
Sleep aids and alcohol are both central nervous system depressants, meaning they slow brain activity. As such, mixing the two can be dangerous and even deadly. Alcohol increases the side effects and sedation associated with all sleep aids, whether over-the-counter or prescription. This can lead to excessive drowsiness, falls, confusion, difficulty concentrating, and impaired information processing. In rare cases, mixing valerian root or melatonin with alcohol may increase the risk of liver damage or breathing issues. To avoid these risks, it is recommended to wait until your body has completely cleared the alcohol from your system before taking any sleep aid.
| Characteristics | Values |
|---|---|
| Safety | Mixing alcohol and sleeping pills is dangerous and can even be deadly |
| Side effects | Excessive drowsiness, dizziness, confusion, difficulty concentrating, memory loss, sleepwalking, liver damage, increased risk of fractures, rapid heartbeat, weakness, mild shaking, flushed skin, sweating, headache, disorientation, hallucinations |
| Addiction | Alcohol use disorder is linked to sleep medication use |
| Treatment | Medical detox, rebound insomnia treatment, individual and group therapy, behavioural interventions |
| Alternatives | Relaxation therapy, sleep hygiene education, cognitive behavioural therapy, stimulus control, sleep restriction |
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What You'll Learn

Valerian root and alcohol
Valerian (Valeriana officinalis) is a herb native to Europe and parts of Asia. It is also found in North America. Valerian root has been used as a sedative and traditional medicine since ancient Greek and Roman times. It is a common ingredient in dietary supplements for sleep and anxiety.
Valerian root is generally considered safe for adults, but it is recommended to avoid combining it with alcohol. Alcohol can increase the nervous system side effects of valerian, such as dizziness, drowsiness, and difficulty concentrating. The combined effect may result in excessive sleepiness, confusion, impaired thinking, and judgment. In rare cases, this combination may increase the risk of liver damage. Therefore, it is advised to avoid or limit alcohol consumption when taking valerian root.
Additionally, valerian root should not be used with other sleep aids, antidepressants, or sedative drugs. It is also not recommended for women who are pregnant or nursing, as there is limited research on its safety during these periods.
If you are considering taking valerian root, it is always best to consult with your doctor or a healthcare professional to ensure its safe use and determine the appropriate dosage for your needs.
For insomnia or sleep troubles, the recommended dosage is 300 to 600 milligrams of valerian root taken 30 minutes to two hours before bedtime. It may take two or more weeks of regular use to notice improvements in sleep quality.
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Side effects of mixing sleep aids and alcohol
Mixing sleep aids and alcohol can have several side effects, ranging from mild to severe and even life-threatening. The specific side effects may depend on various factors, including the amount of alcohol consumed, the type of sleep aid taken, and the timing between consuming alcohol and taking the sleep aid. Here are some of the potential side effects:
Heightened Sedative Effects and Increased Risk of Overdose: Both alcohol and sleep aids have sedative properties. When combined, their sedative effects are enhanced, leading to excessive drowsiness and an increased risk of overdose. This heightened sedation can result in breathing problems, slowed heart rate, lowered blood pressure, impaired motor control, and even a coma-like state.
Memory Problems and Confusion: Mixing alcohol and sleep aids can lead to memory issues, including memory loss and difficulty concentrating. Confusion and impaired information processing are also common side effects of this combination.
Addiction and Withdrawal Issues: Regular or frequent use of both alcohol and sleep aids can increase the risk of developing an addiction to both substances. As a result, withdrawal from either or both substances becomes more complicated and severe, often requiring professional medical supervision.
Rebound Insomnia: When attempting to quit the use of alcohol and sleep aids, rebound insomnia is likely to occur. This means that individuals may experience even greater difficulty falling and staying asleep during the recovery process.
Increased Side Effects with Specific Sleep Aids: Certain sleep aids, such as valerian root, diphenhydramine (found in Benadryl, ZzzQuil, etc.), doxylamine (Unisom), and melatonin, when combined with alcohol, can lead to intensified side effects. These side effects may include dizziness, drowsiness, confusion, difficulty concentrating, and an increased risk of fractures. Additionally, mixing valerian root with alcohol may, in rare cases, increase the risk of liver damage.
It is important to note that even small amounts of alcohol can interact dangerously with sleep aids. Therefore, it is generally advised to avoid mixing alcohol with any type of sleep aid to prevent potentially harmful or fatal consequences.
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Treatment for addiction to alcohol and sleep aids
Mixing alcohol and sleep aids can have several dangerous side effects. Alcohol and sleeping pills are both central nervous system depressants, meaning they slow brain activity. When taken together, the negative effects of both substances are compounded, leading to potential health issues and even overdose in extreme cases. Other side effects include over-sedation, confusion, dizziness, fainting, slowed heart rate and breathing, and impaired attention and tracking abilities.
