
Sleeping pills are medications that can help people fall asleep or stay asleep. While they can be beneficial for short-term relief from sleeplessness, they are not recommended for long-term use due to potential side effects and the risk of dependence. Research has also found a link between sleeping pills and an increased risk of cardiovascular events in heart failure patients. Specifically, a study presented at the Heart Failure Congress in 2014 suggested that sleeping pills increased the risk of cardiovascular events in this patient group by eight times. However, the researchers emphasized that larger, prospective studies are needed to confirm these findings before providing definitive recommendations. It is always advisable to consult with a healthcare professional before taking any medication, including sleeping pills, to ensure safe and appropriate use.
| Characteristics | Values |
|---|---|
| Risk of Cardiovascular Events in Heart Failure Patients | Increased by 8-fold |
| Risk of Cardiovascular Events in HFpEF Patients | Increased by 8 times |
| Benzodiazepine Hypnotics | May have cardiodepressant and respiratory depressant actions |
| Side Effects | Dependence, memory issues, balance problems, digestive problems, constipation, diarrhea, muscle weakness, confusion, etc. |
| Safety | Not recommended for children and people 65 or older |
| Long-term Use | Not recommended |
| Alternative Solutions | Self-guided digital behavioral therapy, melatonin, valerian |
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What You'll Learn

Sleeping pills and the risk of heart failure
Sleeping pills are medications that can help treat sleep problems in the short term. However, they are associated with various side effects and risks, particularly when used long-term. While there is no proven causal link between sleeping pills and heart attacks, certain studies suggest that sleeping pills may increase the risk of cardiovascular events in individuals with heart failure.
A 2014 study presented at the Heart Failure Congress in Athens, Greece, found that sleeping pills increased the risk of cardiovascular events in heart failure patients by eightfold. Specifically, the study focused on patients with heart failure with preserved ejection fraction (HFpEF) and those with heart failure with reduced ejection fraction (HFrEF). Among the HFpEF patients, those prescribed sleeping pills, particularly benzodiazepine hypnotics, had an eight times greater risk of rehospitalization for heart failure or cardiovascular-related death compared to those not prescribed sleeping pills.
Benzodiazepine hypnotics, including medications like Ativan, Librium, Valium, and Xanax, are known to have cardiodepressant and respiratory depressant actions. These effects can exacerbate sleep disordered breathing and lead to a worse prognosis for individuals with heart failure. It is important to note that the study's investigators emphasized the need for confirmation through larger, prospective studies before definitive conclusions can be made regarding the discontinuation of sleeping pills in heart failure patients.
Additionally, a meta-analysis of observational studies published in PMC suggested an association between the use of hypnotics and a decreased risk of heart disease or mortality. However, this analysis found that while zolpidem was associated with a reduced risk, benzodiazepines were linked to an increased risk of heart disease or mortality. This highlights the complexity of understanding the relationship between sleeping pills and heart health, as different types of hypnotics may have varying effects.
While the direct impact of sleeping pills on heart failure requires further research, it is clear that sleeping pills should be used with caution. Sleeping pills can cause side effects such as daytime drowsiness, dizziness, balance problems, memory issues, and digestive problems. They can also lead to dependence and rebound insomnia if used long-term. It is always recommended to consult with a healthcare provider before taking sleeping pills, especially for individuals with existing health conditions or those over 65 years old.
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Benzodiazepine hypnotics and heart failure patients
Sleeping pills can have adverse effects on heart health, especially for patients with heart failure. Benzodiazepines, a common type of hypnotic sleeping pill, have been associated with a higher risk of hospitalisation for heart failure and cardiac death. This is particularly true for patients with heart failure with preserved ejection fraction (HFpEF).
