
Sleeping pills are medications that can help treat sleep disorders, insomnia, or difficulty falling asleep. They are available over the counter (OTC) or by prescription, with prescription pills generally being stronger. Sleeping pills can be effective, but they can also have side effects and the potential for addiction, so they are not recommended for long-term use. They should be taken at the right time of night to avoid daytime drowsiness, and users should be careful not to overdose or combine them with alcohol.
| Characteristics | Values |
|---|---|
| Availability | Over the counter (OTC), as natural supplements or by prescription |
| OTC Examples | Antihistamines (e.g. diphenhydramine, doxylamine), melatonin, L-tryptophan, valerian |
| Prescription Types | Benzodiazepines, Non-benzodiazepines (Z-drugs), Antidepressants, Antipsychotics, Nonbenzodiazepine receptor agonists |
| Benzodiazepines | Powerful hypnotics, treat insomnia, relieve anxiety, improve learning and memory. Include alprazolam, clonazepam, diazepam, lorazepam. |
| Non-benzodiazepines (Z-drugs) | Zolpidem, Ambien, Zopiclone, Eszopiclone (Lunesta), Zaleplon (Sonata) |
| Antidepressants | Treat depression, stress, anxiety, migraines, irritable bowel syndrome (IBS). Include Doxepin (Silenor), amitriptyline, nortriptyline. |
| Antipsychotics | Quetiapine (Seroquel), olanzapine (Zyprexa), risperidone (Risperdal) |
| Nonbenzodiazepine receptor agonists | Suvorexant (Belsomra), lemborexant (Dayvigo), daridorexant (Quviviq) |
| Side Effects | Dizziness, nausea, fatigue, irritability, depression, drowsiness, confusion, memory issues, parasomnia behaviours, addiction, dependency, upset stomach |
| Precautions | Do not combine with alcohol or other medications, do not take every night, follow a sleep schedule, limit fluid intake before bed, avoid caffeine, nicotine and alcohol close to bedtime |
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What You'll Learn
- Sleeping pills are available over the counter, as natural supplements, or by prescription
- Sleeping pills can have side effects, so they shouldn't be used long-term
- Sleeping pills can be effective for chronic insomnia
- Sleeping pills are strong hypnotics that induce sleepiness
- Sleeping pills can be combined with cognitive-behavioural therapy for better results

Sleeping pills are available over the counter, as natural supplements, or by prescription
Natural sleep aids are classified as dietary supplements, which means they are not regulated as strictly as medications. The Food and Drug Administration does not verify the safety, efficacy, or labelling of natural sleep aids. It is important to research products and look for third-party certifications to ensure quality.
Some popular natural sleep aids include melatonin, glycine, and L-theanine. Melatonin is a natural hormone that helps regulate sleep and can be useful for those with naturally low levels, often due to night-time light exposure, aging, or disease. However, it may interact with other medications and is not recommended for everyone. Glycine is an amino acid and neurotransmitter that supports circadian rhythms involved in sleep. Taking a small dose before bed may improve sleep quality and reduce daytime sleepiness for those with insomnia. L-theanine is another amino acid that occurs naturally in tea plants and may help reduce stress and anxiety, promoting relaxation and better sleep.
In addition to natural supplements, some sleeping pills are available over the counter at pharmacies, while others require a prescription from a doctor. It is important to carefully read the instructions and follow the recommended dosage for any over-the-counter or prescription sleeping pills.
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Sleeping pills can have side effects, so they shouldn't be used long-term
Sleeping pills are medications that can help treat insomnia and make you feel drowsy and relaxed. They are available over the counter (OTC) as natural supplements or by prescription. While they can be effective in aiding sleep, sleeping pills can have side effects, and therefore, should not be used long-term.
Sleeping pills can cause a range of side effects, including constipation, diarrhoea, muscle weakness, digestive problems, and worsening of snoring and sleep apnea. Additionally, they can interfere with normal breathing and be dangerous for individuals with certain chronic lung problems such as asthma, emphysema, or chronic obstructive pulmonary disease (COPD). Common side effects of prescription sleeping pills include a burning or tingling sensation in the extremities.
Furthermore, sleeping pills can lead to dependence and rebound insomnia. When taken night after night, the body may become dependent on them, and stopping the medication can result in insomnia returning worse than before. This can create a cycle of reliance on sleeping pills, making it challenging to stop their use. It is important to consult a healthcare provider when considering the use of sleeping pills and to discuss alternative therapies or treatments for sleep issues.
Sleeping pills can also cause parasomnias, which are complex sleep behaviours that occur while the individual is still mostly asleep. Parasomnias can include sleepwalking, sleep eating, making phone calls, or even driving while not fully awake. These behaviours can be dangerous and may result in injuries or accidents. Additionally, sleeping pills can cause confusion, memory issues, and daytime drowsiness, impacting an individual's ability to drive, work, or perform tasks requiring focus and attention.
While sleeping pills can provide short-term relief from sleeplessness, their side effects and potential for dependence make them unsuitable for long-term use. It is essential to weigh the risks and benefits before taking sleeping pills and to explore alternative treatments, such as cognitive behavioural therapy (CBT), to improve sleep quality and duration.
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Sleeping pills can be effective for chronic insomnia
Sleeping pills are medications that can help treat insomnia by making you feel drowsy and relaxed. They are available over the counter (OTC), as natural supplements, or by prescription. While they can be effective in aiding sleep, they should be used cautiously and are not recommended for long-term use due to potential side effects and the risk of dependency or addiction.
