
Desyrel (trazodone) is a prescription medication that has been used to treat depression and anxiety for many years. It is also sometimes prescribed as a sleep aid. While trazodone is not approved by the FDA for treating sleep disorders, it is often prescribed off-label for this purpose due to its sedative effects. Trazodone is well-tolerated for the short-term treatment of insomnia in adults, but there is limited research on its long-term effectiveness and safety. It is not recommended for use in children, as it has been linked to an increased risk of suicidal thoughts and behaviours in young people.
| Characteristics | Values |
|---|---|
| Common Name | Trazodone |
| Brand Names | Desyrel, Desyrel Dividose, Molipaxin, Oleptro, Trazorel, Trittico |
| Type of Drug | Antidepressant |
| Approved Uses | Treatment of depression and anxiety |
| Off-Label Uses | Treatment of sleep disorders such as insomnia |
| Effectiveness | May decrease nightly awakenings and improve subjective sleep quality |
| Side Effects | Dizziness, drowsiness, slowed movements, impaired reactions, increased fall risk, stomach upset, anxiety, irritability, restlessness, trouble sleeping, suicidal thoughts, and more |
| Interactions | Opioids, sleeping pills, muscle relaxers, anti-anxiety medications, antidepressants, mood stabilizers, MAO inhibitors, St. John's wort, alcohol, and more |
| Addiction Potential | Not addictive |
| Availability | Prescription medication |
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What You'll Learn
- Desyrel (trazodone) is an antidepressant that can be prescribed as a sleep aid
- It is not addictive and may be less expensive than other insomnia drugs
- Desyrel may cause side effects such as dizziness and drowsiness
- It can be dangerous when combined with other drugs, including alcohol
- Desyrel is not approved for use by anyone under 18 years old

Desyrel (trazodone) is an antidepressant that can be prescribed as a sleep aid
Trazodone is often prescribed for sleep problems when other treatments have been ineffective or not well-tolerated. It is typically taken on an “as-needed” basis, with a low dose taken once daily at bedtime. It is important to note that trazodone interacts with many medications, including other sleep aids, anti-anxiety medications, antidepressants, and mood stabilizers. Therefore, it is crucial to consult a doctor before taking trazodone, especially if you are already taking any other prescription or over-the-counter medications.
Trazodone has been found to be well-tolerated for the short-term treatment of insomnia in adults, improving sleep quality better than a placebo. However, there is a lack of long-term safety and effectiveness data for its use as a sleep aid. Additionally, it has been associated with a higher fall risk compared to other insomnia treatments.
While trazodone can be beneficial for sleep, it is important to be aware of its potential side effects. It can cause dizziness, drowsiness, and slowed reactions, so activities that require alertness, such as driving or operating heavy machinery, should be avoided until you know how it affects you. It can also cause more serious side effects, such as a painful or prolonged erection (priapism), and may worsen certain medical conditions, such as bipolar disorder or hypomagnesemia. Therefore, it is important to discuss the benefits and risks with your doctor before taking trazodone.
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It is not addictive and may be less expensive than other insomnia drugs
Desyrel (trazodone) is a prescription medication that is approved by the FDA to treat depression and anxiety. However, it is sometimes prescribed off-label as a sleep aid for insomnia. While trazodone can be an effective sleep aid, it is important to note that it is not a replacement for good sleep hygiene, relaxation techniques, or cognitive behavioural therapy (CBT).
One of the benefits of trazodone is that it is not considered addictive by doctors. This is in contrast to other medications used to treat insomnia, such as benzodiazepines, which can be addictive. Trazodone works by regulating the neurotransmitter serotonin, which helps brain cells communicate with each other and influences sleep, thoughts, mood, appetite, and behaviour. Even at lower doses, trazodone can cause sleepiness because it blocks chemicals in the brain that interact with serotonin and other neurotransmitters, such as histamine, which keeps you awake and alert.
In addition to being non-addictive, trazodone may also be less expensive than other insomnia drugs because it is available generically. This can make it a more affordable option for people struggling with sleep disorders. However, it is important to note that trazodone may not be covered by insurance, so it is always a good idea to check with your insurance provider before starting any new medication.
While trazodone can be an effective and affordable option for treating insomnia, it is not without its risks. Some people may experience side effects such as dizziness, drowsiness, and slowed reactions. It is important to avoid driving or operating heavy machinery until you know how trazodone affects you. Additionally, trazodone can interact with other medications, including other sleep aids, anti-anxiety medications, and antidepressants. It is important to talk to your doctor about all the medications you are taking before starting trazodone.
