
Antihistamines are commonly used to treat allergies, but they can also cause drowsiness. This side effect has led people to use antihistamines as a sleep aid. However, experts advise against this practice due to the risk of long-term side effects, including altered mental state, urinary retention, and dry mouth. Additionally, antihistamines may cause hyperactivity in children and increase the risk of dementia and Alzheimer's disease in older adults. Sleeping pills, which are available over the counter or by prescription, also carry risks and should not be used long-term. Instead of relying on antihistamines or sleeping pills, individuals with insomnia should consider alternative treatments such as cognitive behavioural therapy, sleep hygiene, and natural remedies like melatonin or valerian supplements.
Can you take antihistamine with sleeping pills?
| Characteristics | Values |
|---|---|
| Antihistamines cause drowsiness | Yes, antihistamines such as Benadryl, diphenhydramine, and doxylamine succinate can cause drowsiness. |
| Antihistamines as sleep aids | Some people use antihistamines to help with insomnia or as a sleep aid. However, it is not recommended for long-term use due to potential side effects and limited research on their effectiveness. |
| Alternatives to antihistamines for sleep | Recommended alternatives include melatonin, good sleep hygiene, cognitive behavioral therapy (CBT), and natural remedies like valerian supplements. |
| Antihistamines and pregnancy | The FDA has found Benadryl safe for allergies during pregnancy, but there is no recommendation for its nightly use as a sleep aid. First-generation antihistamines should be used sparingly or avoided during pregnancy and nursing. |
| Over-the-counter (OTC) availability | Antihistamines and some sleeping pills are available OTC, but it is advised to consult a healthcare provider before use, especially during pregnancy or for children. |
| Side effects of antihistamines | Potential side effects of antihistamines include altered mental state, urinary retention, dry mouth, sleepwalking, and other parasomnias. Long-term use may increase the risk of dementia and Alzheimer's disease. |
| Side effects of sleeping pills | Sleeping pills can have side effects and are not recommended for long-term use, especially for older adults as there may be safer alternatives. |
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What You'll Learn
- Antihistamines are not recommended for long-term use as a sleep aid due to potential side effects
- Antihistamines can cause drowsiness, but they may not improve overall sleep quality
- Some over-the-counter sleep aids are simply repackaged antihistamines
- Antihistamines are not recommended for pregnant or nursing women as sleep aids
- Anticholinergic antihistamines may increase the risk of dementia and Alzheimer's disease

Antihistamines are not recommended for long-term use as a sleep aid due to potential side effects
Antihistamines are not recommended for long-term use as a sleep aid due to their potential side effects. While antihistamines can make people drowsy, there is little research to support their effectiveness as a sleep aid. They are also associated with several side effects, including altered mental state, urinary retention, and dry mouth, as well as sleepwalking and other parasomnias. Furthermore, antihistamines can cause hyperactivity in children and may lead to the development of tolerance with long-term use.
Additionally, there are concerns about the potential impact of long-term antihistamine use on cognitive function. Anticholinergic antihistamines, such as diphenhydramine and doxylamine succinate, have been linked to an increased risk of dementia and Alzheimer's disease. These medications can produce cognitive impairment by inhibiting acetylcholine, a neurotransmitter essential for brain functions such as short-term memory and thinking.
For these reasons, it is generally recommended to avoid using antihistamines as a long-term sleep aid, especially in older adults and during pregnancy or breastfeeding. Instead, experts suggest alternative treatments for insomnia, such as cognitive behavioral therapy (CBT), which focuses on sleep hygiene and adjusting circadian rhythms. Other recommendations include maintaining a consistent sleep schedule, avoiding alcohol, caffeine, and large meals in the evening, and refraining from using electronic devices before bed.
If you are experiencing chronic insomnia, it is advisable to consult a healthcare professional for guidance and potential prescription options. They can help address any underlying medical issues that may be contributing to sleep difficulties and provide safer alternatives to antihistamines for long-term use.
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Antihistamines can cause drowsiness, but they may not improve overall sleep quality
Antihistamines are commonly used to treat allergies, but they can also cause drowsiness as a side effect. While this may be a welcome effect for those seeking relief from allergies or a cold, using antihistamines as a sleep aid is not recommended.
Antihistamines, such as diphenhydramine and doxylamine succinate, can cross the blood-brain barrier and mimic the natural decrease in histamine levels that occurs as the body prepares for sleep, thus inducing drowsiness. However, while antihistamines may help you fall asleep initially, they may not improve overall sleep quality. In some cases, they can even have the opposite effect, causing hyperactivity, especially in children.
Additionally, long-term use of antihistamines may lead to harmful side effects, such as altered mental state, urinary retention, and dry mouth, as well as sleepwalking. These side effects can be dangerous, especially for older adults. Moreover, antihistamines may increase the risk for dementia and Alzheimer's disease. Furthermore, many people develop a tolerance to antihistamines, rendering them ineffective as a long-term solution for insomnia.
