
Saphris (asenapine) is a medication used to treat schizophrenia and bipolar disorder in adults. It is an antipsychotic medication that works by regulating certain chemicals in the brain that control mood, thoughts, and behaviour. While it is not typically recommended for anxiety disorders, it may be prescribed off-label for other conditions. Saphris can cause side effects such as drowsiness, dizziness, and high blood sugar, which may lead to increased thirst, hunger, and blurred vision. It is important to consult a doctor before taking Saphris, especially when considering its use for sleep, as combining it with other medications that cause drowsiness can be dangerous.
| Characteristics | Values |
|---|---|
| What is Saphris used for? | Saphris is used to treat symptoms of schizophrenia and bipolar disorder (mania or mixed episodes, but not depression) in adults. |
| How does it work? | By restoring balance to certain neurotransmitters in the brain, such as serotonin and dopamine, which are known to affect thoughts and mood. |
| Who should not use it? | People with severe liver disease or reduced liver function, older adults with dementia-related psychosis, pregnant women (especially in the last 3 months of pregnancy), breastfeeding women, and people who are allergic to asenapine. |
| What are the side effects? | Drowsiness, dizziness, changes in appetite, high blood sugar, muscle/nervous system problems, high body temperature, low blood pressure, increased risk of blood clots, and serious movement disorders with long-term use or high doses. |
| Interactions | Alcohol, alpha-blockers, anticholinergics, antibiotics, antihistamines, antidepressants, drugs for sleep or anxiety, muscle relaxants, narcotics, and other medications that cause drowsiness. |
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What You'll Learn

Saphris is not a sleep medication
Saphris is a medication used to treat schizophrenia and bipolar disorder in adults. It is also used to treat symptoms of psychotic disorders such as mania and bipolar disorder. It is not a medication for sleep.
Saphris, or asenapine, is an antipsychotic medication that belongs to a group of medicines called second-generation (atypical) antipsychotics. It works by modulating certain neurotransmitters in the brain, such as dopamine and serotonin, which are known to affect thoughts and mood. It is available as a sublingual tablet that dissolves under the tongue.
While Saphris may cause mild drowsiness as a side effect, it is not a medication specifically designed or approved for inducing sleep. It is important to note that Saphris interacts with other medications that cause drowsiness, such as antidepressants, sleeping pills, anxiety medications, and alcohol. Combining Saphris with these substances can lead to additive drowsiness, which can be dangerous. Therefore, it is crucial to consult with a healthcare professional before taking Saphris and to avoid using it solely as a sleep aid.
Additionally, Saphris has some serious side effects that should be considered. It can cause high blood sugar (hyperglycemia), which may result in increased thirst, urination, hunger, dry mouth, fruity breath odour, drowsiness, dry skin, and blurred vision. It can also lead to severe neurological problems, including uncontrolled muscle movements, low white blood cell counts, and a severe nervous system reaction characterized by rigid muscles, high fever, sweating, confusion, and irregular heartbeats. Furthermore, Saphris may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.
In conclusion, while Saphris may cause drowsiness in some individuals, it is not a sleep medication. It is a prescription antipsychotic drug used to treat specific mental health disorders. Anyone considering Saphris should consult a healthcare professional to weigh the risks and benefits and determine if it is an appropriate treatment for their specific condition.
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It is an antipsychotic medication
Saphris (asenapine) is an antipsychotic medication used to treat schizophrenia and bipolar disorder in adults. It is also used to treat symptoms of psychotic disorders such as mania and bipolar disorder. It belongs to the class of atypical antipsychotics, which work by modulating certain neurotransmitters in the brain, such as dopamine and serotonin. These chemicals are known to affect thoughts and mood. By restoring balance to these neurotransmitters, Saphris helps manage symptoms like hallucinations, delusions, and mood swings.
Saphris is typically taken twice daily, with a dose ranging from 2.5 mg to 10 mg per day. It is available as a sublingual tablet, which means it is placed under the tongue and allowed to dissolve without chewing. It should not be swallowed. It is important to follow the directions provided by a healthcare professional when taking Saphris.
As an antipsychotic medication, Saphris may cause side effects such as muscle/nervous system problems (extrapyramidal symptoms), high blood sugar (hyperglycemia), and an increased risk of death in older adults with dementia-related psychosis. It can also cause drowsiness, dizziness, and changes in appetite. It is important to discuss any side effects with a healthcare provider.
Saphris may interact with other medications, such as alpha-blockers, anticholinergic/antispasmodic drugs, antibiotics, alcohol, and antihistamines. It is important to inform your doctor of any medications you are currently taking before starting Saphris. Additionally, Saphris should be used with caution in individuals with liver problems or heart disease, as it may affect liver function and cause low blood pressure.
While Saphris is primarily used to treat schizophrenia and bipolar disorder, healthcare providers may prescribe it off-label for other conditions. Some off-label uses of Saphris include the treatment of post-traumatic stress disorder, catatonia, cocaine-induced psychotic disorder, and borderline personality disorder.
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It is used to treat schizophrenia and bipolar disorder
Saphris (asenapine) is a second-generation atypical antipsychotic medication used to treat schizophrenia and bipolar disorder in adults. It is thought to work by balancing brain chemicals called serotonin and dopamine, which are known to affect thoughts and mood. These chemicals are also known as neurotransmitters and are often associated with conditions like schizophrenia and bipolar disorder. Bipolar disorder, for example, causes alternating periods of depression and mania (elevated or irritable mood) or "mixed episodes" where symptoms of both occur simultaneously.
