
While Benadryl can help people fall asleep, it is not recommended to take it for sleep. Benadryl's active ingredient, diphenhydramine, is an antihistamine that affects the body's natural sleep-wake cycle, making it easier to fall asleep. However, studies have shown that Benadryl does not improve sleep quality and may even decrease it. Additionally, Benadryl can cause side effects such as nervousness, dry mouth, dizziness, and headaches. It is important to note that Benadryl should not be used for more than two weeks at a time and is not suitable for long-term use. If you are experiencing insomnia or other sleep issues, it is recommended to consult a healthcare professional.
| Characteristics | Values |
|---|---|
| Recommended dosage for sleep | 50 mg taken orally 30 minutes before bedtime for adults and children over 12 years old |
| Dosage alternatives | 25 mg |
| Maximum duration | Two weeks (14 days) |
| Side effects | Nervousness, dry nose, mouth and throat, dizziness, headache, nausea, loss of appetite, sleepwalking, parasomnias, hyperactivity, slowed reaction time, cognitive impairment, dependence |
| Risk factors | Elderly people, pregnant or nursing people, people with liver or kidney disease |
| Effectiveness | May not improve sleep quality, may decrease sleep quality, may lose effectiveness over time |
| Interactions | Check for multiple medications containing diphenhydramine, including Tylenol PM Extra Strength, Advil PM, Excedrin PM, Motrin PM |
| Precautions | Consult a doctor or pharmacist before use, especially for children, elderly people, and pregnant or nursing people |
| Alternatives | Melatonin, Rozerem (ramelteon), Silenor (doxepin), Halcion (triazolam), Ambien (zolpidem), Restoril (temazepam), good sleep hygiene, cognitive behavioral therapy |
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What You'll Learn

Benadryl is an antihistamine that can make you drowsy
Benadryl is an antihistamine drug that contains diphenhydramine, which is known to cause drowsiness. Histamine, a molecule naturally produced by the body, helps keep people awake during the day. Antihistamines block the effect of histamine, leading to sleepiness. This is why Benadryl is often used as a sleep aid.
However, while Benadryl can help people fall asleep, it may not improve sleep quality. Research suggests that Benadryl may even decrease sleep quality, causing daytime sleepiness that persists after waking up. This is because Benadryl can slow down the brain's responses, affecting motor skills and reaction time. Benadryl may also lead to other side effects, including nervousness, dry nose, mouth and throat, dizziness, headache, nausea, and loss of appetite.
The use of Benadryl as a sleep aid is not recommended, especially for long-term use. People can develop a tolerance to Benadryl very quickly, and it may lose its effectiveness over time. Additionally, the risk of side effects increases with higher doses and long-term use, especially in older adults. Anticholinergic drugs like Benadryl can cause cognitive impairment and increase the risk for dementia and Alzheimer's disease.
It is important to consult a healthcare professional before using Benadryl or any antihistamine as a sleep aid, especially if taken regularly or for extended periods. There are alternative sleep aids, such as melatonin, that may be safer and more effective in improving sleep quality.
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Benadryl may not improve sleep quality
While Benadryl may help people fall asleep, it may not improve sleep quality. Benadryl's active ingredient, diphenhydramine, is an antihistamine that affects the body's natural sleep-wake cycle, making people feel drowsy. However, studies have not found evidence that Benadryl improves sleep quality, and it may even decrease it.
The use of medication to induce sleep is generally not recommended, especially for children. Benadryl can cause side effects such as nervousness, dry mouth, dizziness, headache, nausea, and loss of appetite. It can also lead to parasomnias like sleepwalking and slowed reaction times, which can persist into the following day. Additionally, the more someone takes Benadryl to sleep, the less effective it becomes, with one study showing that it became no more effective than a placebo after four days.
Benadryl is not well-suited for long-term use. It is typically not a go-to medication for chronic insomnia, and it is recommended that people taking it consistently for two weeks or more consult a healthcare professional. Long-term use of antihistamines like Benadryl may increase the risk of dementia and Alzheimer's disease and can cause cognitive impairment that persists even after stopping the medication.
Instead of relying on Benadryl for sleep, individuals can try alternative sleep aids like melatonin, good sleep hygiene, and cognitive behavioural therapy. If insomnia persists, it is advisable to consult a healthcare professional, as it could be a symptom of an underlying medical condition.
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Benadryl is not recommended for long-term use
While Benadryl can help people fall asleep, it is not recommended for long-term use. Benadryl is not a go-to medication for chronic insomnia and should only be taken occasionally for sleep issues. This is because Benadryl does not improve the quality of sleep and may even decrease it. Research has shown that the more someone takes Benadryl to help them sleep, the less effective it becomes. In addition, Benadryl can cause side effects such as nervousness, dry nose, mouth and throat, dizziness, headache, nausea, and loss of appetite. These side effects can be dangerous, especially for older adults. For example, Benadryl can slow the brain's responses, affecting motor skills and reaction time, which can persist into the following day. Furthermore, a 2021 review of 14 studies found that taking anticholinergic medications like Benadryl increased the risk for dementia and Alzheimer's disease, and that higher exposure increased this risk.
