doctor before taking any sleep medication, as they can interact with other substances and medications. Additionally, patients should gradually taper off sleeping pills to avoid negative withdrawal effects.
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Side effects
Sleeping pills can have a variety of side effects, and these vary by medication and individual. The most common side effects include drowsiness, dizziness, impaired focus, and difficulty with movement and balance. Some people may experience a "hangover effect" the day after taking sleeping pills, with symptoms such as muddled thinking, dizziness, and balance problems. These effects can negatively impact activities such as driving and operating machinery.
Sleeping pills can also cause digestive issues, including constipation, diarrhoea, gas, heartburn, and nausea. They may worsen snoring and sleep apnea. Prolonged use can lead to drug dependence, and when the medication is stopped, insomnia may return worse than before (rebound insomnia). Mixing sleeping pills with other sedatives or alcohol can lead to an overdose, and even death.
Older adults are more susceptible to side effects from sleeping pills, as the drugs can remain in their system longer. Side effects in this population include confusion, memory issues, and balance problems, which increase the risk of falls, hip fractures, and car accidents.
Sleeping pills can also cause allergic reactions and, in some cases, lead to drug dependence and abuse. Prolonged use can affect brain function, changing the structure of sleep and leading to dependency, drug tolerance, and other issues such as poor memory, brain degeneration, and an increased risk of Alzheimer's disease.
It is important to consult a doctor before taking sleeping pills, especially when considering long-term use, as they can have serious side effects and interactions with other medications.
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Dosage and forms
Sleeping pills are available in different forms and dosages, and they can be obtained over the counter or through a prescription. Over-the-counter sleep aids often contain antihistamines, which can cause drowsiness as a side effect. Common antihistamines used for sleep include diphenhydramine and doxylamine. Natural supplements such as melatonin and valerian are also available without a prescription and are known for their sleep-promoting properties.
Prescription sleeping pills, on the other hand, are typically stronger and may include medications such as estazolam (Prosom), zolpidem (Ambien), eszopiclone (Lunesta), and zaleplon (Sonata). These medications belong to a group known as Z-drugs, which act on the brain to induce sleep. The dosage of prescription sleeping pills can vary depending on the specific medication and the patient's needs. For example, eszopiclone (Lunesta) may be prescribed in 1 mg or 2 mg tablets, while zolpidem is available in a 12.5 mg extended-release form and up to 10 mg per day in immediate-release formulations.
Another prescription sleep medication is doxepin, sold under the brand name Silenor. It is available as an immediate-release tablet in 3 mg and 6 mg doses. Benzodiazepines are a powerful class of sleeping pills that includes medications like alprazolam, clonazepam, diazepam, and lorazepam. These drugs are available in short- and long-acting forms, and the dosage may vary depending on the patient's age, severity of symptoms, and other medical considerations.
Sleeping pills can also come in liquid form, either to be swallowed or administered via injection. It is important to note that the dosage and form of sleeping pills can vary depending on the patient's age, medical history, and the severity of their insomnia or sleep issues. Additionally, it is crucial to consult a healthcare provider before taking any sleep medication to ensure safe and appropriate use.
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Dependency and withdrawal
Sleeping pills can be highly addictive, and dependency can develop in as little as a few weeks. The longer one takes sleeping pills, the more the brain becomes dependent on them. The body becomes reliant on the drugs to function, and withdrawal symptoms can occur when one suddenly stops using them.
Withdrawal symptoms can be distressing and may include trouble sleeping (rebound insomnia), restlessness, anxiety, shivering, dizziness, sweating, tremors, and sleep disturbances. More severe symptoms can include hallucinations and seizures. These symptoms can emerge within hours to weeks after discontinuing the medication and may persist for several weeks.
To prevent dependence, sleeping pills should be used as directed and for the shortest duration possible. If one is experiencing adverse effects, it is vital to consult a doctor to prevent the escalation to physical or emotional dependence.
The best way to stop taking sleeping pills is to gradually reduce the dose with a doctor's guidance. Psychological or therapeutic support can aid in this process. Medical detox and medications can help manage withdrawal symptoms, while cognitive behavioral therapy can address the psychological aspects of dependence.
It is important to note that not everyone who becomes dependent on sleeping pills develops an addiction, although it is a risk factor. However, those with an addiction to sleeping pills may need to enter a detoxification or rehabilitation program to safely manage their withdrawal symptoms.
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Frequently asked questions
Some common over-the-counter sleeping pills include antihistamines, melatonin, and valerian supplements. Antihistamines like diphenhydramine and doxylamine can cause drowsiness as a side effect. Melatonin is a hormone that promotes sleep, and valerian is an herb that aids relaxation and sleep.
Prescription sleeping pills include estazolam (Prosom), zolpidem (Ambien), eszopiclone (Lunesta), and zaleplon (Sonata). These are often referred to as Z-drugs and are typically prescribed for short-term relief of insomnia. Benzodiazepines (benzos) are another class of prescription sleeping pills that include drugs like alprazolam, clonazepam, diazepam, and lorazepam.
Sleeping pills can cause various side effects, including constipation, muscle weakness, dizziness, and balance problems. They can also lead to dependency and addiction, especially with long-term use. Additionally, there may be risks associated with taking these medications during pregnancy or while breastfeeding. It is important to consult a healthcare provider before taking any sleeping medication to ensure safe and proper usage.

