
Sleep is divided into four stages, three of which are non-rapid eye movement (NREM) sleep stages, and the fourth is rapid eye movement (REM) sleep. During the NREM stages, the body relaxes, and muscle tone gradually decreases. However, during REM sleep, most muscles become temporarily paralysed, a condition known as atonia. This sudden drop in muscle tone occurs within a time window of no longer than two seconds. This temporary paralysis may help protect us from acting out our dreams, which tend to be the most vivid during this stage.
| Characteristics | Values |
|---|---|
| Muscle Tone During Sleep | Decreases during N3 sleep |
| Sudden drop during the transition from NREM to REM sleep | |
| Loss of muscle tone during REM sleep is one of the three signs to identify REM sleep | |
| Most muscles are paralyzed during REM sleep | |
| REM sleep muscle paralysis is caused by two powerful brain chemical systems | |
| REM sleep muscle paralysis is caused by the neurotransmitters gamma-aminobutyric acid (GABA) and glycine | |
| REM behavior disorder is caused by abnormal muscle tone during REM sleep |
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What You'll Learn

Muscle tone decreases during deep sleep
Sleep is a complex process that involves four to five sleep cycles, each composed of four stages. During a typical sleep cycle, an individual progresses through stages 1 to 3 of non-rapid eye movement (NREM) sleep before entering the final stage of rapid-eye movement (REM) sleep.
The first stage, N1, is the lightest stage of sleep and occurs as a person first falls asleep. In the second stage, N2, the body enters a more relaxed state, with a drop in body temperature, heart rate, breathing, and muscle relaxation.
Stage 3, or N3, is deep sleep, and it is harder to wake someone up during this phase. This stage is critical for restorative sleep, allowing the body to recover and grow. During N3 sleep, muscle tone, pulse, and breathing rate decrease further, and brain activity slows down significantly, exhibiting a pattern of delta waves.
During the REM stage, most muscles are paralyzed, a condition known as atonia, which prevents the body from acting out dreams. However, the eyes and muscles that control breathing remain active, resulting in rapid eye movement, giving this stage its name. While the exact reason for muscle paralysis during REM sleep is unknown, research suggests the involvement of neurotransmitters and brain chemical systems in inhibiting muscle activity.
Thus, muscle tone decreases during deep sleep (Stage 3) and remains low during REM sleep, when most muscles become temporarily paralyzed.
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REM sleep is characterised by muscle paralysis
Sleep is divided into several stages, each with different characteristics. During REM (rapid eye movement) sleep, brain activity increases, resembling wakefulness in many ways. However, the body experiences muscle atonia or paralysis, which is considered a normal function of REM sleep. This temporary paralysis is believed to protect us from acting out our dreams.
The exact mechanisms behind this muscle paralysis are not fully understood, but it is believed to be regulated by multiple transmitter systems, including GABA and glycine neurotransmitters. The suppression of muscle tone is a protective measure, as it prevents us from physically reacting to our dreams. Without this paralysis, individuals might act out their dreams, which could result in injury to themselves or their bed partner.
REM sleep behaviour disorder (RBD) is a condition where individuals exhibit abnormal muscle activity during REM sleep. Instead of the usual paralysis, individuals with RBD may experience increased muscle tone, allowing them to move and act out their dreams. These movements can range from minor twitches to complex behaviours. RBD is often diagnosed through careful evaluation and confirmed with a sleep study, which helps to rule out other sleep disorders and identify abnormal muscle tone.
The occurrence of muscle paralysis during REM sleep serves as a protective mechanism, ensuring that individuals remain relatively immobile while dreaming. This temporary loss of muscle tone is a normal and essential aspect of sleep, contributing to overall health and well-being.
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The transition from NREM to REM sleep causes a sudden drop in muscle tone
Sleep is divided into four stages, three of which are non-rapid eye movement (NREM) sleep stages, and the fourth is the rapid eye movement (REM) sleep stage. During NREM sleep, the body relaxes and the breathing and heart rates slow down. In the REM sleep stage, brain activity increases, and the body experiences atonia, which is a temporary paralysis of the muscles.
The transition from NREM sleep to REM sleep causes a sudden drop in muscle tone. This loss of muscle tone occurs within a time window lasting no longer than 2 seconds. This sudden drop in muscle tone is one of the three electrophysiological signs for identifying REM sleep, the other two being low voltage mixed-frequency EEG activity and episodic rapid eye movements. However, the latter two are inadequate for delimiting the start of REM sleep, as EEG activity is similar to that of stage 1, and rapid eye movements are not constantly present.