Benadryl is also not recommended for long-term use because people can develop a tolerance to it very quickly. This means that the longer someone takes Benadryl, the less effective it will be at helping them fall asleep. Instead of relying on Benadryl, people with chronic insomnia should talk to a healthcare professional, who may prescribe alternative medications or recommend lifestyle changes such as improving sleep hygiene, cognitive behavioral therapy, or melatonin.
It is important to note that Benadryl is not the only sleep aid that poses risks. Many prescription sleep aids are not appropriate for everyone, especially those who are pregnant or have certain health conditions such as liver or kidney disease. Some prescription sleep aids may also cause unwanted side effects or dependence. Therefore, it is always a good idea to consult a healthcare professional before taking any sleep medication, including Benadryl, to ensure it is safe and appropriate for your individual needs.
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Benadryl can have side effects
While Benadryl can help people fall asleep, it may not be the best choice of a sleep aid due to its potential side effects. Firstly, Benadryl can cause reduced sleep quality, leading to daytime drowsiness and fatigue. Research suggests that it may even decrease sleep quality, resulting in a person feeling less rested upon waking up. Additionally, Benadryl can cause nervousness, dizziness, a dry nose, mouth, and throat, headaches, nausea, and loss of appetite. It can also slow down the brain's responses, affecting motor skills and reaction time, which can persist into the following day.
Benadryl is not recommended for long-term use, as it can lead to a loss of effectiveness over time. Studies have shown that the more frequently someone takes Benadryl to aid sleep, the less effective it becomes. In older adults, Benadryl is more likely to cause side effects, and its use is generally discouraged. Furthermore, long-term use of antihistamines like Benadryl may increase the risk for dementia and Alzheimer's disease in older individuals.
Benadryl can also cause altered mental states, urinary retention, and sleepwalking or other parasomnias, especially in the elderly. In children, Benadryl has been associated with serious side effects, and it may even cause hyperactivity instead of drowsiness. Therefore, parents and guardians should consult a doctor before administering Benadryl to children.
It is important to note that Benadryl may interact with other medications, so it is advisable to consult a healthcare professional or pharmacist before taking it for sleep. They can help determine if Benadryl is suitable for you and ensure it does not interact with your current medications. Overall, while Benadryl may help induce sleep, its side effects and potential risks should be carefully considered before using it as a sleep aid.
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Benadryl may not be suitable for children and older adults
Benadryl is an over-the-counter antihistamine medication that treats seasonal allergies, cold symptoms, and allergic reactions in children and adults. The active ingredient in Benadryl, diphenhydramine, blocks histamine, which is involved in keeping people awake during the day, leading to sleepiness. While Benadryl can help people fall asleep, doctors advise against overusing it for insomnia or other sleep issues, especially in older adults.
Benadryl is not recommended for children under 12 years old, and in some cases, healthcare providers may suggest avoiding it in younger children and older adults. The risk of side effects increases with age, and older adults are more likely to experience adverse effects. Benadryl is not a suitable long-term solution for chronic insomnia in adults and children over 12, as it can cause reduced sleep quality and loss of effectiveness over time.
Newer second-generation antihistamines, such as loratadine, cetirizine, and fexofenadine (Claritin®, Zyrtec®, and Allegra®), are preferred for children. These medications are faster-acting, longer-lasting, and have fewer side effects than Benadryl. Similarly, for older adults, it is essential to consult a healthcare professional before taking Benadryl, as there may be alternative treatments that are safer and more effective.
Overall, while Benadryl can be effective in inducing sleep, it may not be suitable for children and older adults due to the risk of side effects and the potential for reduced sleep quality. It is important to consult a healthcare professional to discuss alternative treatments and address any underlying causes of sleep issues.
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Frequently asked questions
No, you should only take one Benadryl product at a time. The recommended dosage for sleep is 50 mg by mouth 30 minutes before bedtime for adults and kids over 12 years old. Taking too much Benadryl increases the risk of side effects and it's not recommended for long-term use.
Side effects of taking Benadryl include nervousness, dry nose, mouth and throat, dizziness, headache, nausea, and loss of appetite. Benadryl can also cause sleepwalking and other parasomnias, especially in older adults. It can also slow reaction time and affect motor skills, which can persist into the following day.
Yes, alternatives to Benadryl include Rozerem (ramelteon), Silenor (doxepin), Halcion (triazolam), Ambien (zolpidem), and Restoril (temazepam). It's recommended to consult a healthcare professional to discuss alternatives, especially if you are experiencing chronic insomnia.


























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