
Sleep disturbances are common during pregnancy, with issues often peaking in the third trimester due to physical discomforts such as frequent urination, nausea, and heartburn. While there are over-the-counter and prescription medications available to help with sleep, it is important to carefully consider the pros and cons of taking any sleep aids during pregnancy, as there is limited research on their safety for pregnant people and fetuses. Sleep-Eze, for example, is a medication that should not be used during pregnancy unless the benefits are deemed to outweigh the risks. Always consult with a healthcare provider before starting any new medication or supplement during pregnancy.
Sleep-Eze Characteristics During Pregnancy
| Characteristics | Values |
|---|---|
| Should you take it during pregnancy? | This medication should not be used during pregnancy unless the benefits outweigh the risks. |
| What to do if you become pregnant while taking this medication? | Contact your doctor immediately. |
| What are the side effects? | Diphenhydramine can worsen bladder problems and cause drowsiness/reduced alertness. |
| What to do if you have trouble sleeping for longer than 2 weeks? | Contact your doctor before taking this medication. |
| What if you have thyroid disease? | Discuss with your doctor how this medication may affect your medical condition. |
| What if you are breastfeeding? | This medication may pass into breast milk. Talk to your doctor about whether you should continue breastfeeding. |
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What You'll Learn
- Sleep-Eze is not recommended during pregnancy unless benefits outweigh risks
- Melatonin supplements are popular but lack research on their impact during pregnancy
- Unisom is considered safe for treating insomnia during pregnancy
- Benzodiazepines are not recommended due to adverse effects on pregnancy and the baby
- Zolpidem is associated with an increased risk of low birth weight and preterm delivery

Sleep-Eze is not recommended during pregnancy unless benefits outweigh risks
Sleep-Eze is a medication that contains diphenhydramine, an antihistamine that can be used to treat insomnia. While it can be purchased over the counter, it is not recommended for use during pregnancy unless the benefits outweigh the risks. This is because there is limited research on the safety of sleep aids for pregnant people and their fetuses.
Pregnancy can bring about physical changes that make it difficult to sleep. Sleep disturbances are common during pregnancy, affecting around three-quarters of pregnant individuals, with issues often peaking in the third trimester due to bodily discomforts such as frequent urination, nausea, and heartburn. Hormonal changes can also affect breathing, and some pregnant individuals can develop sleep apnea, which can further interfere with sleep.
While Sleep-Eze may be tempting to use for better sleep during pregnancy, it is important to prioritize the safety of both the pregnant individual and the fetus. The lack of research on the safety of sleep aids during pregnancy makes it challenging to determine the true safety of taking Sleep-Eze or any other sleeping pills during this time. As a result, healthcare providers may opt not to recommend any sleep aids during pregnancy.
However, it is also essential to consider the negative consequences of sleep deprivation during pregnancy. In such cases, a healthcare provider may determine that the benefits of certain sleep aids, including Sleep-Eze, outweigh the risks. Pregnant individuals should consult their healthcare provider before taking any sleep aids to ensure they are making an informed decision regarding their own and their fetus's health.
Additionally, there are alternative approaches to improving sleep during pregnancy that do not involve medications. These include limiting caffeine intake, reducing fluid consumption in the evening, and avoiding heavy or spicy meals before bedtime to prevent heartburn and indigestion. Addressing underlying pregnancy discomforts and improving "sleep hygiene" through practices like drinking tea, taking warm showers, meditating, or reading before bed can also aid sleep without pharmaceuticals.
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Melatonin supplements are popular but lack research on their impact during pregnancy
Sleep disturbances are common during pregnancy, affecting 77% of pregnant individuals, with issues peaking in the third trimester due to physical discomforts such as frequent urination, nausea, and heartburn. Many pregnant women experience some degree of sleep disturbance, with severe disruption requiring some type of intervention. Melatonin is a popular natural remedy for sleep problems, and it is a hormone secreted by the pineal gland that regulates normal sleep-wake cycles. It is sold over the counter as a dietary supplement. However, the amount of melatonin delivered by over-the-counter preparations typically exceeds the quantities normally produced by the body.
There is limited research on the safety of melatonin supplements for pregnant people and fetuses. While melatonin levels tend to naturally increase with each trimester during pregnancy, taking melatonin supplements might not be a good idea for pregnant women without a documented health issue associated with low melatonin levels. The potential risk of supplementing with melatonin is having too much of it in the body. Additionally, studies have shown that melatonin supplements can cross the placenta and raise melatonin levels in fetuses.
Animal studies have shown that melatonin supplementation can decrease the risk of pre-eclampsia, preterm birth, and intrauterine growth retardation (IUGR). However, in another animal study, melatonin supplementation negatively impacted litter size and the growth and mortality rates of the pups. There is a lack of randomized controlled trials examining the efficacy and safety of melatonin as a treatment for sleep disorders during pregnancy. While clinical trials have not suggested major safety concerns, there is a need for more clinical studies on sleep disorders and melatonin during pregnancy.
Pregnant individuals should consult a healthcare provider before taking melatonin or any supplement during pregnancy. A healthcare provider can consider an individual's health history, medications, and supplements to account for potential problems and interactions.
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Unisom is considered safe for treating insomnia during pregnancy
Sleep disturbances are common during pregnancy, affecting 77% of pregnant individuals, with issues peaking in the third trimester due to bodily discomforts such as frequent urination, nausea, and heartburn. Unisom is an over-the-counter medication used to treat short-term insomnia and is also used in pregnancy with vitamin B6 to treat morning sickness. It is considered safe to take the recommended adult dosage of Unisom during pregnancy, as the FDA indicates that the risk of birth defects and other pregnancy complications is low. The U.S. Food and Drug Administration (FDA) generally recognizes Unisom as safe and effective, but the medicine is intended to treat temporary sleeplessness and is not a long-term solution.
