
Naltrexone is a medication used to treat alcohol and opioid use disorders. It is not a cure for addiction but is used as part of a holistic treatment program that may include counselling, support group meetings, and other treatments. Naltrexone can cause insomnia in 3% of people who take it, as well as nervousness and anxiety. It can also cause drowsiness, fatigue, dizziness, sedation, and fainting. If you are experiencing sleep disturbances while taking naltrexone, it is important to determine the cause and address any underlying health issues. It is recommended to consult with a healthcare provider to weigh the risks and benefits of taking sleep aids alongside naltrexone, as combining it with other medications that cause drowsiness may worsen this side effect.
| Characteristics | Values |
|---|---|
| Naltrexone treatment | Used to treat opioid and alcohol use disorders |
| Naltrexone side effects | Insomnia, nervousness, anxiety, upset, increased energy, reckless behaviour, violent feelings, anger, restlessness, fear |
| Naltrexone administration | Oral, intramuscular injection |
| Naltrexone dosage | Oral: daily; Injection: once per month |
| Naltrexone prescription | Prescribed by licensed practitioners |
| Naltrexone overdose | Using opioids while on naltrexone can lead to overdose and death |
| Naltrexone and sleep | Low-dose naltrexone (LDN) may affect sleep patterns |
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What You'll Learn
- Naltrexone may cause insomnia, nervousness, and anxiety
- It is not recommended to take opioids with naltrexone
- Naltrexone may cause drowsiness, fatigue, dizziness, and fainting
- It is important to consult a healthcare provider about any sleep issues before taking naltrexone
- Low-dose naltrexone (LDN) may affect sleep patterns

Naltrexone may cause insomnia, nervousness, and anxiety
Naltrexone is a medication that treats opioid use disorder and alcohol use disorder. It is not an opioid and does not cause withdrawal symptoms. It works by blocking the euphoric effects of opioids and alcohol, reducing cravings, and helping users stay drug-free and maintain their recovery. Naltrexone is available as an oral tablet, injectable, and topical form.
Naltrexone may cause several side effects, including insomnia, nervousness, and anxiety. These side effects are typically mild and temporary, lasting a few days to weeks. However, if they persist or become bothersome, it is important to consult a doctor or pharmacist for advice.
Insomnia occurs in about 3% of people taking naltrexone. It can cause trouble sleeping, which may be a concern for those already experiencing sleep disturbances. Nervousness affects 4% of naltrexone users, and anxiety affects 2%. These side effects can be disruptive to overall well-being and daily functioning.
Other common side effects of naltrexone include digestive issues such as nausea, abdominal pain or cramps, constipation, and diarrhea. It can also cause sleepiness or drowsiness, fatigue, dizziness, and headaches. In rare cases, more serious side effects such as liver problems, depression, and allergic reactions may occur.
It is important to note that side effects can vary depending on the dosage and the condition being treated. Most patients take their naltrexone tablet in the morning, but this is not a requirement specified by the manufacturer. Consulting a healthcare provider is essential to determine the best time of day to take naltrexone to minimize unwanted side effects.
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It is not recommended to take opioids with naltrexone
Naltrexone is a medication that has been approved by the Food and Drug Administration (FDA) for treating alcohol use disorder (AUD) and opioid use disorder (OUD). It is not an opioid and does not cause withdrawal symptoms. Instead, it functions by blocking the sedative, euphoric, and rewarding effects of opioid drugs. When taken, naltrexone binds with opioid receptors in the brain, preventing them from being triggered by opioids like heroin and morphine. This means that naltrexone can reduce cravings and help patients stay drug-free and maintain their recovery.
However, it is important to note that naltrexone treatment should only be started after a patient is no longer taking opioids. This is because naltrexone can cause withdrawal symptoms in people who are still using opioids. Healthcare providers must ensure that patients have been fully withdrawn from all opioids before starting naltrexone treatment. The length of time before starting naltrexone treatment may depend on the type of opioid, the dosage, and the duration of opioid use. It is typically recommended to stop using opioids for at least 7 to 10 days before starting naltrexone.
Additionally, patients should be aware that relapsing after a period of opioid abstinence or stopping naltrexone treatment can be dangerous. Due to the body's increased sensitivity to opioids during naltrexone treatment, relapsing with the previously used opioid dosage may have life-threatening consequences, including respiratory arrest, circulatory collapse, and even death. Therefore, it is crucial not to attempt to overcome the effects of naltrexone by taking opioids.
In conclusion, while naltrexone is an effective medication for treating opioid use disorder, it is not recommended to take opioids with naltrexone. Naltrexone should only be taken after a patient has stopped using opioids, and relapsing with opioid use during or after naltrexone treatment can be extremely dangerous. Patients should always consult with their healthcare provider before starting or stopping any medication, including naltrexone, and follow their recommendations for a safe and effective treatment plan.
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Naltrexone may cause drowsiness, fatigue, dizziness, and fainting
Naltrexone is a medication used to treat opioid and alcohol use disorders. It is not an opioid and does not cause withdrawal symptoms. However, it can cause certain side effects, including drowsiness, fatigue, dizziness, and fainting.
Drowsiness, or somnolence, has been reported in 2% of patients taking naltrexone tablets for alcoholism. This side effect can also occur in combination with other medications that cause drowsiness or sedation. If you experience extreme drowsiness with slowed breathing, it could be a sign of an opioid overdose, which can be life-threatening. Therefore, it is important to inform your doctor if you are taking any other medications or supplements while on naltrexone.