Due to these risks, it is recommended that you wait until your body has completely cleared itself of alcohol before taking a sleep aid. The half-life of alcohol is four to five hours, and it can take up to five half-lives (20-25 hours) for your body to fully rid itself of alcohol.
If you or someone you know is struggling with addiction to alcohol and sleep aids, professional treatment can help. Treatment for polysubstance addiction is available on an inpatient and outpatient basis. Inpatient treatment takes place in a residential facility, where patients receive 24/7 care for 30 to 90 days, limiting their access to the outside world to minimize the chance of relapse. Outpatient treatment can occur in hospitals, counselors' offices, community mental health clinics, or shared spaces within inpatient facilities.
In addition to these treatments, research has identified the brain's orexin system as a potential target for reducing cravings in people with addictions. Orexin regulates sleep/wake states, reward systems, and mood. Drugs of abuse increase orexin production, and blocking this system has been shown to reverse addiction in animal studies. One of the three orexin-blocking sleep aids approved for insomnia treatment has been found to reduce opioid cravings in humans, providing hope for its potential use in treating other addictions.
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Alcohol and melatonin
While melatonin is generally considered a safe sleep aid, there are some potential risks associated with its use, especially when taken with other substances like alcohol.
Melatonin is a hormone that helps regulate sleep cycles, and it is available as a nutritional supplement. Alcohol, on the other hand, is a central nervous system depressant that can act as a sedative and make you feel sleepy. However, consuming alcohol can also reduce the amount of melatonin your body produces, interrupting your natural sleep cycle and causing sleep problems.
Combining melatonin and alcohol can lead to several negative side effects. Both substances can increase drowsiness and impair thinking, making it difficult to focus on tasks, driving, or even walking. Additionally, mixing the two may worsen breathing during sleep, especially for those with sleep apnea. In rare cases, individuals may experience more severe reactions, including rapid heartbeat, dizziness, confusion, and increased anxiety. Furthermore, the combination of melatonin and alcohol may affect the liver's function, increasing the risk of liver damage in rare cases.
To minimize risks, it is recommended to avoid taking melatonin with alcohol. If you have consumed alcohol, it is best to wait at least 24 hours or until the alcohol is completely out of your system before taking melatonin again. This ensures that the effects of alcohol no longer interact with the melatonin supplement. It is also important to consult a healthcare professional if you have chronic sleep issues or concerns about your liver function.
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CNS depressants
When it comes to mixing alcohol and sleep aids, it is important to understand the potential risks and side effects. Firstly, alcohol increases the sedation and side effects associated with all sleep aids, whether prescription or OTC. This means that taking a sleep aid after drinking alcohol can lead to excessive drowsiness, putting you at risk of falls if you need to get up during the night. It can also cause confusion and make it harder to think clearly. The combination may also result in heightened effects of both substances, leading to dangerous and potentially deadly consequences.
Additionally, mixing alcohol with certain sleep aids can have specific adverse effects. For example, consuming alcohol with melatonin supplements may worsen breathing during sleep, especially for those with sleep apnea. A case study reported various side effects from mixing melatonin and alcohol, including rapid heartbeat, dizziness, headache, disorientation, and hallucinations. Similarly, mixing alcohol with diphenhydramine, an antihistamine found in some OTC sleep aids, can lead to more attention impairment than expected, causing people to process information and track objects more slowly.
Valerian root, an herbal supplement used as a sleep aid, can also have increased side effects when combined with alcohol, including dizziness, drowsiness, and headache. In rare cases, this combination may increase the risk of liver damage. Overall, it is crucial to follow the warnings on prescription sleep aids to avoid mixing them with alcohol and to consult a healthcare provider or pharmacist for guidance on OTC sleep aids.
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Frequently asked questions
Both alcohol and sleeping pills have sedative effects, and mixing the two can be dangerous or even deadly. Alcohol increases the side effects and sedation associated with all sleep aids, whether over-the-counter or prescription. Mixing alcohol with sleep aids can cause excessive drowsiness, confusion, dizziness, and difficulty concentrating. It can also worsen breathing during sleep and make it difficult to wake up.
Common over-the-counter sleep aids that should not be mixed with alcohol include melatonin, doxylamine (Unisom), and diphenhydramine (Benadryl, Aleve PM, Tylenol PM, Sominex). Valerian root, an herbal supplement that promotes sleep and relieves anxiety, should also be avoided with alcohol as it may increase side effects such as dizziness and drowsiness.
The half-life of alcohol is four to five hours, and it can take up to five half-lives (20-25 hours) to clear all the alcohol from your system. It is recommended to wait until your body has completely rid itself of alcohol before taking a sleep aid.











































