
Orajel is a topical anesthetic that contains benzocaine and is used to relieve pain from minor mouth problems such as toothaches, canker sores, and sore gums. It is recommended that you wait at least an hour before consuming anything after using Orajel. It is also advised to avoid eating within an hour of using Orajel and to avoid swallowing the gel. Since Orajel may cause side effects such as slowed breathing or respiratory failure, it is important to consider these factors when deciding whether to sleep after using the product. While it is generally recommended to follow the instructions and warnings on the package, consulting a doctor or pharmacist is the best way to determine if it is safe to sleep after using Orajel.
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What You'll Learn

Orajel overdose can be life-threatening
Orajel is a topical treatment for the mouth and gums that may be used to relieve pain associated with minor mouth problems. Medicated formulations of Orajel contain benzocaine, a local anesthetic that works by blocking nerve signals in the body to numb the skin or surfaces inside the mouth. Nonmedicated formulations of Orajel do not contain benzocaine and are marketed for use during teething.
The use of topical benzocaine has also been associated with methemoglobinemia, a rare but serious and potentially fatal condition that affects how red blood cells deliver oxygen around the body. People who develop methemoglobinemia may experience pale, gray, or blue-colored skin, lips, and nail beds; shortness of breath; fatigue; confusion; headache; lightheadedness; and rapid heart rate. Symptoms of methemoglobinemia may occur within minutes to 1 to 2 hours of using benzocaine and may appear the first time or after many uses. If any symptoms of methemoglobinemia occur, the person should receive medical attention immediately.
It is important to follow all directions on the Orajel product package and use the smallest amount needed, even in adults and older children. Do not use more than the recommended dose, and do not use this medicine more than four times a day unless directed by a doctor. Orajel should not be used in children under the age of 2 due to the risk of serious side effects, including methemoglobinemia.
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Methemoglobinemia: a rare but fatal blood disorder
Orajel is a medication that contains benzocaine, a local anaesthetic that numbs the skin or surfaces inside the mouth to relieve pain. Although rare, Orajel has been associated with methemoglobinemia, a potentially fatal blood disorder.
Methemoglobinemia is an uncommon condition that results from exposure to certain chemicals or medications, affecting how red blood cells deliver oxygen around the body. In other words, it is a condition in which the amount of oxygen carried through the blood is greatly reduced. This reduction in oxygen levels can be dangerous, and even fatal.
The symptoms of methemoglobinemia include pale, grey, or blue-coloured skin, lips, and nail beds, as well as shortness of breath, fatigue, headache, lightheadedness, and a rapid heart rate. These symptoms may occur within minutes to a couple of hours after using Orajel and can appear the first time the medication is used or after multiple uses. If any of these symptoms occur, medical attention should be sought immediately.
The use of topical benzocaine, the active ingredient in Orajel, has been linked to methemoglobinemia. As a result, the FDA has issued warnings about the use of benzocaine products, especially in children under the age of 2, and advised that a standardised methemoglobinemia warning be included in the prescribing information of all prescription local anaesthetics.
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Orajel is not recommended for children under 2
Orajel is a topical anaesthetic that can be used to numb pain or discomfort in the mouth or elsewhere in the body. It is available in medicated and non-medicated formulations. The medicated versions contain benzocaine, a local anaesthetic that works by blocking nerve signals in the body.
While Orajel is a useful medication for many, it is not recommended for children under 2. This is because the use of benzocaine has been associated with methemoglobinemia, a rare but potentially fatal condition. This condition affects how red blood cells deliver oxygen around the body, and symptoms include pale, grey, or blue-coloured skin, lips, and nail beds, as well as shortness of breath, fatigue, headache, lightheadedness, and rapid heart rate.
The FDA has stated that Orajel products containing benzocaine should not be used by children under the age of 2. While this condition can occur in anyone, the risk of serious side effects is higher in young children. Even non-medicated formulations, which do not contain benzocaine, are not recommended for children under 2 by the American Academy of Pediatrics (AAP) as they wash out of the baby's mouth within minutes and may present safety concerns if ingested.