Dizziness has been reported in 4% of patients taking naltrexone tablets and 13% of patients receiving the extended-release injection (Vivitrol). To reduce the risk of dizziness or fainting, it is recommended to sit up or stand slowly when changing positions. Additionally, naltrexone may affect your coordination, reaction time, or judgment, so it is advised to avoid driving or operating heavy machinery until you know how naltrexone affects you.
Fatigue can be a sign of a more serious underlying condition, such as liver problems or depression. If you experience fatigue along with symptoms like pain in the stomach area, dark-colored urine, or yellowing of the eyes or skin, seek medical attention as these could indicate liver issues. Additionally, fatigue or tiredness can be a symptom of depression, which may lead to suicidal thoughts or behaviour. Therefore, it is important to inform your doctor if you have a history of mental health disorders before starting naltrexone treatment.
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It is important to consult a healthcare provider about any sleep issues before taking naltrexone
Naltrexone is a medication used to treat opioid and alcohol use disorders. It is not an opioid and does not cause dependence or withdrawal symptoms. However, it can cause side effects such as insomnia, nervousness, and anxiety. It is important to consult a healthcare provider about any sleep issues before taking naltrexone, as they may recommend adjusting the dosage or timing of the medication. Additionally, they can advise on other sleep hygiene practices or underlying issues that may be impacting your sleep, such as metabolic syndrome, stress response, or hormonal changes.
Naltrexone works by blocking the euphoric and rewarding effects of opioids and alcohol, reducing cravings and helping individuals maintain their recovery. It is typically started after an individual has stopped taking opioids for a period of time, and the length of time may vary depending on the specific opioid, the dosage, and the duration of use. Naltrexone is available in pill form or as an extended-release intramuscular injection, and it can be prescribed by any licensed healthcare provider.
The side effects of naltrexone may include insomnia, nervousness, anxiety, increased energy, and strong emotions such as anger or restlessness. It is important to inform your healthcare provider if you experience any of these side effects, as they may suggest adjustments to the medication or provide additional support. Additionally, if you are taking other medications, such as thyroid medication, it is crucial to separate the doses by at least an hour to avoid any potential interactions.
Low-dose naltrexone (LDN) can also impact sleep patterns. If LDN changes your sleep pattern for more than five to seven days, it is recommended to take it in the morning. Taking LDN in the morning may also be preferable if you are taking other medications, such as thyroid medication, to ensure proper spacing between doses. However, it is always advisable to consult with your healthcare provider before adjusting the timing of your medication.
In summary, it is important to consult a healthcare provider about any sleep issues before taking naltrexone. They can provide guidance on managing side effects, adjusting dosages or timing, and improving sleep hygiene practices. Additionally, they can help address any underlying issues that may be impacting your sleep. Remember that the use of naltrexone is only part of your treatment, and it should be combined with other supportive measures for effective recovery.
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Low-dose naltrexone (LDN) may affect sleep patterns
Naltrexone is a medication approved by the Food and Drug Administration (FDA) for treating alcohol use disorder (AUD) and opioid use disorder (OUD). It works by blocking the euphoric effects of opioids and alcohol, reducing cravings, and helping patients stay sober. Naltrexone is typically taken orally, but there is also a long-acting intramuscular injection form called Vivitrol.
Low-dose naltrexone (LDN) is currently being studied for its potential in treating a wide range of disorders, including fibromyalgia, post-COVID syndrome, Crohn's disease, chronic pain, multiple sclerosis, and inflammatory skin disorders. LDN is thought to act as an anti-inflammatory agent in the central nervous system, and it has been shown to improve sleep, fatigue, and cognitive symptoms in patients with certain conditions.
One of the side effects of LDN is its potential impact on sleep patterns. While LDN is generally well-tolerated, some individuals have reported experiencing vivid dreams or, in rarer cases, nightmares. These vivid dreams can occur as soon as the first dose and may decrease over time. However, it is important to note that these dreams do not seem to disrupt normal sleep patterns, and individuals generally report improved sleep quality while taking LDN.
If you are considering taking LDN, it is important to consult with a healthcare provider. They can advise you on the potential benefits, risks, and interactions with any other medications you may be taking. Additionally, if you experience any sudden or strong feelings, including nervousness, anxiety, restlessness, or violent thoughts, it is crucial to inform your healthcare provider.
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Frequently asked questions
It is not advisable to take sleep aids with naltrexone without first consulting your doctor. While there are no known interactions with sleep aids, naltrexone is a powerful medication that should be closely monitored by a healthcare professional.
Melatonin is a natural sleep aid that can be taken to help with sleep disturbances caused by starting low-dose naltrexone. However, it is always recommended to consult a doctor before taking any new medications or supplements.
Yes, low-dose naltrexone (LDN) is often taken at night due to its effects on the mental state. It can cause feelings of depression, so taking it at night helps to sleep through this initial effect.
Naltrexone should not be taken with opioid medications, including morphine, codeine, hydromorphone, and oxycodone. It can cause serious side effects and withdrawal symptoms. For other medications, consult your doctor, as naltrexone may interact differently with other drugs.
Naltrexone is used to treat alcohol use disorder, but it will not prevent impairment while drinking. It is important to follow your doctor's instructions when taking naltrexone and to be cautious when consuming alcohol.






















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