
Naltrexone is a medication used to treat opioid and alcohol use disorders. It blocks the euphoric and rewarding feelings associated with opioid drugs and alcohol, helping to reduce cravings and maintain sobriety. While naltrexone is an effective treatment option, it can cause side effects such as dizziness, drowsiness, sedation, and sleep problems (insomnia) in a small percentage of people. As a result, it is important to consider the potential interactions and side effects of combining naltrexone with sleeping pills. It is always recommended to consult a healthcare professional before taking any medication, including sleeping pills, concurrently with naltrexone to ensure safe and effective use.
| Characteristics | Values |
|---|---|
| Should you take sleeping pills while on naltrexone? | No information found. However, naltrexone may cause insomnia in about 3% of people. |
| Naltrexone side effects | Dizziness, drowsiness, sedation, fainting, nausea, vomiting, loss of appetite, joint pain, muscle cramps, headache, tooth pain, cold symptoms, anxiety, nervousness, depression, agitation, irritability, abnormal behaviour, suicidal thoughts, increased energy, reckless behaviour, trouble sleeping. |
| Naltrexone and opioids | Naltrexone blocks the effects of opioids. Do not take opioids while on naltrexone, as it can lead to overdose and death. |
| Naltrexone and alcohol | Naltrexone blocks the feelings of intoxication from alcohol. Do not use naltrexone to drive or perform activities under the influence of alcohol. |
| Naltrexone and other medications | Tell your healthcare provider about all medications, vitamins, minerals, herbal products and supplements you are taking. |
| Naltrexone and pregnancy | Consult your healthcare provider if you are pregnant, trying to get pregnant or breastfeeding. |
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What You'll Learn

Naltrexone may cause insomnia in 3% of patients
Naltrexone is a medication used to treat opioid use disorder (OUD) and alcohol use disorder (AUD). It is available in pill form or as an extended-release intramuscular injectable. The pill form is typically taken once a day, while the injectable form is administered once a month by a practitioner.
Naltrexone can also cause digestive side effects such as nausea, constipation, and diarrhea. It may also lead to opioid withdrawal symptoms such as anxiety, sleeplessness, yawning, fever, sweating, and nausea. Patients should be opioid-free for a minimum of 7 to 14 days before starting naltrexone treatment to avoid sudden withdrawal.
While naltrexone can cause insomnia in some patients, it is important to consult a doctor before taking any sleeping pills or other medications in conjunction with naltrexone. Naltrexone patients should not use any other opioids, illicit drugs, alcohol, or sedatives. They should notify their practitioner of all medications they are currently taking and any changes in their medication.
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Naltrexone can cause drowsiness, sedation, dizziness and fatigue
Naltrexone is a medication approved by the Food and Drug Administration (FDA) to treat opioid use disorder (OUD) and alcohol use disorder (AUD). It is not a cure for addiction but helps patients with OUD to stay drug-free and maintain their recovery. Naltrexone also helps to reduce alcohol cravings and the amount of alcohol consumed, aiding patients in maintaining their sobriety.
Naltrexone can cause drowsiness, sedation, dizziness, and fatigue. These are all possible side effects of naltrexone treatment. Patients taking naltrexone should refrain from driving, operating heavy machinery, or performing other hazardous activities until they know how the medication affects them. In addition, naltrexone may cause some patients to feel depressed or experience suicidal thoughts and tendencies. It is important to inform your doctor if you have a history of mental health issues before starting naltrexone treatment. Family members or close contacts should also be made aware so they can monitor for any mood changes and seek medical help if necessary.
Naltrexone can also cause insomnia, nervousness, and anxiety in some patients. If you experience these side effects, consult your doctor to determine if adjusting the time of day you take your medication may be beneficial. It is worth noting that naltrexone may also cause withdrawal symptoms in individuals who are physically dependent on opioids. Therefore, it is crucial to be opioid-free for a minimum of 7 to 14 days before initiating naltrexone therapy to avoid sudden withdrawal.
While naltrexone can cause drowsiness, sedation, dizziness, and fatigue, it is important to consult your doctor or healthcare provider before taking any additional medications, including sleeping pills. They can advise you on potential drug interactions and adjust your treatment plan accordingly.
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Naltrexone may cause depression and suicidal thoughts
Naltrexone is a medication used to treat opioid use and alcohol use disorders in adults. It is part of a comprehensive management program that includes counselling and other behavioural health therapies. While naltrexone is an effective treatment for many people, it may cause some patients to feel depressed and have suicidal thoughts.
