
Rizatriptan (Maxalt) is a medication used to treat migraines in people aged six and up. It is available as a tablet and an orally disintegrating tablet (ODT) that is placed on the tongue. Common side effects include dizziness, headache, and sleepiness. Maxalt may interact with certain medications, including antidepressants, other migraine medications, and MAO inhibitors. It is important to consult a doctor or pharmacist before taking Maxalt to ensure safe use. This paragraph introduces the topic of potential interactions between Maxalt and sleeping pills, which will be further explored in the following paragraphs.
| Characteristics | Values |
|---|---|
| Should I take a sleeping pill with Maxalt? | Maxalt (rizatriptan) can make you feel very sleepy or dizzy. Consult a doctor before taking any medication. |
| Who should not take Maxalt? | People who have had a heart attack or stroke, or have heart disease, or a blood vessel disorder, or circulation problems, or a history of coronary artery disease, angina, or mini-stroke. Also, people who have used an MAO inhibitor in the past 14 days, or are allergic to rizatriptan. |
| What are the side effects? | Dizziness, headache, sleepiness, chest pain, heart rhythm changes, serotonin syndrome, increased blood pressure, tightness in the chest, throat, jaw, or neck, nausea, photophobia, and phonophobia. |
| What are the drug interactions? | Antidepressants, migraine headache medicines, propranolol, MAO inhibitors, and other similar migraine medications. |
| How is it taken? | As a regular tablet with a full glass of water, or as an orally disintegrating tablet placed on the tongue. |
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What You'll Learn
- Maxalt's side effects include sleepiness, so don't drive or do anything requiring attention
- Safety precautions to be aware of before taking Maxalt, including allergies, heart problems, and blood vessel issues
- Don't take Maxalt with MAO inhibitors like isocarboxazid or phenelzine within 14 days
- Maxalt may interact with antidepressants like citalopram or fluoxetine
- Combining alcohol with Maxalt may increase the risk of dizziness and drowsiness

Maxalt's side effects include sleepiness, so don't drive or do anything requiring attention
Maxalt (rizatriptan) is a medication used to treat migraines in people aged six and older. It is available as a tablet and an orally disintegrating tablet (ODT) that is placed on the tongue. Maxalt should not be taken to prevent migraines or reduce the number of attacks. It is only effective in treating a migraine that has already begun.
Maxalt has several side effects, and sleepiness is one of the most common. About 4% to 8% of people taking Maxalt reported drowsiness or fatigue as a side effect in clinical studies. Other common side effects include dizziness, headache, and chest pain. The risk of chest pain is higher in people with heart disease or at risk of developing it.
Due to the side effects of sleepiness and dizziness, it is advised that you do not drive or perform any activity that requires your attention after taking Maxalt. It is important to understand how the medication affects you before engaging in activities that require concentration.
In addition to the common side effects mentioned above, Maxalt may also cause heart rhythm problems, increased blood pressure, and serotonin syndrome when taken alone or with other medicines that affect serotonin. It is important to consult your doctor or pharmacist before taking Maxalt to ensure it is safe for you, especially if you have a history of heart problems, high blood pressure, or are taking other medications.
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Safety precautions to be aware of before taking Maxalt, including allergies, heart problems, and blood vessel issues
Maxalt is a medicine used to treat migraine headaches. It should only be taken as prescribed by a doctor and only after a clear diagnosis of migraine has been established. It is important to follow all directions on the prescription label.
There are several safety precautions to be aware of before taking Maxalt. Firstly, it should not be taken if you are allergic to rizatriptan or any other 5-hydroxytryptamine agonists (triptans). Severe allergic reactions, while rare, can occur and include symptoms such as hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. If you experience any of these symptoms, seek emergency medical help and stop taking Maxalt immediately.
Secondly, Maxalt should not be taken if you have certain heart problems or a history of heart attack or stroke, including "mini-stroke". It can cause chest pain, which may be a symptom of a heart attack, and may increase the risk of heart attack or stroke. If you have risk factors for heart disease, such as high blood pressure, high cholesterol, smoking, obesity, diabetes, or a family history of coronary artery disease, it is important to inform your doctor before taking Maxalt.
Thirdly, Maxalt should not be taken if you have a blood vessel disorder or circulation problems that cause a lack of blood supply within the body. This is because Maxalt narrows the blood vessels around the brain to relieve migraine pain, but this mechanism may also affect the blood vessels that supply the heart and brain, potentially leading to chest pain, heart attacks, heart rhythm problems, stroke, or other heart or blood vessel problems.
Additionally, Maxalt should not be taken within 24 hours before or after using certain migraine headache medicines, MAO inhibitors, or ergot-containing medications. It should also not be used during pregnancy unless the benefits outweigh the risks, and it is not recommended for use while breastfeeding as it is unknown if rizatriptan passes into breast milk. Furthermore, it should not be used to treat headaches other than migraines, such as tension headaches or headaches that cause loss of movement on one side of the body. Overuse of Maxalt may also lead to medication overuse headaches or "rebound headaches".
