
Benadryl is an over-the-counter antihistamine medication used to treat allergies, motion sickness, and nausea. Its active ingredient, diphenhydramine, induces drowsiness by blocking histamine, a molecule that keeps people awake during the day. While Benadryl can be effective in aiding sleep, it is not recommended for long-term use due to potential side effects, tolerance development, and decreased effectiveness over time. Alternatives such as improving sleep hygiene and prescription sleep aids may be safer and more effective options for treating insomnia.
| Characteristics | Values |
|---|---|
| Active Ingredient | Diphenhydramine |
| Dosage | 25 mg or 50 mg |
| Dosage Time | 20 minutes to 30 minutes before bedtime |
| Usage Duration | Not more than 2 weeks (14 days) at a time |
| Side Effects | Dry mouth, dry eyes, trouble urinating, confusion, nervousness, dizziness, headache, nausea, loss of appetite, seizures, vomiting, sleepwalking, parasomnias, hyperactivity, slowed reaction time |
| Age Restrictions | Not suitable for children under 12, caution advised for adults over 65 |
| Availability | Over-the-counter (OTC) |
| Alternative Names | Advil PM, Excedrin PM, Motrin PM, Tylenol PM Extra Strength, Ambien |
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What You'll Learn

Benadryl's side effect of drowsiness
Benadryl (diphenhydramine) is an over-the-counter antihistamine medication that treats allergies, motion sickness, nausea, and cold symptoms. Its active ingredient, diphenhydramine, is an antihistamine that affects the body's natural sleep-wake cycle, making it easier to fall asleep. This side effect of drowsiness is often welcomed by those experiencing allergies or a cold, as it helps to alleviate the symptoms that may otherwise keep them awake.
However, while Benadryl can be effective in aiding sleep, it is not intended for long-term use as a sleep aid. Research has shown that the more someone takes Benadryl to help them sleep, the less effective it becomes. One study found that after only four days of taking diphenhydramine for sleep, it was no more effective than a placebo. Additionally, the drowsiness caused by Benadryl may continue into the following day, impacting an individual's alertness and ability to function.
Benadryl can also cause other side effects, including nervousness, dry nose, mouth, and throat, dizziness, headache, nausea, loss of appetite, trouble urinating, and constipation. These side effects are generally mild and well tolerated in young, healthy individuals. However, they can pose a risk to older adults, in whom drug side effects can be longer-lasting and more severe, including confusion and an increased risk of falling.
It is important to note that Benadryl should not be used as a sleep aid in children under 12. For children between 2 and 6 years of age, Benadryl should only be used under the supervision of a pediatrician. Overall, while Benadryl's side effect of drowsiness may provide short-term relief for sleep difficulties, it is not a suitable long-term solution and may even lead to decreased effectiveness over time.
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Benadryl is not suited for long-term use
Benadryl is an over-the-counter antihistamine medication that treats allergies, motion sickness, nausea, and cold symptoms. Its active ingredient, diphenhydramine, induces drowsiness by blocking histamine, a molecule that keeps people awake during the day. While Benadryl can help people fall asleep, it is not suited for long-term use for several reasons.
Firstly, Benadryl is only intended for the short-term treatment of insomnia. The American Academy of Sleep Medicine (AASM) advises against its regular use for insomnia and other sleep problems. This is because Benadryl loses effectiveness over time. Research shows that the more someone takes Benadryl to help them sleep, the less effective it becomes. One study found that after just four days of use, Benadryl was no more effective than a placebo.
Secondly, Benadryl can cause side effects that may make people reconsider taking it as a sleep aid. While these side effects are generally mild and well-tolerated in young, healthy patients, they can pose risks, especially for older adults. Side effects may include nervousness, dry nose, mouth, and throat, dizziness, headache, nausea, loss of appetite, and trouble urinating. In older adults, Benadryl is more likely to cause side effects such as dry mouth and eyes, trouble urinating, and confusion. It may also increase the risk of falling.
Thirdly, Benadryl can cause daytime sleepiness and slow reaction times, which can affect motor skills and persist into the following day. Additionally, taking too much Benadryl can increase the risk of more serious side effects, including vomiting and seizures. It is important to note that Benadryl should not be used in children under 12, as drug side effects can be longer-lasting in this age group.
Finally, Benadryl may not provide any long-term benefit for sleep. While it can help people fall asleep, it does not necessarily improve overall sleep quality. In some cases, it can even have the opposite effect, causing hyperactivity, especially in children. Therefore, it is recommended to consult a healthcare professional if you have been taking Benadryl consistently for two weeks or more. They may advise you to improve your sleep hygiene, recommend alternative sleep aids, or address any underlying medical conditions that could be causing insomnia.