The sudden drop in muscle tone during the transition from NREM to REM sleep is caused by two powerful brain chemical systems that work together to paralyze skeletal muscles. Specifically, the neurotransmitters gamma-aminobutyric acid (GABA) and glycine cause REM sleep paralysis by "switching off" the specialized cells in the brain that allow muscles to be active. This discovery reversed the previously held belief that glycine was the lone inhibitor of these motor neurons.
The loss of muscle tone during REM sleep is considered a normal function and is important for preventing injury. REM sleep behaviour disorder occurs when the body maintains relatively increased muscle tone during REM sleep, allowing the sleeper to move and act out their dreams. This can result in minor movements such as leg twitches, but can also lead to very complex behaviour that may cause serious injury to the individual or their bed partner.
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Brain activity and muscle relaxation increase during non-REM sleep
Sleep is a complex process that involves the interplay of various physiological mechanisms. During sleep, the body undergoes distinct changes that enable rest and recovery, which are essential for overall health and well-being. The sleep cycle consists of two primary phases: rapid eye movement (REM) sleep and non-rapid eye movement (non-REM) sleep. Each cycle typically lasts between 70 and 120 minutes, and a person experiences four to five cycles per night.
Non-REM sleep can be further divided into three stages, each with unique characteristics and brain activity patterns. During the first stage of non-REM sleep, the body transitions from wakefulness to sleep. This stage is marked by slowing heart rate, breathing, and eye movements, along with muscle relaxation and occasional twitches. Brain waves also begin to slow down from their daytime patterns.
The second stage of non-REM sleep is a period of light sleep before entering deeper slumber. During this stage, the body temperature drops, and muscles relax even further. Heartbeat and breathing continue to slow down, preparing the body for the deeper sleep stages.
The third stage of non-REM sleep is the deepest and most restorative phase, crucial for bodily recovery and growth. During this stage, muscle tone, pulse, and breathing rate decrease significantly, and brain activity exhibits a distinct pattern known as delta waves. It is challenging to wake someone during this stage, and it plays a vital role in strengthening the immune system and other essential bodily functions.
While non-REM sleep is associated with muscle relaxation and decreased muscle tone, the transition to REM sleep brings about a sudden drop in muscle tone. During REM sleep, most muscles become temporarily paralysed, a state called atonia, preventing individuals from acting out their dreams. However, the eyes and muscles that control breathing remain active.
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REM sleep behaviour disorder is associated with abnormal muscle tone
Sleep is divided into four stages, the first three being non-REM sleep and the fourth being REM sleep. During non-REM sleep, the body relaxes, the heart rate and breathing slow, and the body temperature drops. During REM sleep, the body experiences a temporary paralysis of the muscles, except for the eyes and the muscles that control breathing. This paralysis is called atonia.
During REM sleep, brain activity is high, and most dreaming occurs. The eyes move rapidly behind closed eyelids, giving this stage its name: rapid eye movement sleep.
REM sleep behaviour disorder (RBD) is a sleep disorder in which the body does not enter a state of paralysis during REM sleep. Instead, the body maintains relatively increased muscle tone, allowing the sleeper to move and act out their dreams. These movements can be minor, such as leg twitches, or more complex, such as flailing, kicking, or even leaving the bed. These actions can cause injury to the individual or their bed partner, especially if they are acting out a violent dream.
RBD is considered rare, affecting about 1% of the general US population and 2% of people aged 50 or older. However, it can be challenging to diagnose, and almost half of those with the condition may be unaware they have it. RBD is strongly associated with certain neurodegenerative disorders. For example, research indicates that 97% of people with isolated RBD will develop Parkinson's disease, Lewy body dementia, or multiple system atrophy within 14 years of their RBD diagnosis.
The cause of RBD is not fully understood, but one theory suggests that it may be related to an issue in the brainstem, specifically in the pons, which is responsible for controlling muscle paralysis during REM sleep. Lesions in the pons are associated with Parkinson's disease and other neurodegenerative disorders linked to RBD. Researchers also believe that certain antidepressants can induce RBD due to imbalances in dopamine and serotonin, which play a role in regulating REM sleep.
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Frequently asked questions
The first stage of sleep, N1, is the lightest stage and occurs as a person first falls asleep.
During sleep, muscle tone decreases in N3 sleep, and during REM sleep, most muscles are paralysed.
REM sleep is the fourth stage of sleep and is best known for its association with vivid dreaming. It is characterised by increased brain activity, limited muscle movement, darting eye movement, and fluctuating respiration and heart rate.
During the first three stages of sleep, which are non-REM, the body and brain slow down. During Stage 2, the body enters a more subdued state where body temperature drops, muscles relax, and heart rate and breathing slow. Stage 3 is deep sleep, where the body is in recovery mode, slowing down even further.











