Instead of relying on antihistamines for sleep, it is recommended to practice good sleep hygiene, which includes maintaining a consistent sleep schedule, avoiding caffeine and alcohol in the evenings, and refraining from electronic device use before bed. For those struggling with chronic insomnia, cognitive behavioral therapy (CBT) is often suggested as a first-line treatment, as it can help adjust circadian rhythm and reduce anxiety related to sleep difficulties. If insomnia persists, it is advisable to consult a healthcare professional, who can recommend or prescribe alternative treatments or medications.
In conclusion, while antihistamines can induce drowsiness, they are not a recommended solution for improving sleep quality due to their potential side effects, limited effectiveness, and lack of long-term benefit. It is always advisable to consult a healthcare provider before taking any over-the-counter sleep aids or supplements to ensure safe and effective use.
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Some over-the-counter sleep aids are simply repackaged antihistamines
While antihistamines can make you feel drowsy, they are not recommended as a sleep aid. Side effects can include an altered mental state, urinary retention, and dry mouth. In addition, long-term use may lead to harmful side effects and an increased risk of dementia and Alzheimer's disease. Antihistamines can also cause hyperactivity in children and lead to sleepwalking and other parasomnias.
Despite this, many people use antihistamines as a sleep aid, and some over-the-counter sleep aids are simply repackaged antihistamines. Diphenhydramine and doxylamine succinate are sedating antihistamines that are found in a wide range of non-prescription sleep and allergy medicines. They work by decreasing histamine levels in the brain, which is how the brain naturally prepares for sleep.
While these over-the-counter sleep aids can help you fall asleep, they are not recommended for long-term use due to the associated health risks. Instead, experts recommend alternative treatments for insomnia, such as cognitive behavioural therapy (CBT), good sleep hygiene, and melatonin supplements. CBT can help to adjust your circadian rhythm and reduce anxiety about insomnia, while melatonin supplements help promote sleep by raising melatonin levels in the body.
If you are experiencing chronic insomnia, it is important to talk to a healthcare professional. They can help address any underlying medical issues and may prescribe appropriate medications.
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Antihistamines are not recommended for pregnant or nursing women as sleep aids
Antihistamines are not recommended as a sleep aid due to their potential side effects and lack of research supporting their effectiveness. They can cause drowsiness, altered mental state, urinary retention, dry mouth, and sleepwalking. Additionally, long-term use may lead to harmful side effects, especially in older adults, and can increase the risk of dementia and Alzheimer's disease.
First-generation antihistamines, such as chlorpheniramine and tripelennamine, are considered relatively safe during pregnancy. However, it is important to carefully assess the risks and benefits of taking any medication during pregnancy, as there is limited data on the safety of newer antihistamines.
Pregnant women should always consult their physician before taking any medication, including antihistamines, to ensure the safest option for themselves and their fetus.
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Anticholinergic antihistamines may increase the risk of dementia and Alzheimer's disease
While antihistamines can make you feel sleepy, it is not recommended to take them as a sleep aid. They are not effective in improving overall sleep quality and may even have the opposite effect, causing hyperactivity, especially in children. Additionally, long-term use of antihistamines may lead to harmful side effects, especially in older adults.
Antihistamines, such as diphenhydramine (found in Benadryl) and doxylamine succinate, are examples of anticholinergic drugs. Anticholinergic drugs inhibit the action of acetylcholine, a neurotransmitter that plays a crucial role in several brain functions, including short-term memory and thinking. By blocking acetylcholine, these drugs can produce cognitive impairment that may persist even after discontinuing their use.
Several studies have found a link between the long-term use of anticholinergic medications and an increased risk for dementia and Alzheimer's disease. A 2021 review of 14 studies showed that higher exposure to these medications was associated with a higher risk of dementia and Alzheimer's. Another study tracked the health of 3,500 participants aged 65 and older and found that those who used anticholinergic drugs were more likely to develop dementia, with a 54% higher risk associated with taking these drugs for three years or more compared to shorter durations.
While these studies suggest an association between anticholinergic antihistamines and an increased risk of dementia and Alzheimer's disease, they do not establish a direct causal relationship. However, due to the potential side effects and the risk of cognitive impairment, it is generally recommended to avoid the long-term use of anticholinergic antihistamines, especially in older adults. If you are experiencing insomnia or sleep difficulties, it is advisable to consult a healthcare professional who can recommend alternative treatments or medications that are safer for long-term use.
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Frequently asked questions
It is not recommended to take antihistamines with sleeping pills as this can have harmful side effects. Antihistamines can be purchased over the counter and may be used occasionally to help with sleep, but they are not recommended for long-term use or in combination with other sleep aids.
The side effects of taking antihistamines with sleeping pills can include an altered mental state, urinary retention, dry mouth, sleepwalking, and other parasomnias. Antihistamines can also cause cognitive impairment that persists even after you stop taking them and may increase the risk of dementia and Alzheimer's disease.
Yes, there are alternative sleep aids such as melatonin, valerian, good sleep hygiene, and cognitive behavioural therapy (CBT). It is recommended to try nondrug treatments first, especially for older adults, as there may be safer ways to improve sleep.









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