Unisom is a nighttime sleep aid that contains the active ingredient doxylamine succinate, an antihistamine that blocks how histamine works in the body and makes you feel sleepy. In addition to helping with occasional insomnia, Unisom is used in combination with vitamin B6 to treat nausea and vomiting during pregnancy, according to the American College of Obstetricians and Gynecologists (ACOG). Unisom is considered safe to use during pregnancy by major medical groups, including the FDA and ACOG. “It’s been around for a really long time,” says Bernstein, adding that studies have shown there’s no legitimate concern.
However, it is still important to check with your doctor before taking any medication during pregnancy, including Unisom. You’ll want to ask your doctor about the medication’s safety, potential effects on your baby, and ensure it won’t interact with other medications you may be taking. If you are only having trouble sleeping while pregnant, your doctor might recommend Benadryl. Unisom is likely to be recommended for consistent nausea and vomiting during pregnancy.
If you do not feel comfortable taking medications during pregnancy, there are non-medication options for nausea and vomiting. Some medication-free ways to manage insomnia include avoiding caffeine, exercising daily, keeping screens out of the bedroom, and keeping the bedroom cool and dark.
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Benzodiazepines are not recommended due to adverse effects on pregnancy and the baby
Sleep-Eze is a medication that contains diphenhydramine, an antihistamine. While diphenhydramine is considered safe during pregnancy, Sleep-Eze is not recommended for pregnant women due to the potential risks associated with the medication.
Benzodiazepines, including medications such as Valium, Ativan, and Xanax, are not recommended during pregnancy due to adverse effects on both the mother and the baby. Research has shown that the use of benzodiazepines during pregnancy may increase the risk of miscarriage, preterm labour, low birth weight, and neonatal withdrawal symptoms. One study of 2,497 pregnant women who used the nonbenzodiazepine drug zolpidem found an increased risk of low birth weight, small-for-gestational age infants, preterm delivery, and C-sections compared to pregnant women who did not use the drug.
While the research on sleeping pills during pregnancy is limited, healthcare providers may recommend addressing sleep difficulties through lifestyle modifications or supplements before resorting to medication. Melatonin supplements, for example, are considered relatively safe during pregnancy, although more research is needed to confirm their effectiveness and safety. Pregnant women should always consult with their healthcare provider before starting any new medication or supplement to weigh the benefits against the risks.
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Zolpidem is associated with an increased risk of low birth weight and preterm delivery
Sleep-Eze, also known as diphenhydramine, is an over-the-counter sleep aid that is generally not recommended for use during pregnancy. While it is not explicitly listed as a medication to avoid during pregnancy, it is always advisable to consult a healthcare provider before taking any medication or supplement while pregnant.
Zolpidem, a nonbenzodiazepine sedative, has been associated with an increased risk of adverse pregnancy outcomes. In a study of 2,497 pregnant women, those who used zolpidem had a higher incidence of low birth weight, small-for-gestational-age infants, preterm delivery, and C-sections compared to those who did not use the drug. These findings highlight the potential risks associated with zolpidem use during pregnancy.
The study's results indicated that zolpidem use during pregnancy was significantly associated with a higher risk of low birth weight. Low birth weight can have several negative implications for the newborn, including an increased risk of health complications and developmental issues. As a result, it is crucial for pregnant individuals to be aware of this potential risk when considering the use of zolpidem.
Additionally, the study found a higher rate of preterm delivery among pregnant women who used zolpidem. Preterm delivery, or birth before 37 weeks of gestation, can lead to various health problems for the newborn, such as respiratory distress syndrome and feeding difficulties. Therefore, the association between zolpidem and preterm delivery is a significant concern that should be carefully considered by pregnant individuals and their healthcare providers.
While the study's findings suggest an increased risk of low birth weight and preterm delivery with zolpidem use during pregnancy, more research is needed to confirm these results. It is important to note that the decision to use any medication during pregnancy should be made in consultation with a healthcare provider, weighing the potential benefits against the risks for both the mother and the fetus.
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Frequently asked questions
Sleep-Eze should not be used during pregnancy unless the benefits outweigh the risks. If you are pregnant and taking Sleep-Eze, you should contact your doctor immediately.
Doctors may recommend medication to help pregnant women sleep if they have severe sleep disorders or other medical conditions that cause sleeping problems. Some over-the-counter medications considered safe for treating insomnia during pregnancy include Benadryl (diphenhydramine) and Unisom Sleep Tabs (doxylamine). Melatonin supplements may also be suggested by providers for pregnant women who continue having trouble falling asleep after trying non-medication alternatives.
Research on the safety of sleep medication during pregnancy is limited. Prescription sleep medications should be avoided during late pregnancy as they may cause breathing and muscle tone problems in infants. Benzodiazepines, a common ingredient in sleeping pills, has been associated with an increased risk of miscarriage, preterm labour, low birth weight, and C-sections.
Yes, there are natural alternatives to sleep medication during pregnancy. These include improving your "sleep hygiene" by drinking tea, taking a warm shower, meditating, or trying some light reading before bed. Lifestyle modifications and supplements are recommended by some healthcare providers before resorting to medication.
Some people may experience side effects such as drowsiness and reduced alertness. Sleep-Eze can also worsen symptoms of bladder problems. It is important to consult your doctor if you notice any worrying symptoms while taking this medication.










