Benzodiazepine hypnotics are one of the most commonly prescribed types of sleeping pills for patients with insomnia. They target benzodiazepine sites of γ-aminobutyric acid (GABA) type A (GABAA) receptors. They allosterically increase the GABAA receptors' affinity for GABA, an inhibitory neurotransmitter, and express inhibitory effects in the central nervous system. However, they also carry risks for tolerance, dependence, and cognitive impairment.
A study published in the Journal of the American Heart Association found that among patients with heart failure and insomnia, those receiving benzodiazepines were at a higher risk of rehospitalisation for heart failure than those receiving non-benzodiazepine Z-drugs (zolpidem, zopiclone, and/or eszopiclone). The benzodiazepine group also demonstrated lower levels of haemoglobin and sodium, which are important for maintaining cardiovascular health.
Another study examined 124,445 patients from the UK Biobank and found that benzodiazepine use was significantly associated with an increased risk of cardiovascular disease, heart failure, and mortality over a median follow-up period of 14.3 years. This suggests a clear cardiovascular risk associated with these drugs.
While benzodiazepine hypnotics can improve sleep fragmentation and total nocturnal sleep time in patients with cardiac failure, they have not shown a significant effect on central hypopneas or apneas. Additionally, there are concerns about the respiratory depressant actions of benzodiazepines, which could exacerbate sleep-disordered breathing and lead to a worse prognosis for heart failure patients.
Due to the potential cardiovascular risks associated with benzodiazepine hypnotics, medical professionals should carefully discuss the benefits and harms of these medications with patients before prescribing them for insomnia. It is recommended that patients with heart failure explore other treatments for insomnia, such as cognitive behavioural therapy, before resorting to sleeping pills.
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Sleeping pills: side effects and safety concerns
Sleeping pills are medications that can help treat sleep problems in the short term. However, they can have side effects and safety concerns, especially when used long-term. It is best to consult a healthcare professional before taking any sleeping medication to ensure safe usage and avoid potential adverse effects.
Side Effects
Sleeping pills can cause various side effects, including:
- Constipation or diarrhoea
- Muscle weakness
- Digestive issues (e.g., gas, heartburn, nausea)
- Worsening of snoring and sleep apnea
- Drowsiness, muddled thinking, dizziness, and balance problems the day after taking the medication
- Dependence and rebound insomnia with prolonged use
- Memory issues and confusion, especially in older adults
- Headaches, amnesia, and tremors
Safety Concerns
Sleeping pills are not suitable for everyone, and certain groups of people should exercise caution or avoid them altogether. Here are some key safety concerns:
- Heart patients: Research suggests that sleeping pills increase the risk of cardiovascular events in heart failure patients, particularly those with heart failure with preserved ejection fraction (HFpEF). This group of patients may be at an eight times greater risk of rehospitalisation or cardiovascular-related death if prescribed sleeping pills.
- Older adults: People aged 65 and above are generally advised to try non-drug treatments first due to increased risks associated with sleeping pills. These medications can stay in their bodies longer, causing side effects like confusion, memory issues, and balance problems, which may increase the risk of falls and fractures.
- Children: Sleeping pills are not recommended for children under 16 as they have only been tested on adults, and safe dosages for younger individuals are unknown.
- Dependence and withdrawal: Prolonged use of sleeping pills can lead to physical dependence, and stopping the medication may result in rebound insomnia, where insomnia returns worse than before.
- Interactions with other medications: Sleeping pills may interact with other medications and cause serious side effects. It is essential to consult a healthcare professional before taking sleeping pills to ensure they do not interfere with any other prescriptions.
- Overdose risk: Some sleeping pills, particularly barbiturates, can be fatal in high doses.
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Sleeping pill alternatives
A study from 2014 found that sleeping pills increase the risk of cardiovascular events in heart failure patients. The researchers concluded that their results needed confirmation in larger studies before heart failure patients could be advised to stop taking sleeping pills. However, they also stated that patients who use sleeping pills, particularly those with sleep disordered breathing, should be carefully monitored.