There is some conflicting evidence regarding the link between naltrexone and depression. One early report linked naltrexone with depression after a study of volunteers with no history of opioid or other drug use. The study found that a single 50-mg dose of naltrexone led to a range of unpleasant symptoms, including dysphoria. However, other studies have found no significant link between naltrexone and depression.
Despite the conflicting evidence, it is important to be aware of the potential side effects of naltrexone. Patients taking naltrexone should be monitored for the development of depression and suicidality. Family members and caregivers should also be made aware of these potential side effects and should seek medical attention if the patient exhibits any symptoms of depression. Other common side effects of naltrexone include dizziness, drowsiness, sedation, fainting, insomnia, nervousness, anxiety, and fatigue.
If you are experiencing any side effects from naltrexone, it is important to speak with your doctor. Do not stop taking the medication or change your dose without consulting your healthcare provider. Your doctor may recommend adjusting the time of day you take your medication or exploring alternative treatments. It is important to follow your doctor's instructions and continue taking naltrexone as directed to ensure the success of your treatment.
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Naltrexone is not recommended for pregnant or breastfeeding women
Naltrexone is a medication used to treat alcohol use disorder (AUD) and opioid use disorder (OUD). It is not recommended for pregnant or breastfeeding women due to potential risks to the fetus and infant.
Firstly, naltrexone is classified as a pregnancy risk category C drug by the Federal Drug Administration (FDA). This classification means that animal studies have shown adverse effects on the fetus, but there is limited research on human subjects to confirm these findings. Therefore, pregnant women are generally advised to avoid using naltrexone unless the benefits of the medication outweigh the risks to the fetus.
Secondly, naltrexone may cause withdrawal symptoms in individuals who are physically dependent on opioids. These withdrawal symptoms, such as heart palpitations and loss of appetite, could negatively affect a pregnant woman's health and the developing fetus. Additionally, there is a high risk of relapse during the opioid-free period before starting naltrexone treatment, which could further impact the pregnancy.
Thirdly, naltrexone has been known to cause insomnia in approximately 3% of patients. It has also been associated with nervousness and anxiety, which could potentially impact the well-being of pregnant women. Dizziness, drowsiness, sedation, and fainting are also possible side effects, and pregnant women should refrain from activities that could be dangerous until they know how naltrexone affects them.
Finally, there is limited research on the use of naltrexone during breastfeeding. While it is excreted into human milk, the potential risks to the infant are not fully understood. Therefore, breastfeeding women should consult with their healthcare provider to weigh the benefits of the medication against the potential risks to the infant.
In summary, while naltrexone may be an option for pregnant women struggling with AUD or OUD, it is not recommended due to the potential risks to the fetus and infant. Pregnant and breastfeeding women should always consult with their healthcare team before taking any medication, including naltrexone, to ensure the benefits outweigh the risks.
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Naltrexone is not a treatment for opioid withdrawal
Naltrexone is a medication approved by the Food and Drug Administration (FDA) to treat opioid use disorder (OUD) and alcohol use disorder (AUD). It is not a cure for addiction, but rather a component of a comprehensive treatment plan, which includes counselling and other behavioural health therapies.
If a patient relapses after a period of opioid abstinence, or stops naltrexone treatment, the dosage of opioids they previously used may have serious consequences, including respiratory arrest, circulatory collapse, and death. This is because naltrexone increases sensitivity to opioids, and patients' tolerance may be reduced.
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Frequently asked questions
It is not advisable to take sleeping pills while on naltrexone without first consulting a doctor. Naltrexone is known to cause drowsiness and dizziness in some patients, and taking sleeping pills concurrently could potentially amplify these side effects.
Common side effects of naltrexone include nausea, vomiting, loss of appetite, joint pain, muscle cramps, headache, dizziness, drowsiness, insomnia, tooth pain, anxiety, nervousness, and cold symptoms. Naltrexone may also cause patients to feel depressed or display abnormal behaviours, including agitation, irritability, and suicidal thoughts.
If you experience any side effects from taking naltrexone, it is important to consult your doctor or healthcare provider immediately. They may advise you to adjust your dosage or provide alternative treatment options.
Naltrexone should not be taken with opioids, sedatives, tranquilizers, or other drugs. It is important to disclose all medications, vitamins, and supplements you are currently taking to your doctor before starting naltrexone treatment.








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