In conclusion, Desyrel (trazodone) is a prescription medication that can be an effective and non-addictive option for treating insomnia. It may also be less expensive than other insomnia drugs. However, it is important to weigh the benefits against the risks and side effects, and to always consult with a healthcare professional before starting any new medication.
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Desyrel may cause side effects such as dizziness and drowsiness
Desyrel (trazodone) is a prescription medication that has been used to treat depression and anxiety for many years. It is also sometimes prescribed as a sleep aid, although this is considered an "off-label" use, as it is not approved by the FDA for this purpose.
The medicine may cause some people to become drowsy or less alert than usual. It is important to know how you react to this medicine before engaging in activities that require alertness, such as driving or operating heavy machinery. Alcohol and other central nervous system (CNS) depressants can increase the risk of these side effects and should be used with caution or avoided altogether.
Desyrel can also cause more serious side effects, such as a painful or prolonged erection of the penis, which requires emergency medical attention. Other rare but serious side effects include mood or behavior changes, anxiety, panic attacks, and trouble sleeping. It is important to report any new or worsening symptoms to your doctor.
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It can be dangerous when combined with other drugs, including alcohol
Desyrel (trazodone) is a prescription medication that is approved by the FDA as an antidepressant in adults. However, doctors sometimes prescribe it as a sleep aid, particularly for insomnia. While trazodone is not addictive, it can be dangerous when combined with other drugs, including alcohol.
Trazodone can cause drowsiness and impaired reactions, and these effects may be worsened when combined with alcohol. Alcohol consumption while taking trazodone can lead to dangerous side effects or even death. An overdose of Desyrel combined with alcohol can be fatal. Overdose symptoms may include extreme drowsiness, vomiting, painful penis erection, a fast or pounding heartbeat, seizures, or slowed or stopped breathing.
Trazodone may also interact with other medications that have similar effects, such as opioid medications, sleeping pills, muscle relaxers, antihistamines, or medications for allergies, colds, seizures, or pain. These combinations can further increase the risk of adverse effects, including falls, which are more common in patients treated with trazodone compared to those taking other sleep medications.
Additionally, trazodone should not be used with certain types of drugs, such as MAO inhibitors. Combining trazodone with MAO inhibitors can lead to a dangerous drug interaction. It is important to consult a doctor or pharmacist before taking trazodone with any other medications or substances to ensure safety and avoid potentially harmful interactions.
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Desyrel is not approved for use by anyone under 18 years old
Desyrel (trazodone) is a prescription medication that has been used to treat depression and anxiety for many years. It is an antidepressant that is sometimes prescribed as a sleep aid. Desyrel may be prescribed to treat sleep disorders such as insomnia, especially when other treatments have been ineffective. It is not addictive and may be less expensive than other insomnia drugs. However, it is not approved for use by anyone under 18 years old.
Desyrel is not a sleep medicine, but it has a sedative effect that causes drowsiness. This is because it blocks histamines, which are the brain neurotransmitters that keep you awake and alert. It also helps serotonin build up in the brain, which regulates mood, sleep, hunger, and body temperature. Low serotonin levels can cause depression, anxiety, bipolar disorder, and many other mental health conditions.
Desyrel is not approved for use by anyone younger than 18 years old. This is because antidepressants such as Desyrel have been linked to an increased risk of suicidal thoughts and behaviours in children and young adults. While Desyrel may be prescribed off-label to adolescents when the benefits outweigh the risks, it is not approved for use by children.
Desyrel can have serious side effects and may interact with other medications, especially when combined with alcohol. It is important to consult a doctor about any other medications being taken and to be aware of potential side effects before taking Desyrel. It is also important to follow the dosing schedule as given by a doctor and not to take more than the recommended dosage.
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Frequently asked questions
Desyrel, also known as Trazodone, is an antidepressant that is used to treat major depressive disorder. It is also sometimes prescribed as a sleep aid due to its sedative effects.
Desyrel helps serotonin build up in the brain by blocking it from entering nearby nerve cells. This process increases serotonin levels, which influences sleep, thoughts, mood, appetite, and behavior. Desyrel also blocks histamines, which are neurotransmitters that keep you awake and alert.
Desyrel may cause side effects such as dizziness, drowsiness, and impaired reactions. It may also increase the risk of falls and interact with other medications, including opioid medications, sleeping pills, and muscle relaxants. It is important to consult a doctor before taking Desyrel and to follow the prescribed dosing schedule. Desyrel is not approved for use in children and adolescents.














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