If you are experiencing sleep issues, it is recommended to try other methods to improve your sleep before resorting to sleeping pills. This is because the long-term risks of sleeping pills often outweigh the benefits. Here are some alternatives to sleeping pills that you can try:
- Good sleep habits: This includes practices such as maintaining a consistent sleep schedule, creating a relaxing bedtime routine, and ensuring your bedroom is comfortable and conducive to sleep.
- Over-the-counter remedies: There are various over-the-counter sleep aids available, such as Benadryl Allergy®, Advil PM®, Tylenol PM®, Nytol, Sominex, and Unisom. However, it is important to consult your doctor before taking any of these medications to ensure they are safe for you.
- Melatonin supplements: Melatonin is a hormone that helps regulate the sleep-wake cycle. Taking melatonin supplements can help promote sleep, especially if your insomnia is caused by jet lag or shift work.
- Valerian: Some people use valerian supplements to help manage their insomnia, but the effectiveness of this supplement is still under debate.
- Cognitive behavioral therapy (CBT): This type of therapy can help you address any underlying psychological or behavioral factors that may be contributing to your sleep issues.
- Self-guided digital behavioral therapy: This is a type of therapy that you can access online or through mobile applications. It can provide guidance and techniques to improve your sleep without the need for medication.
- Keeping a sleep diary: Your healthcare provider may recommend tracking your sleep patterns by recording the times and quality of your sleep. This can help identify any underlying issues or patterns contributing to your sleep difficulties.
Remember, it is important to consult your healthcare provider before starting any new sleep aid or supplement to ensure it is safe and appropriate for you. They can guide you in finding the most suitable approach to improve your sleep quality.
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Sleeping pills and the risk of death
Sleeping pills can have side effects and are not recommended for long-term use. They can be habit-forming, and overuse can lead to physical dependence. It's important to use them with caution and only as directed. Sleeping pills can cause a "'hangover" effect the next day, with drowsiness, dizziness, and balance problems. They can also cause digestive issues, muscle weakness, and worsen snoring and sleep apnea.
While there is no proven direct link between sleeping pills and an increased risk of death, some studies suggest that they may be associated with a higher risk of cardiovascular events and hospitalization in heart failure patients. In particular, Benzodiazepine hypnotics, a common type of sleeping pill, may have cardiodepressant and respiratory depressant actions, which could lead to a worse prognosis for those with heart failure.
A meta-analysis of observational studies found that the use of hypnotics was associated with a decreased risk of mortality from heart disease, especially in Asia. However, benzodiazepines, a type of hypnotic, were linked to an increased risk of mortality from heart disease. It's important to note that this analysis included both sleeping pills and non-sleeping pill hypnotics, so the results may not be directly attributable to sleeping pills themselves.
Overall, while sleeping pills can be helpful for short-term relief from sleeplessness, they should be used cautiously and under medical supervision. They are not recommended for children or older adults, as the risks may outweigh the benefits for these populations. It is always best to consult a healthcare provider before taking any sleeping medication to ensure safe use and explore alternative treatments, such as cognitive behavioral therapy (CBT) or self-guided digital behavioral therapy.
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Frequently asked questions
Research has shown that sleeping pills can increase the risk of cardiovascular events in heart failure patients. However, these findings are not conclusive, and more research is needed. If you have a heart condition or are concerned about the potential side effects of sleeping pills, consult your doctor.
Yes, there are several alternatives to sleeping pills, including self-guided digital behavioural therapy, melatonin, valerian, and cognitive behavioural therapy (CBT).
Sleeping pills can cause daytime drowsiness, dizziness, balance problems, digestive issues, memory problems, and confusion. They can also be habit-forming, and it is recommended that they are used for short-term relief only.
No, sleeping pills are not suitable for everyone. They are not recommended for children under 16, and older adults are advised to explore non-drug treatments first due to the increased risk of side effects. If you are taking other medications, speak to your doctor before taking sleeping pills.

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