
Neuroscientist and tenured professor in the Department of Neurobiology at the Stanford University School of Medicine, Andrew Huberman, has gained popularity for his podcast, Huberman Lab, where he discusses science-based tools for everyday life. In his podcast, Huberman talks about his sleep cocktail, a combination of three or four pills designed to help people fall asleep. The cocktail includes magnesium threonate or bisglycinate, L-theanine, apigenin, and inositol. Huberman himself suggests that people should start with one supplement and then add others as needed.
| Characteristics | Values |
|---|---|
| Number of Pills | 3 or 4 |
| Ingredients | Magnesium Threonate or bisglycinate, L-theanine, apigenin, and inositol |
| Magnesium Threonate Dosage | 200-400mg 2-3 hours before sleep |
| L-Theanine Dosage | 200mg |
| Apigenin Dosage | 50mg |
| Inositol Dosage | 900mg |
| Product Availability | Sold as a bundle or individual supplements |
| Product Format | Pills |
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What You'll Learn

Magnesium Threonate or bisglycinate
Magnesium is a robust mineral that can enhance sleep and decrease anxiety. Magnesium threonate and magnesium bisglycinate are two of the most effective forms of magnesium for sleep.
Magnesium threonate is a supplement that combines magnesium with L-threonate. It is designed to have a high absorption rate and the ability to penetrate the blood-brain barrier, which is why it is often used to improve cognitive function, mood, and sleep. Research has shown that magnesium threonate can have a calming and relaxing effect on the brain, making it easier to fall and stay asleep. It is also known for influencing brain function and improving memory, learning, attention, and focus. However, it is important to note that magnesium threonate may cause stomach issues in some individuals.
On the other hand, magnesium bisglycinate is formed by combining magnesium with the amino acid glycine, which has calming properties. This supplement is highly bioavailable, meaning it is easily absorbed by the body, specifically through the small intestine. Magnesium bisglycinate is commonly used to treat magnesium deficiency and is often favoured for improving sleep quality due to its soothing effects and superior absorption. It is also more budget-friendly than magnesium threonate.
Both magnesium threonate and magnesium bisglycinate are safe and effective options for increasing magnesium intake and improving sleep. They can be taken together as they target different health areas and offer complementary benefits. However, it is important to consult with a healthcare professional to determine the appropriate dosage and ensure safety.
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L-theanine
In the Huberman Sleep Cocktail, the recommended dosage of L-theanine is 200mg. The supplement also includes rice flour, hypromellose (capsule), magnesium stearate, and silica.
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Apigenin
It is important to note that apigenin can also act as an estrogen inhibitor. While this may be beneficial for some individuals, it is essential to consult with a healthcare professional before taking any supplements, especially if you have any health concerns or are taking medication.
Andrew Huberman himself suggests that individuals should start with one supplement (or none) and then add one at a time as needed. This allows people to determine what works best for them. He emphasizes that the key to sleep and sleep supplements is to alleviate anxiety and relax overactive brain activity.
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Inositol
In the Huberman Sleep Cocktail, inositol helps regulate mood and nighttime wakeups. It is thought to work synergistically with the other ingredients in the cocktail to calm the nervous system, regulate neurotransmitters, and help ease the mind into a restorative sleep cycle.
The official Huberman Sleep Cocktail sells all four products as a bundle. However, Huberman himself suggests that people shouldn't take all the supplements right away. Instead, he recommends starting with one supplement and adding the others as needed. He also notes that some people may not need any supplements at all.
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Sleep is the best nootropic, stress relief, trauma release, immune booster, hormone augmentation, and emotional stabiliser
Sleep is the cornerstone of health and well-being, and its importance cannot be overstated. Dr. Andrew Huberman, a renowned neuroscientist and professor at Stanford University, has described sleep as "the best nootropic, the best stress relief, the best trauma release, the best immune booster, the best hormone augmentation, and the best emotional stabiliser". Through his popular podcast and research, Dr. Huberman has emphasised the critical role of sleep in maintaining optimal health and enhancing various aspects of our lives.
Firstly, sleep is the ultimate nootropic, enhancing our cognitive abilities and brain function. A good night's sleep improves our focus, memory, and creativity, providing us with the mental clarity and sharpness to tackle the day's challenges. Sleep also serves as the best stress relief mechanism. It is during sleep that our bodies recover from the stresses of daily life, reducing the negative impacts of stress on our physical and mental health. Sleep allows us to reset and approach the next day with renewed vigour and resilience.
Additionally, sleep is a powerful tool for trauma release. As we sleep, our brains process and integrate our daily experiences, helping us cope with traumatic events and promoting emotional healing. Sleep also boosts our immune system, strengthening our body's defences against illnesses and infections. It plays a vital role in regulating our hormones, ensuring the optimal functioning of our reproductive, metabolic, and other physiological systems. Sleep further acts as an emotional stabiliser, influencing our mood and emotional well-being. A good night's sleep can improve our mood, enhance our emotional resilience, and help us manage our emotions effectively.
Dr. Huberman's perspective on sleep is supported by his research and the experiences of his followers. His "Sleep Cocktail" and "Complete Sleep Stack" have gained popularity as science-based tools to improve sleep quality. These involve the use of supplements such as magnesium, L-theanine, apigenin, and inositol, which work synergistically to calm the nervous system, regulate neurotransmitters, and promote restorative sleep. By addressing sleep issues and improving sleep quality, Dr. Huberman's methods have positively impacted the lives of many individuals seeking to optimise their health and well-being.
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Frequently asked questions
Andrew Huberman's sleep cocktail is a combination of three or four pills designed to help people fall asleep. The pills are a few of the many supplements Huberman takes. The sleep cocktail consists of magnesium threonate or bisglycinate, L-theanine, apigenin, and inositol.
Magnesium threonate has been thought to be a significant cognitive support supplement, with research suggesting its supplementation can play a role in mitigating conditions like headaches and stress. Apigenin is a natural compound found in certain plants, and research suggests that it has sleep-promoting properties. L-Theanine is an amino acid found naturally in green tea and promotes relaxation while maintaining alertness. Inositol is a carbohydrate found naturally in the body and certain foods and helps regulate mood and nighttime wakeups.
Andrew Huberman has said that sleep is the "best nootropic, the best stress relief, the best trauma release, the best immune booster, the best hormone augmentation, and the best emotional stabilizer." He also said that "people who are strictly nocturnal do far worse on immune function, metabolic function, etc. than people who are diurnal."










