Prescription sleeping pills are typically stronger than over-the-counter ones and may include medications such as zaleplon, zolpidem, and eszopiclone (Lunesta). These prescription medications can help with chronic insomnia, but it is essential to use them under a doctor's guidance. Intermittent use, or taking them occasionally during acute bouts of insomnia, may be more effective in managing chronic insomnia while mitigating the risk of dependency.
Over-the-counter sleep aids often contain antihistamines, which treat allergies but can also cause drowsiness. While antihistamines can make you feel sleepy, they are not recommended for long-term use as their effectiveness decreases over time. Some people opt for natural supplements like melatonin or valerian root, which promote sleep. However, the effectiveness of melatonin for long-term insomnia treatment is not fully proven, and the quality of supplements can vary due to a lack of regulation.
Sleeping pills should be used with caution and in conjunction with other strategies for managing chronic insomnia. Cognitive Behavioral Therapy for Insomnia (CBT-I) is recommended as a first-line, long-term treatment option. It involves working with a therapist, doctor, or other professional to address sleep issues. Relaxation or meditation therapy, sleep education, and sleep restriction therapy are also components of CBT-I that can help improve sleep quality.
Additionally, maintaining a consistent sleep schedule and improving sleep hygiene are crucial for managing chronic insomnia. This includes sticking to the same bedtime and wake-up time, even on weekends, and limiting fluid intake close to bedtime to reduce the need for middle-of-the-night bathroom breaks. Avoiding caffeine, nicotine, and alcohol before bed can also promote better sleep. While alcohol may make you feel sleepy, it can disrupt your sleep, causing frequent wake-ups during the night.
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Sleeping pills are strong hypnotics that induce sleepiness
Sleeping pills are medications that can help treat sleep disorders, insomnia, or difficulty falling asleep. They are available over the counter, as natural supplements, or by prescription. Sleeping pills can be effective in treating chronic insomnia, but they can also have side effects and should not be used long-term.
Sleeping pills that are prescription medications containing tranquilizers are often referred to as "Z-drugs" or benzodiazepines. These are powerful hypnotics that act on the brain's GABA neurotransmitters, inducing sleepiness and promoting relaxation. Benzodiazepines are generally recommended for short-term use due to their potential for abuse, addiction, and dependence. Non-benzodiazepine Z-drugs, such as Zolpidem, Ambien, and Zopiclone, are the most frequently prescribed due to their minimal side effects and low potential for drug tolerance and addiction.
Antihistamines, which are commonly found in over-the-counter sleep aids, can also cause drowsiness. However, they are not recommended for long-term use as their effectiveness wears off over time. Melatonin supplements, which mimic the body's natural sleep hormone, are another option for those struggling with sleep. While melatonin receptor agonists like ramelteon (Rozerem) are available by prescription, melatonin supplements can also be purchased over the counter.
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Sleeping pills can be combined with cognitive-behavioural therapy for better results
Sleeping pills are medications that can help with sleep. They are available over the counter (OTC), as natural supplements, or by prescription. While they can be effective, sleeping pills should not be used long-term as they can have side effects. These side effects include chronic fatigue, confusion or memory issues, parasomnia behaviours, problems focusing or completing tasks, and severe upset stomach. A sleeping pill overdose can also occur if you take more than the recommended amount or combine them with alcohol or other medications.
Cognitive-behavioural therapy (CBT) is a type of sleep therapy that can help reset your views on sleep and aid relaxation. CBT can be used in combination with hypnotic medications for the short-term treatment of insomnia. In a clinical trial, 160 adults with persistent insomnia received either CBT alone or CBT plus zolpidem, a non-benzodiazepine receptor agonist, for six weeks. After this initial treatment, they received a second extended treatment for another six months. While the efficacy of combined therapy for insomnia is still unclear, it can be a viable option for those seeking short-term relief from sleep issues.
Combining CBT with sleeping pills may offer several potential benefits. Firstly, CBT can help address the underlying psychological factors contributing to sleep issues. By changing negative thoughts and behaviours associated with sleep, individuals can improve their sleep habits and hygiene. Secondly, the use of sleeping pills can provide immediate relief from insomnia, allowing individuals to experience improved sleep while undergoing CBT. This combination approach may be particularly beneficial for those struggling with severe sleep deprivation, as it addresses both the immediate need for sleep and the long-term goal of maintaining healthy sleep habits.
However, it is important to note that the use of sleeping pills should be carefully monitored by a healthcare professional. While they can be effective in the short term, they are not intended for long-term use. Sleeping pills may have side effects, and their effectiveness may wear off over time. Additionally, combining sleeping pills with certain substances, such as alcohol, can lead to excessive drowsiness and increase the risk of injuries and memory issues. Therefore, it is crucial to seek professional guidance when considering the use of sleeping pills, whether in conjunction with CBT or as a standalone treatment.
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Frequently asked questions
Sleeping pills are medications that can help treat insomnia, restless sleep, or difficulty falling asleep. They are available over the counter, as natural supplements, or by prescription.
Examples of prescription sleeping pills include:
- Benzodiazepines (BZD)
- Zolpidem (Ambien)
- Zopiclone
- Eszopiclone (Lunesta)
- Zaleplon (Sonata)
- Suvorexant (Belsomra)
- Lemborexant (Dayvigo)
- Daridorexant (Quviviq)
Examples of over-the-counter (OTC) sleeping pills include antihistamines such as:
- Diphenhydramine (ZzzQuil)
- Doxylamine (Unisom)








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