Schizophrenia and bipolar disorder are mental health conditions that can cause symptoms such as hallucinations, delusions, and mood swings. Saphris is used to manage these symptoms by restoring balance to the aforementioned neurotransmitters in the brain. It is available as a sublingual tablet, which is placed under the tongue and allowed to dissolve without chewing. The usual dose is 5 to 10 mg taken twice daily, although the dosage is individualised to the patient's needs and response to treatment.
Saphris is not suitable for everyone and should not be taken if you have severe liver disease or reduced liver function. It may also cause serious neurologic problems, high blood sugar, and low blood pressure, especially when moving from a lying or sitting position to a standing one. It can also increase the risk of death in older adults with dementia-related psychosis and should only be used during pregnancy when prescribed by a doctor.
It is important to discuss with your healthcare provider whether Saphris is suitable for you based on your medical history, symptoms, and potential side effects.
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It should not be used with alcohol or sleep medication
Saphris (asenapine) is a medication used to treat schizophrenia and bipolar disorder in adults. It is also used to treat symptoms of psychotic disorders, such as mania or bipolar disorder. It belongs to a group of medicines called second-generation (atypical) antipsychotics, which work by balancing brain chemicals called serotonin and dopamine. These chemicals are known to affect thoughts, mood, and behavior.
While Saphris can be an effective treatment for these conditions, it is important to note that it should not be used with alcohol or sleep medication. Combining Saphris with alcohol or sleep medication can lead to dangerous side effects. Both alcohol and sleep medications are central nervous system (CNS) depressants, which act as sedatives and can make you drowsy or less alert. When combined with Saphris, the effects of these depressants are enhanced, leading to an increased risk of additive drowsiness, dizziness, lightheadedness, and fainting. This can be especially dangerous if it impairs your ability to drive, use machinery, or perform other activities that require alertness and coordination.
Additionally, consuming alcohol while taking Saphris can increase your risk of other side effects, such as sleepiness, dizziness, lightheadedness, or fainting upon standing. It is crucial to be aware of these potential risks and avoid consuming alcohol or taking sleep medications while using Saphris. If you are currently taking any sleep medications or medications that cause drowsiness, be sure to inform your doctor before starting Saphris.
It is also important to note that Saphris may not be suitable for everyone. It is not recommended for individuals with severe liver disease or reduced liver function. If you have liver problems, it is essential to discuss with your doctor how Saphris may affect your condition and whether it is safe for you to take this medication. Furthermore, Saphris should be used with caution in older adults with dementia-related psychosis as it may increase the risk of death in this population.
In conclusion, while Saphris can be a beneficial treatment for schizophrenia and bipolar disorder, it is crucial to follow the instructions provided by your healthcare provider and avoid using it in conjunction with alcohol or sleep medication. Always consult your doctor or healthcare provider before starting or stopping any medication to ensure your safety and well-being.
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It can cause drowsiness
Saphris (asenapine) is a medication that can cause drowsiness. It is important to note that this medication should not be combined with alcohol or other medications that can cause drowsiness, such as antidepressants, sleeping pills, antihistamines, and anxiety medications. The additive effects of these substances can lead to dangerous levels of drowsiness.
Drowsiness is a common side effect of Saphris, also known by its generic name, asenapine. It is a second-generation (atypical) antipsychotic medication that is used to treat mental health conditions, particularly schizophrenia and bipolar disorder. The recommended dose for adults is 5 to 10 mg taken twice daily, and it is important to follow the directions on the prescription label.
The medication works by modulating certain neurotransmitters in the brain, such as dopamine and serotonin, which are known to affect thoughts and mood. By restoring balance to these neurotransmitters, Saphris helps manage symptoms such as hallucinations, delusions, and mood swings associated with schizophrenia and bipolar disorder.
However, one of its side effects is mild drowsiness, which is often listed among the most common side effects of the medication. This drowsiness can be dangerous when combined with activities that require alertness, such as driving or operating machinery. Therefore, it is important to understand how Saphris affects your body before engaging in such activities. Additionally, Saphris may cause high blood sugar (hyperglycemia), which can lead to increased thirst, increased urination, hunger, dry mouth, fruity breath odour, dry skin, and blurred vision.
Furthermore, combining Saphris with alcohol or other medications that cause drowsiness can be dangerous. Alcohol is a central nervous system (CNS) depressant, and when combined with Saphris, it can enhance the drowsiness effect. Similarly, other CNS depressants, such as antihistamines, allergy or cold medicines, sedatives, tranquilizers, sleeping medicines, prescription pain medicines, muscle relaxants, and dental anesthetics, can have additive effects when taken with Saphris. Therefore, it is crucial to consult with a doctor or pharmacist before taking Saphris to ensure safe and effective use.
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Frequently asked questions
Saphris (asenapine) is a medication used to treat schizophrenia and bipolar disorder in adults. It is also used to treat symptoms of psychotic disorders such as mania.
The most common side effects of Saphris include drowsiness, dizziness, changes in appetite, high blood sugar, muscle/nervous system problems, and low blood pressure.
While Saphris may cause drowsiness as a side effect, it is not primarily used as a sleep aid. Combining it with alcohol or other medications that cause drowsiness can be dangerous.










































