
Sleeping pills are a common treatment for insomnia, a condition that affects people's ability to fall asleep or stay asleep. While they can be effective, there are concerns about their long-term use, side effects, and potential risks, including an increased risk of cancer and mortality. Several studies have investigated the link between sleeping pills and cancer, with some suggesting a potential association, particularly with cancers of the respiratory system, such as lung cancer. However, the findings are mixed, and more research is needed to establish causation and understand the underlying mechanisms. As a result, healthcare providers generally recommend exploring alternative treatments for sleep issues before resorting to sleeping pills.
| Characteristics | Values |
|---|---|
| Risk of lung cancer | Studies suggest that patients who took over 132 sleeping pills per year were 35% more likely to be diagnosed with lung cancer. |
| Risk of death | Studies suggest that patients who took over 132 sleeping pills per year were five times more likely to die within the next 2.5 years. |
| Cancer types | Studies suggest an increased risk of oral cancer, kidney cancer, esophageal cancer, breast cancer, liver cancer, bladder cancer, lymphoma, colon cancer, and prostate cancer. |
| Cancer incidence | A 2015 study found a link between sleep medication use and an increased incidence of cancer, especially in the respiratory system. |
| Cancer risk factors | The quantity and duration of sleep medication use were associated with an increased risk of cancer. |
| Alternative treatments | Healthcare providers recommend trying other methods such as improving the sleeping environment, cognitive behavioral therapy (CBT), and nondrug treatments before resorting to sleeping pills. |
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What You'll Learn

Sleeping pills and lung cancer risk
Several studies have found a link between the use of sleeping pills and an increased risk of developing cancer. However, it is important to note that the research in this area is still evolving, and more studies are needed to establish a direct causal relationship.
One study, published in BMJ Open in 2019, found that people who took prescription sleep aids were 35% more likely to be diagnosed with cancer during the study period compared to those who did not take sleeping pills. This risk increased with the number of pills prescribed, with those taking over 132 pills per year having a 35% greater risk of developing cancer than those with fewer prescriptions. The study also found that the use of sedative medications was a better predictor of lung cancer development than a person's smoking habit.
Another study, involving 29,441 participants, found a 16-18% increased risk of being diagnosed with any cancer among those who used sleep medications compared to non-users. Site-specific analyses showed a more pronounced association between the quantity and duration of sleep-medication use and subsequent cancer of the respiratory system. Those who used more than 100 defined daily doses per year had a 3.47 times greater risk of developing respiratory cancer compared to non-users.
A 2012 study of 15,000 Taiwanese patients taking Ambien found that they were 68% more likely to develop any cancer, with the risk being more than double for oral cancer, followed by kidney, oesophageal, breast, lung, liver, and bladder cancer. Men were found to be at higher risk than women. Similarly, a 2018 meta-analysis of six studies involving over 200,000 Europeans and Koreans taking sedatives found an increased likelihood of being diagnosed with oesophageal, kidney, prostate, liver, stomach, and pancreatic cancers.
While the research suggests an association between sleeping pill use and an increased risk of cancer, it is important to consult a healthcare professional before starting or stopping any medication. Sleeping pills can be beneficial for those with insomnia or sleep disorders, but they are typically recommended as a short-term solution, as long-term use may carry risks that outweigh the benefits. Healthcare providers often suggest trying alternative methods to improve sleep before resorting to sleeping pills, such as cognitive behavioural therapy (CBT) or changes to the sleeping environment.
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Sleeping pills and increased mortality
Several studies have found a link between the use of sleeping pills and an increased risk of mortality. One study, which tracked 10,531 patients prescribed hypnotic sedatives, found that those who were the heaviest users of prescription sleep aids were 35% more likely to be diagnosed with cancer during the study period. The use of sedative medications was a better predictor of cancer development than a participant's smoking habit.
Another study, which included 6 studies of more than 200,000 Europeans and Koreans taking sedatives, found that those prescribed sedatives were more likely to be diagnosed with esophageal, kidney, prostate, liver, stomach, and pancreatic cancers. The risk of death was also found to be five times greater for those taking more than 132 pills per year compared to those taking no sleep aids.
