
Sleeping pills are central nervous system depressants that slow down brain activity to help people rest. They are typically used to treat insomnia and other sleep disorders. While they can be effective in aiding sleep, sleeping pills have also been associated with an increased risk of suicidal thoughts and attempts. This risk is not limited to a specific type of sleeping pill, and it is important to note that overdose can occur when taking 60-90 times the prescribed dose, which can lead to death. If you or someone you know is experiencing suicidal thoughts, it is crucial to seek help immediately by contacting relevant support services.
| Characteristics | Values |
|---|---|
| Types of sleeping pills | Barbiturates, Benzodiazepines, Z-drugs (Eszopiclone, Zolpidem, Zaleplon), Trazodone, Antidepressants, Lunesta, Sonata |
| Overdose | Taking 60-90 times the intended dose can lead to death |
| Side effects of overdose | Extreme lethargy, abdominal pain, breathing trouble, clumsiness, nausea, dizziness |
| Treatment | Flumazenil, stomach pump, CPR |
| Prevention | Take only as prescribed, do not mix with opioids or alcohol |
| Support | National Suicide Prevention Hotline (1-800-273-8255), 988 Suicide & Crisis Lifeline |
What You'll Learn

Sleeping pills and suicide: Insomnia and mental health
Sleep is an essential part of our lives, and sleep disorders can have a significant impact on our mental health. Insomnia, a common sleep disorder, is characterised by difficulty falling asleep, staying asleep, or waking up too early, resulting in daytime impairments. The COVID-19 pandemic has exacerbated sleep problems, with many people experiencing "Coronasomnia" due to increased stress, isolation, and changes in daily routines.
The relationship between insomnia and mental health is complex and bidirectional. Insomnia can be both a symptom and a contributor to psychiatric disorders such as depression, anxiety, and even suicidal ideation. It is important to note that sleep disorders, including insomnia, increase the risk for suicide two to three times, independent of depression and other psychiatric illnesses. This means that individuals with insomnia are more likely to experience suicidal thoughts and behaviours, as supported by multiple studies.
Treating insomnia may help reduce suicide risk. While cognitive behavioural therapy (CBT-I) is recognised as a first-line treatment for insomnia, pharmacological treatments are also available. Prescription medications for insomnia include Z-drugs (zolpidem, eszopiclone, and zaleplon), trazodone, and sedative benzodiazepines (triazolam, temazepam, flurazepam). However, it is important to be cautious as these medications are associated with an increased risk of suicidal ideation, planning, and attempts.
Additionally, the misuse and overdose of sleeping pills can be dangerous and even life-threatening. Overdosing on sleeping pills, especially when combined with other substances like opioids or alcohol, can lead to serious health consequences or even death. If you or someone you know is experiencing suicidal thoughts or tendencies, it is crucial to seek help immediately by contacting emergency services or relevant hotlines, such as the National Suicide Prevention Hotline or the Suicide & Crisis Lifeline.
In conclusion, insomnia and mental health are closely interconnected, and the proper management of sleep disorders is essential for maintaining overall well-being. While prescription medications can be effective in treating insomnia, they should be used with caution due to their potential side effects and impact on suicidal ideation. Seeking professional help and adopting healthy sleep habits are crucial steps in addressing insomnia and improving mental health outcomes.
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Overdose amounts: How many pills is too many?
It is important to note that overdose amounts vary depending on the type of sleeping pill and the individual's overall health status. Sleeping pills are central nervous system depressants that slow down brain activity to help people rest. While newer pills contain milder compounds that are less potent and safer, high doses of sleeping pills can still be fatal.
For example, Ambien, a commonly prescribed sleeping pill, is typically taken at a 10mg dose. A user enters overdose limitations at 600 mg, and death is reported at doses higher than 2,000 mg. An overdose on Lunesta, another popular sleeping pill, can occur at approximately 90 times the intended dose, which is upwards of 270 mg. Fatal overdoses typically occur when mixed with depressants like benzodiazepines or alcohol. Similarly, it generally takes around 200 mg of Sonata to overdose.
Sleeping pill overdoses can cause extreme drowsiness, confusion, abdominal pain, slow or shallow breathing, loss of coordination, and drunk-like behaviour. In severe cases, an overdose can depress critical functions like breathing and heart rate, requiring emergency medical help. It is crucial to seek immediate medical attention if a sleeping pill overdose is suspected.
While it is difficult to determine the exact overdose amount for all sleeping pills, taking 60-90 times the intended dose of any sleeping pill can lead to an overdose. Additionally, mixing sleeping pills with other substances like opioids or alcohol can increase the risk of overdose and fatality. Therefore, it is essential to take sleeping pills only as prescribed by a healthcare provider to prevent overdose and reduce suicide risk.
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Mixing pills with other substances
It is important to note that suicide is never a solution. If you or someone you know is experiencing suicidal thoughts or tendencies, immediately call the National Suicide Prevention Hotline at 1-800-273-8255.
