
Antihistamines are commonly known to cause drowsiness, leading many people to consider taking them as a sleep aid. While over-the-counter antihistamines like diphenhydramine and doxylamine succinate are easily accessible and may help with occasional sleeplessness, they are not recommended for long-term use due to potential side effects and limited effectiveness in improving sleep quality. Experts generally advise against the use of antihistamines as sleeping pills, recommending alternatives such as cognitive behavioral therapy (CBT), melatonin, and good sleep hygiene practices. Consulting a healthcare professional is essential to address chronic insomnia and determine the most suitable treatment options.
| Characteristics | Values |
|---|---|
| Effectiveness as a sleep aid | Many antihistamines cause drowsiness and are effective in aiding sleep. |
| Safety | Long-term use may lead to harmful side effects, especially in older adults. Anticholinergic antihistamines have been linked to an increased risk of dementia and Alzheimer's disease. |
| Alternatives | The American Academy of Sleep Medicine recommends cognitive behavioral therapy (CBT) as a first-line treatment for insomnia. Alternative sleep aids include melatonin and good sleep hygiene. |
| Medical advice | Consult a physician or sleep specialist to address long-term insomnia, which could result from medical issues such as sleep apnea, depression, or circadian rhythm disorders. |
| Examples of antihistamines used for sleep | Diphenhydramine, doxylamine succinate, and Benadryl. |
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What You'll Learn
- Antihistamines like diphenhydramine and doxylamine succinate can cause drowsiness
- They are easily available over the counter and are used to combat insomnia
- However, doctors caution against overuse due to potential side effects and low sleep quality
- The American Academy of Sleep Medicine recommends CBT as a first-line treatment for insomnia
- Alternative sleep aids include melatonin and good sleep hygiene practices

Antihistamines like diphenhydramine and doxylamine succinate can cause drowsiness
Antihistamines like diphenhydramine and doxylamine succinate are known to cause drowsiness. They are commonly used to treat allergies and are available over the counter. They are also found in over-the-counter sleep aids, though experts advise against using antihistamines as a sleep aid due to the lack of research supporting their effectiveness and the potential for harmful side effects.
Diphenhydramine is the active ingredient in Benadryl and ZzzQuil, and doxylamine succinate is found in Unisom. Both medications can be used for short-term sleep problems for up to two weeks. However, it is important to carefully read the package instructions as the dosage for allergies is different from that for sleep. Doxylamine stays in the body longer than diphenhydramine, so it may be more likely to cause next-day drowsiness.
Antihistamines, including diphenhydramine and doxylamine succinate, cross the blood-brain barrier and mimic the natural decrease in brain histamine levels that induces non-rapid eye movement sleep (NREM). This is why people may feel sleepy when taking medications containing these antihistamines. However, antihistamines have been associated with an increased risk of dementia and Alzheimer's disease if taken long-term. They can also cause side effects such as an altered mental state, urinary retention, and dry mouth, and may lead to sleepwalking and other parasomnias.
Instead of relying on antihistamines for sleep, it is recommended to practice good sleep hygiene and cognitive behavioural therapy (CBT). This includes maintaining a consistent sleep schedule, avoiding caffeine and alcohol in the evenings, minimising the use of electronic devices before bed, and keeping the bedroom cool, dark, and quiet. If chronic insomnia is an issue, speaking with a healthcare professional is advised. They may prescribe alternative medications or recommend lifestyle changes to improve sleep quality.
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They are easily available over the counter and are used to combat insomnia
While antihistamines are easily available over the counter, they are not recommended for use as sleeping pills. Antihistamines such as diphenhydramine and doxylamine succinate can indeed cause drowsiness, but there is little research to back up their effectiveness as sleep aids. Long-term use may also lead to harmful side effects, especially in older adults. These side effects include an altered mental state, urinary retention, dry mouth, and sleepwalking. Anticholinergic antihistamines have also been linked to an increased risk of dementia and Alzheimer's disease.
However, people sometimes use antihistamines to combat insomnia. Diphenhydramine, for example, is an antihistamine that can be found in common over-the-counter medications such as Advil PM, Excedrin PM, and Motrin PM. Because it affects the body's natural sleep-wake cycle, it can make it easier to fall asleep. Benadryl, which contains diphenhydramine, is also easily available over the counter and is often used as a sleep aid.
Experts caution against overusing antihistamines for insomnia or other sleep issues, especially in older adults. The American Academy of Sleep Medicine recommends cognitive behavioral therapy (CBT) as a first-line treatment for insomnia. CBT focuses on sleep hygiene and strengthening the bed-sleep connection. It helps adjust the circadian rhythm and reduces anxiety about insomnia. Good sleep hygiene practices include going to bed and getting up at the same time every day, avoiding alcohol, caffeine, and large meals in the evening, and refraining from using electronic devices at least half an hour before bed.
If you are experiencing chronic insomnia, it is important to consult a healthcare professional. They can help address the underlying causes of your insomnia and may prescribe medications that can help.
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However, doctors caution against overuse due to potential side effects and low sleep quality
Antihistamines like diphenhydramine and doxylamine succinate can be effective in helping people fall asleep due to their drowsy side effects. However, doctors advise against their overuse as a sleep aid because of the potential side effects and low sleep quality associated with them. Firstly, while antihistamines can make you fall asleep faster, they do not necessarily improve overall sleep quality.