A 2015 study found that sleep-medication use was associated with an increased incidence of cancer of the respiratory system. The study showed that the use of >100 defined daily doses per year was associated with a 3.47 odds ratio of developing cancer of the respiratory system, indicating a more pronounced association between the quantity and duration of sleep-medication use and respiratory cancer.
While the exact mechanism for the increased risk of mortality among sleeping pill users is not fully understood, the studies suggest that the long-term risks of taking sleep aids may outweigh the benefits. Healthcare providers generally recommend trying other methods to improve sleep before resorting to sleeping pills. These can include changing one's sleeping environment, cognitive behavioral therapy (CBT), or improving sleep hygiene.
It is important to note that the studies on the link between sleeping pills and increased mortality have some limitations. For example, they may not establish a causal relationship between sleep drugs and increased mortality, and further research is needed to examine the potential carcinogenic mechanisms associated with hypnotic medications. Additionally, large population-based studies are lacking, and the findings from existing studies are mixed.
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Sleeping pills: side effects
While sleeping pills can be effective in treating insomnia and promoting sleep, they can also have several side effects and are associated with an increased risk of cancer and death.
A 2018 study found that people who take sleeping pills are at a greater risk of dying or developing cancer within the next two and a half years. The study also revealed that heavy users of sleeping pills (over 132 pills prescribed per year) had a 35% higher risk of cancer than those with fewer pills prescribed. The risk of death was five times greater for those who took more than 132 pills per year compared to those who did not take any sleep aids. Another study published in BMJ Open also found a modest but statistically significant increase in cancer incidence among those taking sleep medications.
Sleeping pills can cause a range of side effects, including constipation, diarrhea, muscle weakness, digestive problems, and daytime drowsiness. Approximately 8 out of 10 people experience a hangover effect the day after taking sleep medicine, with symptoms such as drowsiness, muddled thinking, dizziness, and balance problems. These side effects can negatively impact daily activities such as driving, working, and completing tasks requiring full attention.
Sleeping pills can also cause parasomnias, which are complex sleep behaviors where individuals may sleepwalk, eat, make phone calls, or even drive while asleep. While parasomnias are rare, they are difficult to detect once the medication takes effect and can lead to dangerous situations.
Older adults are more susceptible to the side effects of sleeping pills, with an increased risk of confusion, memory problems, and falls. Pregnant or breastfeeding women are advised against taking sleeping pills, and individuals with certain chronic lung problems, such as asthma or COPD, should exercise caution as sleeping pills can interfere with normal breathing.
It is important to note that sleeping pills are generally recommended for short-term use, as long-term use can lead to dependence and other problems. If you are considering taking sleeping pills, it is advisable to consult a healthcare professional to weigh the benefits against the potential side effects and explore alternative treatments.
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Sleeping pills: long-term use
Sleeping pills are used to treat insomnia by making people feel drowsy and relaxed. However, they are not recommended for long-term use due to various side effects and risks.
Firstly, sleeping pills can cause side effects such as daytime drowsiness, confusion, and parasomnia, or sleepwalking. In addition, long-term use of sleeping pills often comes with risks that outweigh the benefits of improved sleep. For instance, a 2018 study found that people who take sleeping pills are more likely to die or develop cancer within the next two and a half years. Another study of 15,000 Taiwanese patients taking Ambien found that they were 68% more likely to develop any cancer, with the risk being more than double for oral cancer. The risk was also significantly increased for kidney, esophageal, breast, liver, lung, and bladder cancer. Furthermore, a Finnish study found that the use of sleep medications was associated with an increased incidence of cancer, particularly in the respiratory system. Similarly, a study by the British medical publication BMJ Open found that the heaviest users of prescription sleep aids were 35% more likely to be diagnosed with cancer during the study period.
Due to these potential risks, healthcare providers recommend trying other methods to improve sleep before resorting to sleeping pills. For example, changing the sleeping environment or cognitive behavioral therapy (CBT) are often suggested as alternative treatments for insomnia. In addition, older adults and pregnant or breastfeeding individuals are generally advised to avoid sleeping pills due to special risks associated with these populations.
