
Headaches are a common ailment that can be treated with a variety of medications, depending on the type and severity. The most common type of headache is a tension headache, which can be treated with over-the-counter medicines such as paracetamol, aspirin, and ibuprofen. Migraines, on the other hand, may require prescription medications such as triptans, beta-blockers, or anti-nausea drugs. Preventative medications can also be used to reduce the frequency and severity of headaches, but these may have unpleasant side effects. It's important to consult a healthcare provider to determine the best course of treatment, as overuse of headache medications can lead to new or worse symptoms. In addition to medication, adequate hydration, biofeedback, and sufficient sleep are natural ways to alleviate headaches.
| Characteristics | Values |
|---|---|
| Best medicine for headaches | Depends on the headache frequency and severity |
| First step | Trying an over-the-counter (OTC) medicine |
| OTC medicines | Aspirin, Ibuprofen, Acetaminophen, Naproxen Sodium, Celecoxib, Diclofenac, Meclofenamate, Orphenadrine, Antihistamines, Nonsteroidal anti-inflammatory drugs (NSAIDs) |
| Prescription medicines | Triptans, Sumatriptan succinate, Zolmitriptan, Rizatriptan, Naratriptan HCI, Almotriptan malate, Frovatriptan succinate, Eletriptan hydrobromide, Imitrex, Zomig, Maxalt, Amerge, Axert, Frova, Relpax, Botox, CGRP monoclonal antibodies, Dihydroergotamine, Lasmiditan, Gepants, Methocarbamol, Beta-blockers, Amitriptyline, Valproate, Topiramate, Codeine, Morphine |
| Side effects | Sleepiness, Dizziness, Dry mouth, Fatigue, Nausea, Vomiting, Constipation, Weight changes, Chest pain, Numbness of fingers and toes, Heartburn, Upset stomach |
| Preventive measures | Adequate hydration, Biofeedback, Enough sleep, Dietary changes, Magnesium |
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What You'll Learn
- Over-the-counter medicines for headaches include ibuprofen, aspirin, and acetaminophen
- Preventative medicines can be over-the-counter or prescription
- Prescription medications can be taken daily to reduce the frequency and severity of headaches
- Triptans are prescription drugs used for migraine relief
- Antidepressants may be prescribed to prevent migraines and mitigate side effects like sleepiness

Over-the-counter medicines for headaches include ibuprofen, aspirin, and acetaminophen
Over-the-counter (OTC) medicines are usually the first step in treating headaches. Doctors have not yet agreed on the best medicine for headaches, and it often takes time and experimentation to find the right treatment for each individual. It is important not to overuse headache medications, as this can lead to new or worse symptoms.
Ibuprofen is an over-the-counter medicine that can be used to treat headaches. It is a non-steroidal anti-inflammatory drug (NSAID) and is available under brand names such as Advil and Motrin IB. Other NSAIDs that can be used to treat headaches include naproxen (Aleve) and celecoxib (Celebrex, Elyxyb). NSAIDs are more powerful compared to acetaminophen because they also reduce inflammation.
Acetaminophen (Tylenol) is another over-the-counter medicine that can be used to treat headaches. It is considered a first-line treatment for headaches and is generally safe for pregnant people to take occasionally. However, acetaminophen is less powerful than NSAIDs like ibuprofen.
Aspirin is also an over-the-counter medicine that can be used to treat headaches. It is a pain reliever and can be combined with caffeine and acetaminophen to help with mild pain.
In addition to OTC medicines, there are also prescription medications for headaches, such as triptans and dihydroergotamine. Preventive medications, whether OTC or prescription, may also be used to reduce the frequency of headaches. These include beta-blockers, amitriptyline, and very low doses of antidepressants.
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Preventative medicines can be over-the-counter or prescription
Preventative medicines can be over-the-counter or prescribed. Over-the-counter medications are typically the first step in treating headaches. These include pain relievers such as aspirin, ibuprofen (Advil, Motrin IB), acetaminophen (Tylenol), and naproxen (Aleve). However, if headaches are frequent or severe, over-the-counter medicines may not be effective. In such cases, a doctor may prescribe medication to address the underlying cause of the headaches.
Pregnant individuals experiencing headaches can safely take acetaminophen (Tylenol) occasionally. It is important to consult a doctor if there are any red flags, such as sudden headaches, confusion, weakness in limbs, double vision, or vomiting.
Prescription medications can be taken daily to reduce the frequency and intensity of headaches. For those experiencing headaches at least 15 days a month, magnesium supplements may be recommended, as there is some evidence that migraine sufferers may have lower brain magnesium levels. Preventative migraine treatments include beta-blockers, tricyclic antidepressants like amitriptyline, and botulinum toxin injections (Botox).
Additionally, antihistamines such as Claritin (loratadine) and Xyzal (levocetirizine) are available over the counter and can help prevent allergy-related headaches by blocking histamine. Corticosteroid nasal sprays, available by prescription or over the counter, may also alleviate sinus headache symptoms by reducing inflammation and suppressing the immune system.
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Prescription medications can be taken daily to reduce the frequency and severity of headaches
The best medicine for headaches depends on the type of headache and its frequency and severity. While over-the-counter (OTC) medications are usually the first step in treating headaches, prescription medications can be taken daily to reduce the frequency and severity of headaches.