If you are considering using Orajel for a child over the age of 2, it is important to note that it should only be used under the guidance of a doctor and with adult supervision. It is always best to consult with a healthcare professional before using any new medication, especially on children.
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Side effects: numbness, fatigue, headache, dizziness
Orajel is a topical anaesthetic that contains benzocaine, a numbing medication that works by blocking nerve signals in the body. It is used to relieve pain from minor mouth problems such as toothaches, canker sores, and sore gums. It is intended for use by adults and children over the age of 12.
While Orajel can be effective at relieving pain, it is important to be aware of its potential side effects, which can become serious if large amounts are used. One of the most concerning side effects is methemoglobinemia, a rare but potentially fatal blood disorder that affects how red blood cells deliver oxygen around the body. Symptoms of methemoglobinemia include pale, gray, or blue-colored skin, lips, and nail beds; shortness of breath; fatigue; headache; dizziness; lightheadedness; unusual tiredness; and a rapid heart rate. These symptoms may occur within minutes to a couple of hours of using Orajel and require immediate medical attention.
In addition to the risk of methemoglobinemia, other side effects of Orajel include numbness, slight burning, tingling, or stinging at the application site. It is important to wash your hands after applying Orajel to avoid accidentally absorbing too much of the product, which can increase the risk of side effects.
While Orajel can be safely used to treat pain and discomfort, it is always advisable to consult a doctor or pharmacist, especially if you have any health concerns or are using other medications.
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Precautions: heart and breathing conditions
Orajel is a topical treatment for the mouth and gums that may be used to relieve pain associated with minor mouth problems. It is available as a medicated or non-medicated formulation. Medicated formulations of Orajel contain benzocaine and are intended for use by adults and children over the age of 12. They can be used by children aged 2 to 12 years if under the guidance of a doctor and an adult supervising the amount used.
Benzocaine is a local anesthetic (numbing medication) that works by blocking nerve signals in your body. The use of topical benzocaine has been associated with methemoglobinemia, a rare but potentially fatal blood disorder that affects how red blood cells deliver oxygen around your body. This condition may cause a rapid heart rate and shortness of breath, among other symptoms. If you have any heart disease or breathing problems such as asthma, bronchitis, or emphysema, you should consult your doctor or pharmacist before using Orajel. This is because having heart or lung issues increases your risk of developing a negative reaction to the medication and makes you more likely to experience side effects.
If you have any of the following health problems, it is important to consult your doctor or pharmacist before using Orajel: certain blood disorders (G6PD deficiency, pyruvate kinase deficiency, hemoglobin-M disease, NADH-methemoglobin reductase deficiency), breathing problems (such as asthma, bronchitis, emphysema, smoking history), or heart disease. It is also important to note that an overdose of benzocaine can cause fatal side effects if too much of the medicine is absorbed through the skin and into the bloodstream. Symptoms of an overdose may include slow or shallow breathing, irregular heartbeat, seizures, and loss of consciousness.
If you experience any signs or symptoms of methemoglobinemia, seek emergency medical attention immediately. These symptoms include pale, gray, or blue-colored skin, lips, and nail beds; shortness of breath; fatigue; headache; lightheadedness; or a rapid heart rate. Methemoglobinemia is a serious condition that can occur within minutes to a couple of hours of using Orajel and may be life-threatening.
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Frequently asked questions
It is advised to wait at least one hour before consuming anything after using Orajel. It is best to consult your doctor if you have any concerns.
Orajel is a topical anesthetic that can be used to relieve pain or discomfort in the mouth or body. It can be used to treat toothaches, canker sores, sore gums, and mouth injuries.
Yes, Orajel can cause slight burning, tingling, or stinging. In rare cases, it has been known to cause a serious and possibly fatal blood disorder called methemoglobinemia. Symptoms of this disorder include pale, blue, or gray skin, unusual tiredness, shortness of breath, and a rapid heart rate.
To apply Orajel, dab the product onto the affected area using slow and gentle movements. Continue dabbing until you have created a thin layer of Orajel. Wash your hands after applying to avoid accidentally absorbing too much of the product, which can increase your risk of side effects.











