Secondly, the side effects of antihistamines include an altered mental state, urinary retention, dry mouth, and sleepwalking. While these side effects are generally mild and well-tolerated in younger patients, they can pose a risk, especially for older adults. Anticholinergic antihistamines, such as diphenhydramine, have been linked to an increased risk of dementia and Alzheimer's disease with long-term use.
Thirdly, the sleep-wake cycle is regulated by chemicals naturally produced by the body, including histamine, which helps keep people awake during the day. By blocking histamine, antihistamines induce drowsiness, but they can also disrupt the body's natural sleep-wake cycle, leading to issues like non-rapid eye movement sleep (NREM) and potentially affecting sleep quality.
Finally, rather than relying on antihistamines or other sleep aids, doctors recommend addressing the underlying causes of insomnia. This may involve cognitive-behavioral therapy (CBT) to improve sleep hygiene and strengthen the bed-sleep connection, adjusting circadian rhythms, and reducing anxiety about insomnia. If chronic insomnia is an issue, consulting a healthcare professional is advised to determine the best course of treatment, which may include prescription medications.
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The American Academy of Sleep Medicine recommends CBT as a first-line treatment for insomnia
Antihistamines are not recommended for long-term use as a sleep aid due to potential side effects, including altered mental state, urinary retention, and dry mouth, and an increased risk of dementia and Alzheimer's disease. While antihistamines may help you fall asleep, they do not improve overall sleep quality. Instead, alternative sleep aids like melatonin, good sleep hygiene, and cognitive behavioural therapy are recommended.
Cognitive behavioural therapy for insomnia (CBT-I) is a multi-component, evidence-based treatment for insomnia that targets difficulties with falling asleep and staying asleep. It is a short, structured approach that focuses on restructuring the thoughts, feelings, and behaviours contributing to insomnia. The primary goal of CBT-I is to address the perpetuating factors that contribute to the development of chronic insomnia. Techniques used in CBT-I include stimulus control, sleep restriction, and relaxation training.
CBT-I is typically delivered over six to eight sessions, with each session lasting 60 to 90 minutes. During the initial session, the therapist collects clinical information, including the patient's sleep concerns, sleep history, and social and medical history. If CBT-I is deemed appropriate, the therapist provides an overview of insomnia, CBT-I, and the treatment format. Following this first session, baseline sleep data is collected for one to two weeks using a daily sleep diary.
CBT-I has been shown to be effective in treating insomnia in children, adolescents, and adults. It produces results comparable to sleep medication, without the side effects and risk of relapse associated with sleep medication. CBT-I helps individuals learn how to support and promote their body's natural sleep mechanism, resulting in long-term improvements in sleep. As such, the American Academy of Sleep Medicine recommends CBT-I as a first-line treatment for insomnia.
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Alternative sleep aids include melatonin and good sleep hygiene practices
While antihistamines can cause drowsiness, they are not recommended as sleep aids. This is because there is little research supporting their effectiveness as sleep aids, and long-term use may lead to harmful side effects. Instead, alternative sleep aids, such as melatonin and good sleep hygiene practices, are recommended.
Melatonin is a natural hormone produced by the brain to regulate sleep. It is produced in response to darkness and helps set your body's internal clock. When the body does not produce enough melatonin, sleep can be disrupted, and individuals may have trouble sleeping. Melatonin supplements are available over the counter and are fast-acting, generally taken 30 minutes before bedtime. However, it is important to note that melatonin is not a one-size-fits-all solution, and dosage instructions should always be followed, starting with the lowest recommended dose.
Good sleep hygiene practices are another essential aspect of improving sleep quality. Sleep hygiene refers to healthy sleep habits and routines that help promote better sleep. This includes maintaining a consistent sleep schedule, even on weekends, to reinforce your body's sleep cycle. Creating a relaxing bedtime routine, such as reading or listening to calming music, can also help you unwind and prepare for sleep. Reducing exposure to blue light and electronic devices before bed is beneficial, as is keeping your bedroom dark, cool, and quiet. Additionally, avoiding stimulants like caffeine and nicotine, and reducing alcohol consumption in the evenings can improve sleep quality. Maintaining a comfortable sleep environment, limiting disruptions, and ensuring a comfortable mattress and pillows are also part of good sleep hygiene practices.
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Frequently asked questions
Antihistamines can cause drowsiness and are easily available over the counter, so they are sometimes used to combat insomnia. However, doctors caution against overusing antihistamines for sleep, as there is little research to back up their effectiveness as a sleep aid, and they may have harmful side effects.
Side effects of using antihistamines as sleeping pills include altered mental state, urinary retention, dry mouth, sleepwalking, and other parasomnias. Antihistamines may also lead to cognitive impairment that persists even after you stop taking them, and increase the risk for dementia and Alzheimer's disease if taken long-term.
The American Academy of Sleep Medicine recommends cognitive behavioural therapy (CBT) as a first-line treatment for insomnia. CBT can help adjust your circadian rhythm and reduce anxiety about insomnia. You can also try alternative sleep aids like melatonin and improving your sleep hygiene.
Improving your sleep hygiene involves making lifestyle changes such as going to bed and getting up at the same time every day, avoiding alcohol, caffeine, and large meals in the evening, and refraining from using electronic devices at least half an hour before bed.







































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