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Don't take Maxalt with MAO inhibitors like isocarboxazid or phenelzine within 14 days
MAO inhibitors, or monoamine oxidase inhibitors, are a class of antidepressants. They are used in modern psychiatric practice to treat intractable depression, particularly in treatment-resistant cases. Classic MAOIs include phenelzine, tranylcypromine, and isocarboxazid. These drugs can be highly effective in treating depression, but they are not frequently prescribed due to concerns about their risk profile.
Isocarboxazid, also known by the brand name Marplan, is a monoamine oxidase inhibitor. It is used to treat depressed patients, particularly those with treatment-resistant depression. Isocarboxazid has been the subject of various clinical studies examining its efficacy and safety.
Phenelzine is also a monoamine oxidase inhibitor. It is a hydrazine derivative and an inhibitor of primary-amine oxidases, or semicarbazide-sensitive amine oxidases. Phenelzine is one of the MAOIs that carries a risk of hypoglycaemia, particularly when used in combination with other medications.
Given that Maxalt is a medication used to treat migraines and severe headaches, it is important to be cautious when combining it with other drugs. MAO inhibitors, including isocarboxazid and phenelzine, can interact with other medications and lead to adverse effects. Therefore, it is recommended to wait at least 14 days after taking MAO inhibitors before taking Maxalt. This waiting period helps to minimise the risk of potential drug interactions and ensures a safer approach to medication use.
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Maxalt may interact with antidepressants like citalopram or fluoxetine
Maxalt (rizatriptan) is a prescription medication used to treat migraines in adults. It belongs to a class of drugs known as triptans, which work by constricting blood vessels in the brain, thereby relieving migraine pain. While Maxalt is effective in treating migraines, it is important to be aware of potential interactions with other substances, including antidepressants.
Maxalt may interact with certain antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). SSRIs such as citalopram (Celexa) and fluoxetine (Prozac) are commonly prescribed to treat depression and anxiety disorders. When taken together with Maxalt, there is a risk of a rare but serious condition called serotonin syndrome. Serotonin syndrome occurs when the body has too much serotonin, a neurotransmitter that regulates mood, sleep, and pain. Symptoms of serotonin syndrome include rapid heart rate, sudden changes in blood pressure, increased body temperature, restlessness, hallucinations, loss of coordination, overactive reflexes, nausea, vomiting, and diarrhea. As such, it is crucial to inform your doctor if you are taking any antidepressants before starting Maxalt.
Additionally, MAO inhibitors, a class of antidepressants that includes isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate), should not be taken with Maxalt. MAO inhibitors work by blocking the enzyme monoamine oxidase, which is responsible for breaking down triptans like Maxalt. Combining an MAO inhibitor with Maxalt can lead to dangerous drug interactions and adverse effects. Therefore, it is recommended to wait at least 14 days after discontinuing an MAO inhibitor before starting Maxalt.
Furthermore, it is important to note that Maxalt should not be taken within 24 hours of using other migraine medications, including ergotamine-containing drugs like dihydroergotamine (Migranal) and methysergide, as well as other triptan medications like sumatriptan (Imitrex). Combining Maxalt with these drugs can increase the risk of excessive blood vessel narrowing, leading to blocked blood flow and potential complications.
In conclusion, while Maxalt is a valuable treatment option for migraines, it is crucial to exercise caution and consult a healthcare professional before taking it concurrently with antidepressants like citalopram or fluoxetine. The potential risk of serotonin syndrome and drug interactions underscores the importance of disclosing all medications to your doctor to ensure safe and effective treatment.
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Combining alcohol with Maxalt may increase the risk of dizziness and drowsiness
Maxalt (rizatriptan) is a medication used to treat migraines and should be taken exactly as prescribed by a doctor. It is important to note that Maxalt is not a preventive measure and will only treat a migraine that has already begun.
Before taking Maxalt, it is crucial to discuss your prescription and over-the-counter medications, vitamins, supplements, and herbal products with your doctor and pharmacist. This includes disclosing your alcohol consumption habits and any use of cannabis or cannabis products.
It is worth noting that Maxalt is not typically prescribed in combination with certain other migraine drugs or antidepressants, as it may cause problems with blood vessels and circulation, increasing the risk of serious side effects. Additionally, Maxalt should not be taken if you have specific medical conditions, such as cardiovascular issues, ischemic bowel disease, or certain types of migraines.
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Frequently asked questions
It is not advisable to take a sleeping pill with Maxalt (rizatriptan) as it can cause drowsiness or sleepiness in 4% to 8% of people. However, there are no known interactions between rizatriptan and foods or drinks. Consult your doctor or pharmacist before taking any medication in combination with Maxalt.
Maxalt is used to treat migraines with or without aura in people aged six and above. Common side effects include dizziness, headache, sleepiness, chest pain, and an increased risk of heart attack or stroke. It can also cause serotonin syndrome, which is a life-threatening condition with excess serotonin in the body.
You must wait for at least two hours after taking a Maxalt tablet before taking another one. The recommended starting dose for adults is 5 mg or 10 mg. Do not take more than 30 mg of rizatriptan in 24 hours.
No, you should not take Maxalt with other migraine headache medicines or ergot-containing medications. Consult your pharmacist to ensure you are not taking Maxalt with any medicines it may interact with.










