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Benadryl's active ingredient, diphenhydramine
Benadryl is a medication that is typically used to treat allergies and cold symptoms. Its active ingredient is diphenhydramine, an antihistamine that blocks histamine from binding to H1 receptors in the body. Histamine is a molecule that is responsible for many allergy symptoms, such as a runny nose, sneezing, and itchy eyes. By blocking histamine, diphenhydramine relieves allergy symptoms and also causes drowsiness, which is why some people use Benadryl as a sleep aid.
Diphenhydramine is found in various Benadryl products, including tablets, capsules, liquids, dissolving and chewable tablets, and topical creams. The recommended dosage for sleep in adults and children aged 12 and older is 50 mg taken orally 30 minutes before bedtime. It is important to note that Benadryl should not be taken for longer than two consecutive weeks and is not recommended for long-term insomnia treatment.
While Benadryl can help with occasional sleeplessness, it may not be the best choice for a sleep aid due to its side effects. These can include nervousness, dry nose, mouth, and throat, dizziness, headache, nausea, loss of appetite, and blurred vision. In older adults, Benadryl may cause additional side effects, such as dry mouth and eyes, trouble urinating, and confusion. It is important to consult a healthcare professional before taking Benadryl for sleep, especially if taken for an extended period, to ensure it is safe and appropriate for the individual.
Diphenhydramine is also found in other over-the-counter sleep aid products, such as Tylenol PM Extra Strength (acetaminophen/diphenhydramine) and Advil PM (ibuprofen/diphenhydramine). It is crucial to check the labels of all medications to ensure you are not accidentally doubling up on diphenhydramine or taking it in combination with other substances that may cause adverse interactions.
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Benadryl's side effects
Benadryl (diphenhydramine) is an over-the-counter antihistamine used to treat allergies, allergic reactions, and cold symptoms. It is also used to prevent and treat motion sickness and to treat insomnia. Benadryl is available as a prescription and over-the-counter medication. It comes in many different forms, including oral tablets, capsules, liquids, dissolving and chewable tablets, and topical creams.
While Benadryl can be effective in helping people fall asleep, it is not recommended as a long-term sleep solution due to its potential side effects. The most commonly reported side effects of Benadryl include:
- Sleepiness/drowsiness
- Dizziness
- Disturbed coordination
- Headache
- Dry mouth, nose, and throat
- Nausea
- Loss of appetite
- Nervousness
More serious side effects that have been reported with Benadryl include changes in blood cell levels, such as decreased red blood cell levels. Additionally, Benadryl may not be suitable for older adults as it can cause side effects such as dry mouth and eyes, trouble urinating, and confusion. It may also increase the risk of falling.
Benadryl is not recommended for long-term use, as it can lead to loss of effectiveness and daytime sleepiness. It is important to consult a healthcare professional if you have been consistently taking Benadryl for two weeks or more.
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Benadryl alternatives
While Benadryl can help people fall asleep, it may not be the best choice as a sleep aid. Benadryl is not recommended for long-term use due to its side effects and potential for loss of effectiveness over time.
Healthy sleep habits
Before turning to medication, it is advisable to try improving your sleep hygiene and making changes to your daily routine to promote better sleep. This can include practices such as maintaining a consistent sleep schedule, creating a relaxing bedtime routine, and limiting screen time before bed.
Over-the-counter sleep aids
There are various over-the-counter sleep aids available that do not contain antihistamines. These can be recommended by a pharmacist or healthcare professional and may be a safer option for occasional sleeplessness.
Consulting a physician or sleep specialist
If you suffer from long-term insomnia or persistent sleep difficulties, it is advisable to consult a physician or sleep disorders specialist. They can help address any underlying medical issues that may be causing your insomnia, such as obstructive sleep apnea, depression, or circadian rhythm disorders.
Alternative medications
If you are taking medications that may be interfering with your sleep, consult your pharmacist or physician about alternative medications that may have fewer impacts on your sleep. For example, if you are taking a decongestant like Sudafed (pseudoephedrine) in the evening, it may be causing sleeping problems.
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Frequently asked questions
Benadryl is an over-the-counter antihistamine medication that can be used as a sleep aid due to its drowsiness side effect. However, it is not recommended for long-term use and should not be used for more than 14 consecutive days.
Side effects of Benadryl include dry mouth and eyes, trouble urinating, dizziness, headache, nausea, loss of appetite, nervousness, and confusion. It may also increase the risk of falling and cause sleepwalking or other parasomnias.
The recommended dosage for adults and children aged 12 and older is 50 mg taken orally 20 to 30 minutes before bedtime. It is important to note that you should not take more than the recommended dose or take it for longer than two weeks without consulting a healthcare professional.
Yes, there are several over-the-counter alternatives to Benadryl that may be safer and more effective. Improving sleep hygiene, such as maintaining a regular sleep schedule and avoiding electronics and caffeine before bedtime, can also help improve sleep quality. If these measures do not help, a healthcare provider may recommend a prescription sleep aid.


























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