Mixing sleeping pills with other substances can increase the risk of overdose and death. Sleeping pills are central nervous system depressants that slow down brain activity to help individuals rest. When combined with other depressant substances, the risk of respiratory failure and death increases. For example, while a benzodiazepine overdose is rarely fatal on its own, mixing it with opioids can be deadly. Similarly, combining Restoril, a benzodiazepine, with sleeping pills during pregnancy can cause stillbirth.
Alcohol is another substance that should not be consumed with sleeping pills. Alcohol is also a central nervous system depressant, and combining it with sleeping pills can enhance the depressive effects on the body, leading to an increased risk of overdose and death. Additionally, certain opioids, such as OxyContin (oxymorphone) and Vicodin (hydrocodone), should be avoided when taking sleeping pills. The combination of these drugs has been a chief cause of drug overdose deaths in the United States.
It is also important to be cautious when taking sleeping pills with other medications, especially if they are not prescribed together. Sleeping pills can interact with other drugs, leading to unintended consequences. This includes enhancing the depressive effects on the body or causing adverse drug interactions. Therefore, it is crucial to follow the prescribed dosage and avoid mixing sleeping pills with other substances to reduce the risk of overdose and death.
Furthermore, individuals should be aware of the potential for addiction and dependence when taking sleeping pills. The development of tolerance and dependence can lead to unintended results and increase the risk of overdose. Mixing sleeping pills with other substances can also increase the likelihood of addiction and dependence. If you or someone you know is struggling with sleeping pill misuse or dependence, seeking professional help is essential. Treatment plans are available to help individuals safely manage their sleeping pill use and improve their overall well-being.
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Side effects of an overdose
It is important to note that all sleeping pills are central nervous system depressants that slow down brain activity to help a person rest. Taking a higher dose than prescribed or taking pills more frequently than prescribed can increase the risk of overdose. This risk is especially high when sleeping pills are taken with other substances such as opioids or alcohol.
Sleeping pills have been associated with suicide attempts and completed suicides in toxicological, epidemiological, and clinical studies. Z-drugs (zolpidem, eszopiclone, and zaleplon), commonly used to treat insomnia, have been linked to an increased risk of suicidal ideation, planning, and attempts. However, it is important to note that treating insomnia may reduce suicide risk.
The side effects of a sleeping pill overdose can vary depending on the type of medication and the dose taken. Some common side effects of a sleeping pill overdose include:
- Extreme lethargy
- Abdominal pain
- Breathing difficulties
- Clumsiness
- Drunk-like behavior
- Unanticipated behaviors or actions
- Brain injury from lack of oxygen
- Physical injury
- Vomiting
It is important to seek immediate medical attention if a sleeping pill overdose is suspected. Treatment may involve the administration of flumazenil, a benzodiazepine antagonist that helps reverse the effects of the overdose. In cases where opioids are also involved, naloxone can be administered to reverse the opioid overdose.
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Preventing suicide and seeking help
Suicide is a serious public health problem with long-lasting effects on individuals, families, and communities. It is also preventable. If you or someone you know is struggling with suicidal thoughts or tendencies, there are several resources available to help.
Firstly, it is important to recognize the warning signs of suicide, which can include feelings of hopelessness, helplessness, or worthlessness, as well as increased drug or alcohol use, withdrawal from friends and family, and reckless behaviour. Other signs may be more subtle, such as feelings of strong connections to individuals or a sense of cultural identity. Knowing these risk factors and warning signs can help prevent suicide.
If you or someone you love is experiencing suicidal thoughts or tendencies, you can immediately call the National Suicide Prevention Hotline at 1-800-273-8255 or the 988 Suicide and Crisis Lifeline at 988. These services are confidential, free, and available 24/7. You can also visit their website at 988lifeline.org to chat. If you are in a life-threatening situation, call 911.
In addition to hotlines and websites, there are also clinical trials and research studies that offer new ways to prevent, detect, and treat suicide. You can learn more about these studies and find one in your area by visiting the Substance Abuse and Mental Health Services Administration website or Clinicaltrials.gov.
Suicide prevention requires strategies at all levels of society, including individuals, families, and communities. By learning the warning signs, promoting prevention and resilience, and committing to social change, we can all help prevent suicide.
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Frequently asked questions
Please do not think about taking your own life. If you or someone you know is experiencing suicidal thoughts or tendencies, immediately call the National Suicide Prevention Hotline at 1-800-273-8255.
Physical signs of a sleeping pill overdose include extreme lethargy, abdominal pain, troubled breathing, and clumsiness.
If the victim appears to be gasping for air or has lost consciousness, administer CPR and call 911 immediately.
Some common sleeping pills include Ambien, Lunesta, and Rozerem. Additionally, certain benzodiazepine sedatives and antidepressants have been known to aid sleep but may cause dependence.