If you experience headaches more than twice a week, it is recommended to consult a doctor as there may be more effective treatments. Prescription medications can help manage chronic headaches and prevent them from occurring in the first place. These medications are designed to be taken regularly, often daily, to reduce the occurrence and intensity of headaches.
Preventive prescription medications can include beta-blockers, tricyclic antidepressants like amitriptyline, and other alternative antidepressants. These medications can help reduce the frequency of headaches and address associated symptoms such as sleepiness. It is important to note that these medications may have side effects, and your healthcare provider will work with you to regulate the dosage to maximize headache relief and minimize side effects.
For those who experience migraines, there are prescription medications specifically designed to prevent and treat these debilitating headaches. Examples include triptans, which block pain pathways that contribute to migraine pain, and calcitonin gene-related peptide (CGRP) monoclonal antibodies, which are newer injection treatments approved by the FDA. Additionally, OnabotulinumtoxinA (Botox) injections every 12 weeks can prevent migraines in some adults.
It is important to consult a healthcare professional to determine the most suitable prescription medication for your specific needs. They will consider your headache type, frequency, and severity, and any accompanying symptoms to recommend the best course of treatment.
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Triptans are prescription drugs used for migraine relief
There are several types of triptans available, including sumatriptan, naratriptan, zolmitriptan, rizatriptan, almotriptan, frovatriptan, and eletriptan. Sumatriptan is often the first triptan prescribed by doctors, and it is available in various forms, including oral tablets, nasal sprays, and injections. Other triptans, such as naratriptan and frovatriptan, may take longer to reach their maximum effect but have a longer duration of action.
It is important to note that triptans need to be prescribed by a healthcare provider, and they may consider several factors when deciding which triptan to prescribe. Triptans are generally well-tolerated, but they can cause side effects such as nausea, headache, sleepiness, dry mouth, dizziness, and fatigue. Additionally, triptans are not suitable for everyone, and individuals with certain medical conditions, such as cardiovascular disease or severe hepatic impairment, may need to avoid them.
To ensure the effectiveness of triptans, it is recommended to take them as soon as migraine symptoms start. They can be taken in multiple doses over 24 hours if needed, but it is important to follow the instructions provided with the medication. If triptans are not providing adequate relief, individuals should consult their healthcare provider, who may adjust the dosage or recommend alternative treatment options, such as gepants.
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Antidepressants may be prescribed to prevent migraines and mitigate side effects like sleepiness
Antidepressants are commonly used as a preventive treatment for migraines. They are not, however, a suitable treatment for acute migraine attacks. Amitriptyline is the antidepressant with the best evidence for use in migraine prevention. Nortriptyline is an alternative for patients who may not tolerate amitriptyline. The sedating effect of TCAs can be beneficial for patients with comorbid insomnia. SNRIs, including venlafaxine and duloxetine, have also shown efficacy in migraine prevention and may be the most effective treatments in patients with comorbid depression and migraine.
While antidepressants can be an effective preventive treatment for migraines, they may also cause substantial side effects. The side effects of antidepressants include sleepiness, dizziness, disturbed coordination, and behavioural changes. The burden of these side effects can be significant, and patients should be counselled about the possibility of withdrawal effects.
It is important to note that the effectiveness of antidepressants for migraine prevention may depend on the underlying cause of the headaches. Dr. Anixter states that headaches may be caused by various factors, including lack of sleep, allergies, sinus problems, medications, foods, vision deficits, and brain lesions. Therefore, it is crucial to consult a healthcare provider to determine the most appropriate treatment option for migraine prevention.
In addition to antidepressants, there are other preventive medications available for migraine treatment, which can be either over-the-counter (OTC) or prescription drugs. These medications aim to maximise headache relief and minimise side effects. Adequate hydration, biofeedback, sufficient sleep, and dietary changes are also recommended as part of migraine prevention and management.
Overall, while antidepressants may be prescribed to prevent migraines and mitigate side effects like sleepiness, it is important to consider the potential benefits and risks of this treatment option and explore other preventive measures to manage migraines effectively.
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Frequently asked questions
The best medicine for headaches depends on the type and severity of the headache. Over-the-counter medicines like aspirin, ibuprofen, acetaminophen, and naproxen sodium are a good first step. If your headaches are severe or persistent, you should consult a doctor, who may prescribe medication.
Some headache medications, such as triptans, can cause sleepiness as a side effect. However, it is important to consult your doctor or pharmacist before taking any medication, as side effects can vary from person to person.
Staying hydrated, getting enough sleep, and making dietary changes can help reduce headache attacks. If you experience headaches frequently, you should consult a doctor, who may recommend preventive therapy or magnesium supplements.
Abortive therapy medications are usually used for migraines. These drugs are most effective when taken at the first sign of symptoms. Examples include triptans, which are prescription drugs, and over-the-counter combination medications like Excedrin Migraine. Preventative treatments include beta-blockers, amitriptyline, and Botox injections.










