While melatonin supplements are generally regarded as safe, data on their long-term use is scarce, and they may interact with other medications. Therefore, it is recommended to consult a healthcare professional before taking melatonin or any other sleep aid.
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Sleeping pills: alternatives
Several studies have found a link between the use of sleeping pills and an increased risk of developing cancer, including lung cancer. For instance, a 2012 study of 15,000 Taiwanese patients taking Ambien found that they were 68% more likely to develop any type of cancer, with the risk being more than double for oral cancer, followed by kidney, oesophageal, lung, breast, liver, and bladder cancer. Men were found to be at higher risk than women.
Another study, which involved 10,531 patients prescribed hypnotic sedatives, found that those who took the most pills (over 132 pills per year) had a 35% greater risk of being diagnosed with cancer than those who took fewer pills. This study also found that the use of sedatives was a better predictor of cancer development than a patient's smoking habit.
Given the potential risks associated with sleeping pills, it is worth considering some alternative options for improving sleep. Here are some suggestions:
- Melatonin supplements: Melatonin is a hormone that is naturally released in the brain about four hours before we feel sleepy. It is triggered by the body's response to reduced light exposure, which should occur naturally at night. However, exposure to artificial light from sources such as phones, laptops, or TVs can prevent the release of melatonin, making it difficult to fall asleep. Melatonin supplements are available over the counter and can help regulate your sleep schedule, especially when travelling across time zones. However, it is important to note that melatonin supplements are not regulated by the FDA, so dosages and ingredients may vary between manufacturers. It is recommended to stick to one brand and avoid purchasing from unknown sources.
- Warm milk, chamomile tea, and tart cherry juice: While there is not much scientific proof that these drinks work, they are worth trying for those seeking a treatment without side effects or drug interactions. Warm milk is believed to contain chemicals that simulate the effects of tryptophan in the brain, which is a building block for serotonin, involved in the sleep-wake transition. Chamomile tea is thought to contain flavonoids that may interact with benzodiazepine receptors in the brain, also involved in the sleep-wake transition.
- Valerian root: Valerian is an herbal plant whose dried root can be made into pills, teas, or other formulas meant to improve sleep. Research findings are mixed, but some evidence suggests that valerian can help people fall asleep faster and sleep more soundly.
- Lavender essential oil: Lavender essential oil is available in various products such as lotions, bath salts, and sheet sprays. While there may not be a well-established physiological effect on the sleep system, the psychological effect of helping people relax and unwind can indirectly improve sleep.
- Herbal tea: Teas meant for bedtime usually contain herbal blends such as passionflower, chamomile, and sometimes valerian.
- Antihistamine medications: Medications containing the active ingredient diphenhydramine, such as Benadryl, are commonly used as sleep aids. They work by blocking the body's histamine response, which includes alertness, leading to drowsiness. However, it is important to start with the lowest possible dose and use them with caution, as regular use can lead to a rebound effect and insomnia when stopping.
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Frequently asked questions
Studies have shown a link between taking sleeping pills and an increased risk of developing cancer, including lung cancer. However, it is not yet clear whether sleep drugs are the cause of the increased cancer risk or if those at a higher risk of developing cancer are simply more likely to seek a prescription for sleep problems.
Sleeping pills have been linked to oral cancer, kidney cancer, esophageal cancer, breast cancer, liver cancer, lung cancer, bladder cancer, colon cancer, prostate cancer, and lymphoma.
The risk of developing cancer increases by 68% for those taking sleeping pills, with the risk being higher for those taking a higher dose. Heavy users of sleeping pills (over 132 pills prescribed per year) had a 35% greater risk of developing cancer than those with fewer pills prescribed.
Sleeping pills can have side effects, so they are not recommended for long-term use. Most healthcare providers suggest trying other methods to improve your sleep before taking sleeping pills.
Alternatives to sleeping pills include changing your sleeping environment, cognitive behavioral therapy (CBT), and improving your sleep hygiene.






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